Descripción de la flora causante de candidemia en pacientes adultos críticamente enfermos y determinación de los factores de riesgo relacionados en las unidades de cuidado intensivo del Hospital Militar Central en los años 2006 a 2011

El presente proyecto de investigación busca describir la distribución epidemiológica de las diferentes especies de Cándida spp, causantes de candidemia en los pacientes adultos ingresados a las Unidades de Cuidado Intensivo del Hospital Militar Central durante los años 2006 a 2011. Se trata de una investigación de diseño descriptivo analítico retrospectivo a realizarse mediante la revisión y recolección de datos de las historias clínicas de los pacientes con hemocultivos positivos para cándida de acuerdo con los registros de la sección de Microbiología del Laboratorio Clínico del HM

Estimation of the reference points for the different OMs in the Cod 3M MSE

This paper presents different methods to estimate the reference points (Blim, Bmsy and Fmsy) to be used in the 3M NAFO cod MSE. Reference points should be specific for each of the possible realities, what defines the different possible realities are the different OMs and, within each OM, the different iterations. The methods presented here try to estimate the reference points by iteration for the different OMs since it is assuming that the reference points will be interpreted as a characteristic of the “real” population. The results of some of the methods proposed to estimate the management reference points (limit and target) seem to be not consistent between them. The results show that in this case the proxy used as Fmsy (F30%SpR) seems quite reasonable

Standardized CPUE Indices for Greenland Halibut in NAFO Regulatory Area of Divisions 3LMNO Based on Spanish Commercial Catch Rates

A standardized CPUE series using a log-linear model for Greenland halibut in NAFO Regulatory Area of Divisions 3LMNO, based on catch and effort data from the Spanish trawl fleet since 1992 is presented. Fixed factors considered in the model were year, month, division, depth stratum and vessel and the interactions included were division*month and division*depth stratum. All of these factors and interactions are statistically significant. The total proportion of variance explained by this model is 46%. The results indicate substantial variability of CPUE over time, with several short periods of increasing and decreasing CPUE. After having reached the lowest value of the series in 2004, standardized CPUE has increased very substantially, reaching a value in 2006 very near the maximum of the entire series

Assessment of the Cod Stock in NAFO Division 3M

An assessment of the cod stock in NAFO Division 3M was conducted using a Bayesian SCAA (statistical catch-at-age) model. The STACFIS catch estimates and the Flemish Cap survey indices were used to fit the model. Blim, defined as the SSB of 2007, was estimated at 15 408 t (median). Results indicate a general increase in SSB since 2005 to the highest value in 2017, decreasing sharply since then. SSB has been above Blim since 2008. Between 2013 and 2018 recruitment was at very low levels; the 2016 and 2018 values were among the lowest of the series; as a consequence, 3-year projections indicate that total biomass will decrease during the projected years, while the SSB could increase under some scenarios in the final projected year. Depending on the projected scenario, probability of SSB being below Blim in 2023 and 2024 is high (≥12%) or very low (≤5%). An increase in recruitment occurred in 2019 and 2020, reaching the 2008 level.Versión del editor

Report of the NAFO Joint Commission-Scientific Council Working Group on Risk-Based Management Strategies (WG-RBMS) Meeting

The meeting was opened by the co-Chairs Fernando González-Costas (European Union) and Ray Walsh (Canada) at 08:30 hours (Atlantic Daylight Time in Halifax, Nova Scotia) on Tuesday, 24 August 2021. The co-Chairs welcomed the representatives from Canada, European Union, Japan, Norway, Russian Federation, United Kingdom and the United States of America. The Scientific Council (SC) Chair, SC Precautionary Approach Working Group (PA-WG) co-Chairs were also welcomed (Annex 1)

Report of the NAFO Commission Ad hoc Working Group to Reflect on the Rules Governing Bycatches, Discards and Selectivity (WG-BDS) in the NAFO Regulatory Area Meeting

The meeting was opened at 10:05 hours (Atlantic Daylight Time in Halifax, Nova Scotia) on Monday, 12 July 2021 by the Chair, Temur Tairov (Russian Federation). He welcomed representatives from Canada, Denmark (in respect of Faroe Islands and Greenland), European Union, Iceland, Japan, Norway, United Kingdom, and the United States of America. The SC Chair and the STACTIC vice Chair were also in attendance (Annex 1)

Report of the NAFO Joint Commission–Scientific Council Catch Estimation Strategy Advisory Group (CESAG) Meeting

The NAFO Joint Commission-Scientific Council Catch Estimation Strategy Advisory Group (CESAG) met via WebEx on 13 April 2021. The meeting was opened at 9:30 hours (Atlantic Daylight Time) by co-Chairs Katherine Sosebee (USA) and Temur Tairov (Russian Federation). Representatives from NAFO Contracting Parties (Canada, European Union, Japan, Ukraine) were in attendance. The Scientific Council Chair was also in attendance (Annex 1)

Elucidation of molecular kinetic schemes from macroscopic traces using system identification

Overall cellular responses to biologically-relevant stimuli are mediated by networks of simpler lower-level processes. Although information about some of these processes can now be obtained by visualizing and recording events at the molecular level, this is still possible only in especially favorable cases. Therefore the development of methods to extract the dynamics and relationships between the different lower-level (microscopic) processes from the overall (macroscopic) response remains a crucial challenge in the understanding of many aspects of physiology. Here we have devised a hybrid computational-analytical method to accomplish this task, the SYStems-based MOLecular kinetic scheme Extractor (SYSMOLE). SYSMOLE utilizes system-identification input-output analysis to obtain a transfer function between the stimulus and the overall cellular response in the Laplace-transformed domain. It then derives a Markov-chain state molecular kinetic scheme uniquely associated with the transfer function by means of a classification procedure and an analytical step that imposes general biological constraints. We first tested SYSMOLE with synthetic data and evaluated its performance in terms of its rate of convergence to the correct molecular kinetic scheme and its robustness to noise. We then examined its performance on real experimental traces by analyzing macroscopic calcium-current traces elicited by membrane depolarization. SYSMOLE derived the correct, previously known molecular kinetic scheme describing the activation and inactivation of the underlying calcium channels and correctly identified the accepted mechanism of action of nifedipine, a calcium-channel blocker clinically used in patients with cardiovascular disease. Finally, we applied SYSMOLE to study the pharmacology of a new class of glutamate antipsychotic drugs and their crosstalk mechanism through a heteromeric complex of G protein-coupled receptors. Our results indicate that our methodology can be successfully applied to accurately derive molecular kinetic schemes from experimental macroscopic traces, and we anticipate that it may be useful in the study of a wide variety of biological systems