Padrão de distribuição nacional das iniciativas de apoio aos arranjos produtivos locais

"Esta dissertação procura avaliar a determinação e a dinâmica da taxa de câmbio no Brasil no período pós-plano Real utilizando-se da abordagem monetária de determinação da taxa de câmbio em suas versões com preços flexíveis e com preços rígidos. A determinação da taxa de câmbio é estudada através da técnica de co-integração e a dinâmica é analisada através das funções de impulso-resposta obtidas pelas estimações de vetores auto-regressivos. A constatação empírica é de que tanto com preços flexíveis quanto com preços rígidos os sinais esperados dos coeficientes estimados dos determinantes da taxa de câmbio estão de acordo com a sugestão teórica. Porém, ao analisar-se a dinâmica da taxa de câmbio, apenas o modelo monetário com preços rígidos apresenta resultado satisfatório, respeitando a sugestão teórica."

Oxidação de acetato a CO2 em diferentes concentrações de K+ por córtex cerebral de ratos adultos normonutridos e desnutridos

47

AMAZON ACAI AND PINEAPPLE RESIDUES INDUCE THE ENZYME LACCASE IN Pleurotus ostreatus: APPLICATION TO BISPHENOL A BIOREMEDIATION

Bisphenol A (BPA), an endocrine disruptor used in different commercial polymers, is a persistent pollutant commonly found in effluents. Conventional wastewater treatment processes have low chemical removal efficiency and are expensive. This work evaluated BPA removal using laccase enzyme produced from white rot fungus Pleurotus ostreatus. For the enzymatic production, residues of acai berry and pineapple were used as laccase inducers. The use of natural inducers led to a high enzyme production (1139 and 1031 U mL−1 to acai and pineapple, respectively). Bisphenol A was removed to a concentration lower than LOD (limit of detection) after 4 h. The degradation mechanism of BPA occurred by oxidation of methyl to hydroxymethyl group in a propane portion, with breakdown of the aromatic ring. The developed technology brought to the scene a new green, viable methodology, using vegetable waste, adding value to these residues and bringing an alternative to the BPA treatment

Efeito da desnutrição pré-gestacional, gestacional e lactacional sobre parâmetros bioquímicos do cerebelo e fígado de ratos de 21 dias

47

Efeito da desnutrição protéica sobre alguns aspectos do metabolismo hepático em ratas submetidas à desnutrição protéica pré-gestacional, gestacional e lactacional

47

Efeito da monesina e da ouabaína em diferentes concentrações de K+ sobre captação de deoxiglicose e oxidação de glicose por fatias de córtex cerebral de ratos adultos

47

Identification of metabolic pathways influenced by the G-protein coupled receptors GprB and GprD in Aspergillus nidulans

Heterotrimeric G-protein-mediated signaling pathways play a pivotal role in transmembrane signaling in eukaryotes. Our main aim was to identify signaling pathways regulated by A. nidulans GprB and GprD G-protein coupled receptors (GPCRs). When these two null mutant strains were compared to the wild-type strain, the DeltagprB mutant showed an increased protein kinase A (PKA) activity while growing in glucose 1% and during starvation. In contrast, the DeltagprD has a much lower PKA activity upon starvation. Transcriptomics and (1)H NMR-based metabolomics were performed on two single null mutants grown on glucose. We noted modulation in the expression of 11 secondary metabolism gene clusters when the DeltagprB and DeltagprD mutant strains were grown in 1% glucose. Several members of the sterigmatocystin-aflatoxin gene cluster presented down-regulation in both mutant strains. The genes of the NR-PKS monodictyphenone biosynthesis cluster had overall increased mRNA accumulation in DeltagprB, while in the DeltagprD mutant strain the genes had decreased mRNA accumulation. Principal component analysis of the metabolomic data demonstrated that there was a significant metabolite shift in the DeltagprD strain. The (1)H NMR analysis revealed significant expression of essential amino acids with elevated levels in the DeltagprD strain, compared to the wild-type and DeltagprB strains. With the results, we demonstrated the differential expression of a variety of genes related mainly to secondary metabolism, sexual development, stress signaling, and amino acid metabolism. We propose that the absence of GPCRs triggered stress responses at the genetic level. The data suggested an intimate relationship among different G-protein coupled receptors, fine-tune regulation of secondary and amino acid metabolisms, and fungal development