Vulnerability and access in adolescent health in view of the parents

Objetivo: analisar a percepção de pais sobre vulnerabilidades e necessidades de acesso em saúde na adolescência no município de Contagem/Minas Gerais. Método: Trata-se de estudo descritivo desenvolvido com 94 pais de adolescentes de 12 escolas públicas municipais que responderam a um questionário semiestruturado e autoaplicável. As informações foram analisadas a partir do modelo de análise de conteúdo proposto por Bardin. Resultados: a exposição/utilização de drogas, hábitos alimentares inadequados, barreiras no acesso em saúde e comportamentos de risco/agravos associados à sexualidade foram as principais vulnerabilidades à saúde na adolescência apontadas pelos participantes.  Apesar de priorizarem a consulta médica e odontológica, mencionaram a importância da enfermagem no acesso às ações de saúde na adolescência, como à vacinação, grupos educativos e avaliação do crescimento/desenvolvimento dos adolescentes. Conclusão: a promoção da saúde dos adolescentes demanda por constante avaliação das situações e níveis de vulnerabilidades à saúde desse grupo através do Programa Saúde na Escola

Vulnerability and access in adolescent health in view of the parents

Objetivo: analisar a percepção de pais sobre vulnerabilidades e necessidades de acesso em saúde na adolescência no município de Contagem/Minas Gerais. Método: Trata-se de estudo descritivo desenvolvido com 94 pais de adolescentes de 12 escolas públicas municipais que responderam a um questionário semiestruturado e autoaplicável. As informações foram analisadas a partir do modelo de análise de conteúdo proposto por Bardin. Resultados: a exposição/utilização de drogas, hábitos alimentares inadequados, barreiras no acesso em saúde e comportamentos de risco/agravos associados à sexualidade foram as principais vulnerabilidades à saúde na adolescência apontadas pelos participantes.  Apesar de priorizarem a consulta médica e odontológica, mencionaram a importância da enfermagem no acesso às ações de saúde na adolescência, como à vacinação, grupos educativos e avaliação do crescimento/desenvolvimento dos adolescentes. Conclusão: a promoção da saúde dos adolescentes demanda por constante avaliação das situações e níveis de vulnerabilidades à saúde desse grupo através do Programa Saúde na Escola

Morphology and topography of the external male genital organs of spotted paca (Cuniculus paca Linnaeus, 1766)

Spotted paca (Cuniculus paca) is a rodent species from the family Cuniculidae, found in South America, from the Orinoco River Basin to Paraguay. Although widely studied with regard to its morphological and reproductive aspects, still there’re no records on the morphology of the male reproductive system in this species. Thus, this study aimed to evaluate not only the macro and microscopic anatomy of the external genital organs in this species, but also their topography. We studied the external genital organs of 10 adult spotted pacas; 5 specimens, fixed in a 10% aqueous formaldehyde solution, were macroscopically studied and from 5 specimens we collected fragments from the reproductive system, for microscopic analysis. The testicles showed a parenchyma structured in seminiferous tubules and the germinal epithelium rested on its basal membrane. These organs were located in the abdominal cavity, the inguinal path, or within the scrotum. Penis, fibroelastic, was located in the pubic region, in caudal direction. Its glans, coated by keratinized epithelium, were covered by the prepuce and, below this, we identified a slender cartilaginous structure with serrated edges. A couple of bone spurs was located into a bag ventral to the urethra, whose mucosa was lined by transitional epithelium. The epididymal duct was balled up in the head, had a body and tail, and its head was lined by pseudo-stratified stereociliated epithelium, and the tail by simple cubic epithelium; from this, the deferent duct stemmed, lined by columnar stratified epithelium

Suplementação de duas fontes de selênio em diferentes níveis na dieta de cachaços e seu efeito sobre a qualidade seminal

A membrana espermática é rica em ácidos graxos poliinsaturados, o que a torna sensível à ação de espécies reativas de oxigênio, que podem prejudicar a qualidade seminal dos cachaços. O objetivo do presente estudo foi avaliar o efeito da suplementação de duas fontes de selênio em diferentes doses. Trinta e cinco cachaços foram distribuídos em quatro grupos: (INOR30) 0,30 ppm de selenito de sódio; (COMP30) 0,30 ppm de metal-aminoácido de selênio; (MISTO15+15) 0,15 ppm de selenito de sódio + 0,15 ppm de metal-aminoácido de selênio e (COMP15) 0,15 ppm de metal-aminoácido de selênio. Os ejaculados dos cachaços foram avaliados durante 22 semanas, resultando em 210 amostras avaliadas para volume, motilidade, pH, presença de aglutinação e alterações morfológicas, e 140 amostras para concentração espermática. Os dados foram analisados com medidas repetidas no tempo em modelo misto, em que o tipo de suplementação de selênio, os períodos de avaliação (um período de duas semanas + cinco períodos de quatro semanas) e suas interações foram os efeitos fixos, e o animal e o funcionário que coletou os ejaculados foram os efeitos aleatórios. Os resultados obtidos demonstraram não haver diferença na suplementação de selênio com as fontes e doses utilizadas. Com isso, foi possível verificar que o metal-aminoácido de selênio na dose de 0,15 ppm promove o mesmo efeito das dietas formuladas com 0,30 ppm de selenito de sódio. Palavras-chave: Antioxidante; Reprodutor suíno; Espermatozoide; Reproduçã

Impairment of adenosine signaling disrupts early embryo development: unveiling the underlying mechanisms

Purinergic signaling has been implicated in many biological functions, including development. In this study, we investigate the functions of extracellular adenosine and adenosine receptors using a mouse embryonic stem cell (ESC) line and morula stages isolated from mouse embryos. Feeder-free mouse ESC was investigated in the absence and presence of the leukemia inhibitory factor (LIF), configuring undifferentiated cells and cells undergoing spontaneous differentiation. High alkaline phosphatase (ALPL) and low CD73 levels resulting in low adenosine (eADO) levels were characteristic for pluripotent cells in the presence of the LIF, while LIF deprivation resulted in augmented adenosine levels and reduced pluripotency marker expression, which indicated differentiation. Tracing ESC proliferation by BrdU labeling revealed that the inhibition of ALPL by levamisole resulted in a decrease in proliferation due to less eADO accumulation. Furthermore, caffeine and levamisole treatment, inhibiting adenosine receptor and eADO accumulation, respectively, reduced ESC migration, similar to that observed in the absence of the LIF. Pharmacological approaches of selective adenosine receptor subtype inhibition triggered specific adenosine receptor activities, thus triggering calcium or MAP kinase pathways leading to differentiation. In line with the in vitro data, mouse embryos at the morula stage were sensitive to treatments with A1 and A3 receptor antagonists, leading to the conclusion that A1 receptor and A3 receptor inhibition impairs proliferation and self-renewal and triggers inappropriate differentiation, respectively. The findings herein define the functions of eADO signaling in early development with implications for developmental disorders, in which adenosine receptors or ectonucleotidase dysfunctions are involved, and which could lead to malformations and miscarriages, due to exposure to caffeine

MEDIDAS MITIGADORAS EM CASO DE ACIDENTES COM RESÍDUO DE PETRÓLEO DO TIPO BORRA OLEOSA – REVISÃO DE LITERATURA

Na busca de demonstrar maneiras adequadas para tratar o resíduo de petróleo (borra oleosa) em casos de derramamentos ou mesmo de pessoas envolvendo o meio ambiente é que está sendo realizada essa revisão literária. A fonte principal de pesquisa foi obtida em dados emitidos pela indústria petrolífera,principal responsável por uma geração considerável deste resíduo, provenientes de suas atividades. O objetivo principal será analizar os riscos que esse resíduo podem causar ao meio ambiente, estudar sua caracterização e seu resíduo final. Foram verificadas através de ficha de emergência emitida pela PETROBRAS, medidas cautelosas a serem adotadas em tais situações, bem como equipamentos a serem utilizados afim de minimizar o risco aos envolvidos e ao meio ambiente. O possível dano ambiental decorrente de atividade petrolífera é de inteira responsabilidade da empresa geradora conforme se pode verificar na legislação vigente, onde preconiza que a responsabilidade civil e penal pelo impacto ambiental ocasionado, e pela segurança e saúde dos trabalhadores é da empresa. Na medida que os produtos químicos são manuseados de forma adequada, respeitando as leis e normas vigentes no país, o impacto ambiental diminuirá consideravelmente

Multíplos hemangiomas hepáticos em lactente jovem: relato de caso / Multiple hepatic hemangiomas in young infants: case report

O fígado é o principal sítio de hemangiomas viscerais, e o hemangioma hepático é o tumor hepático benigno mais comum na infância, apresentando amplo espectro de sintomas clínicos desde assintomáticos até complicações graves. Assim o presente relato  tem como objetivo o estudo sobre um caso de  hemangioma hepático difuso em lactente jovem no município de Marabá, no Estado do Pará. Como conclusão ressalta-se que a utilização do propranolol pela paciente, mostrou-se eficaz e seguro ao longo de 12 meses de tratamento, sem apresentação de efeitos colaterais e com redução significativa dos hemangiomas

Clinical Manifestations and Complications of Children With COVID-19 Compared to Other Respiratory Viral Infections: A Cohort Inpatient Study From Rio de Janeiro, Brazil

IntroductionThe coronavirus disease-2019 (COVID-19) clinical manifestations in children and adolescents are diverse, despite the respiratory condition being the main presentation. Factors such as comorbidities and other respiratory infections may play a role in the initial presentation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This study aims to describe the epidemiological aspects, clinical, and laboratory manifestations of pediatric patients admitted to a tertiary pediatric hospital in Rio de Janeiro, diagnosed with COVID-19, and compare these with other viral conditions during the first year of the SARS-CoV-2 pandemic.MethodsAll patients under 18 years of age that were admitted with upper airway infection were enrolled and followed up for 30 days. The main dependent variable was the laboratorial diagnosis of SARS-CoV-2, and independent variables were studied through logistic regression.ResultsA total of 533 patients were recruited, and 105 had confirmed SARS-CoV-2 infection. Detection of other viruses occurred in 34% of 264 tested participants. Six patients died (two in SARS-CoV-2 infected group). The variables independently associated with COVID-19 were older age (OR = 1.1, 95% CI = 1.0–1.1), lower leukocytes count at entry (OR = 0.9, 95% CI = 0.8–0.9), and contact with suspected case (OR = 1.6, 95% CI = 1.0–2.6). Patients with COVID-19 presented higher odds to be admitted in an intensive care unit (OR = 1.99, 95% CI = 1.08–3.66).ConclusionsEven during the SARS-CoV-2 pandemic, several other respiratory viruses were present in admitted pediatric patients. Variables associated with COVID-19 infection were older age, lower leukocytes count at entry, and a domiciliary suspect contact. Although patients with COVID-19 were more frequently admitted to ICU, we did not observe higher mortality in this group

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London