14 research outputs found

    Direct observation of transverse and vortex metastable magnetic domains in cylindrical nanowires

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    We present experimental evidence of transverse magnetic domains, previously observed only in nanostrips, in CoNi cylindrical nanowires with designed crystal symmetry and tailored magnetic anisotropy. The transverse domains are found together with more conventional vortex domains along the same cylindrical nanowire, denoting a bistable system with similar energies. The surface and the inner magnetization distribution in both types of domains are analyzed by photoemission electron microscopy with x-ray magnetic circular dichroism contrast, and hysteresis loop in individual nanowires are measured by magneto-optical Kerr effect. These experimental data are understood and compared with complementary micromagnetic simulations

    Knowledge, attitudes and preventive practices of primary health care professionals towards alcohol use: A national, cross-sectional study

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    Introduction Primary care (PC) professionals' knowledge about alcohol use has been identified as one of the barriers PC providers face in their clinic. Both PC professionals' level of training and attitude are crucial in the clinical practice regarding alcohol use. Objective To evaluate the knowledge, attitude, and preventive practices of Spanish PC physicians and nurses towards alcohol use. Design An observational, descriptive, cross-sectional, multi-center study. Methodology Location: PC centers of the Spanish National Health System (NHS). Participants: PC physicians and nurses selected randomly from health care centers, and by sending an e-mail to semFYC and SEMERGEN members. Healthcare providers completed an online survey on knowledge, attitude, and follow-up recommendations for reducing alcohol intake. A descriptive, bivariate, and multivariate statistical analysis was conducted (p<0.05). Results Participants: 1, 760 healthcare providers completed the survey (75.6% [95% CI 73.5-77.6] family physicians; 11.4% [95% CI 9.9-12.9] medical residents; and 12.5% [95% CI 10.9-14.1] nurses), with a mean age of 44.7 (SD 11.24, range: 26-64, 95% CI: 47.2-48.2). Knowledge was higher in family physicians (p<0.001), older professionals (Spearman's r = 0.11, p<0.001), and resident trainers (p<0.001). The PC professional most likely to provide advice for reducing alcohol use was: a nurse (p<0.001), female (p = 0.010), between 46 and 55 years old (p <0.001). Conclusions PC providers' knowledge and preventive practices regarding alcohol use are scarce, hence specific training strategies to increase their knowledge and improve their attitude and skills with regard to this health problem should be considered a healthcare policy priority

    ATLAS detector and physics performance: Technical Design Report, 1

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    Whole-genome sequencing reveals host factors underlying critical COVID-19

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    Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

    Direct observation of transverse and vortex metastable magnetic domains in cylindrical nanowires

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    We present experimental evidence of transverse magnetic domains, previously observed only in nanostrips, in CoNi cylindrical nanowires with designed crystal symmetry and tailored magnetic anisotropy. The transverse domains are found together with more conventional vortex domains along the same cylindrical nanowire, denoting a bistable system with similar energies. The surface and the inner magnetization distribution in both types of domains are analyzed by photoemission electron microscopy with x-ray magnetic circular dichroism contrast, and hysteresis loop in individual nanowires are measured by magneto-optical Kerr effect. These experimental data are understood and compared with complementary micromagnetic simulations

    Adjuvant therapy in pancreatic cancer: historical and current perspectives

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    Measurement of elastic J/#psi# photoproduction at HERA

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    The reaction #gamma# p #-&gt;# J/#psi#p has been studied in ep interactions using the ZEUS detector at HERA. The cross section for elastic J/#psi# photoproduction has been measured as a function of the photon-proton centre of mass energy W in the range 40 &lt; W &lt; 140 GeV at a median photon virtuality Q&quot;2 of 5 x 10&quot;-&quot;5 GeV&quot;2. The photoproduction cross section, #sigma#_#gamma#_p_#-&gt;#_J_/_#psi#_p, is observed to rise steeply with W. A fit to the data presented in this paper to determine the parameter #delta# in the form #sigma#_#gamma#_p_#-&gt;#_J_/_#psi#_p #propor to# W&quot;#delta# yields the value #delta# = 0.92 #+-# 0.14 #+-# 0.10. The differential cross section d#sigma#/d vertical stroke t vertical stroke is presented over the range vertical stroke t vertical stroke &lt; 1.0 GeV&quot;2 where t is the square of the four-momentum exchanged at the proton vertex. d#sigma#/d vertical stroke t vertical stroke falls exponentially with a slope parameter of 4.6 #+-# 0.4&quot;+&quot;0&quot;.&quot;4_-_0_._6 GeV&quot;-&quot;2. The measured decay angular distributions are consistent with s-channel helicity conservation. (orig.)Available from FIZ Karlsruhe / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman
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