Use of Eye Tracking as an Innovative Instructional Method in Surgical Human Anatomy

Tobii glasses can record corneal infrared light reflection to track pupil position and to map gaze focusing in the video recording. Eye tracking has been proposed for use in training and coaching as a visually guided control interface. The aim of our study was to test the potential use of these glasses in various situations: explanations of anatomical structures on tablet-type electronic devices, explanations of anatomical models and dissected cadavers, and during the prosection thereof. An additional aim of the study was to test the use of the glasses during laparoscopies performed on Thiel-embalmed cadavers (that allows pneu- moinsufflation and exact reproduction of the laparoscopic surgical technique). The device was also tried out in actual surgery (both laparoscopy and open surgery)

Phishing websites detection using a novel multipurpose dataset and web technologies features

[EN] Phishing attacks are one of the most challenging social engineering cyberattacks due to the large amount of entities involved in online transactions and services. In these attacks, criminals deceive users to hijack their credentials or sensitive data through a login form which replicates the original website and submits the data to a malicious server. Many anti-phishing techniques have been developed in recent years, using different resource such as the URL and HTML code from legitimate index websites and phishing ones. These techniques have some limitations when predicting legitimate login websites, since, usually, no login forms are present in the legitimate class used for training the proposed model. Hence, in this work we present a methodology for phishing website detection in real scenarios, which uses URL, HTML, and web technology features. Since there is not any updated and multipurpose dataset for this task, we crafted the Phishing Index Login Websites Dataset (PILWD), an offline phishing dataset composed of 134,000 verified samples, that offers to researchers a wide variety of data to test and compare their approaches. Since approximately three-quarters of collected phishing samples request the introduction of credentials, we decided to crawl legitimate login websites to match the phishing standpoint. The developed approach is independent of third party services and the method relies on a new set of features used for the very first time in this problem, some of them extracted from the web technologies used by the on each specific website. Experimental results show that phishing websites can be detected with 97.95% accuracy using a LightGBM classifier and the complete set of the 54 features selected, when it was evaluated on PILWD dataset.SIINCIBEUniversidad de Leó

Use of Eye-Tracking Technology by Medical Students Taking the Objective Structured Clinical Examination: Descriptive Study

Background: The objective structured clinical examination (OSCE) is a test used throughout Spain to evaluate the clinical competencies, decision making, problem solving, and other skills of sixth-year medical students. Objective: The main goal of this study is to explore the possible applications and utility of portable eye-tracking systems in the setting of the OSCE, particularly questions associated with attention and engagement. Methods: We used a portable Tobii Glasses 2 eye tracker, which allows real-time monitoring of where the students were looking and records the voice and ambient sounds. We then performed a qualitative and a quantitative analysis of the fields of vision and gaze points attracting attention as well as the visual itinerary. Results: Eye-tracking technology was used in the OSCE with no major issues. This portable system was of the greatest value in the patient simulators and mannequin stations, where interaction with the simulated patient or areas of interest in the mannequin can be quantified. This technology proved useful to better identify the areas of interest in the medical images provided. Conclusions: Portable eye trackers offer the opportunity to improve the objective evaluation of candidates and the self-evaluation of the stations used as well as medical simulations by examiners. We suggest that this technology has enough resolution to identify where a student is looking at and could be useful for developing new approaches for evaluating specific aspects of clinical competencies

Iahris: New Software to Assess Hydrologic Alteration

Indicators of Hidrologic Alteration in RIverS (IAHRIS) is a software designed to fulfill: 1. Parameters for the characterization of the natural or regulated flow regime, in a section of the river. These parameters evaluate those aspects of the flow regime with the highest environmental meaning (magnitude, variability, seasonality and duration). Their definition has given priority to the consideration of the singular characteristics of the Mediterranean regimes. 2. If the user enters data of the natural flow regime and data for any other flow regime in the same section or reach (altered regime, environmental regime, management scenario, …) the software calculates, furthermore, a set of indicators that assess the degree of hydrologic alteration in comparison with the natural regime. These indicators of alteration have been defined attending to the CIS-WFD recommendations for the Ecological Quality Ratios. The software requires, at least, 15 entire years with data (daily average flows and/or monthly volumes). The type of data entered in IAHRIS determines, directly, the results accomplished. In particular, they depend on the data periodicity –daily or monthly-, and the simultaneous character of the data associated to the natural and the altered flow regimes. IAHRIS is free software, available at the website of the Spanish Ministry of the Environment

Use of "ChemSensor" as an early discrimination tool of Iberian pig semen according to their freezability

Para favorecer el uso de dosis de inseminación de semen de porcino congelado-descongelado a nivel comercial, sería interesante conocer de antemano si el semen de verraco congelará bien o mal. El objetivo de este estudio fue evaluar el 'ChemSensor' (cromatógrafo de gases-masas unido a un software de análisis quimiométrico) como herramienta precoz de discriminación entre eyaculados según su congelabilidad. Para ello se utilizaron 33 eyaculados de verracos de raza Ibérica de los cuales se cogió una alícuota de 1 ml de semen y se analizó con el 'ChemSensor', el resto del eyaculado fue congelado-descongelado usando un protocolo estandarizado, para determinar su congelabilidad (buenos y malos congeladores) en función del porcentaje de espermatozoides con la membrana plasmática intacta y el porcentaje de espermatozoides móviles totales post-descongelación. Para el análisis con el 'ChemSensor', las muestras se volatilizaron e ionizaron descomponiéndolas en diferentes iones con un tamaño determinado, que se usaron como variables de discriminación, para separar los eyaculados en función de su congelabilidad. El 'ChemSensor' fue capaz de discriminar todos los eyaculados de los buenos congeladores; y dentro del grupo de los malos congeladores solamente una muestra fue clasificada erróneamente. Debido al reducido número de muestras, la distancia obtenida entre grupos (2,62), aunque no muy elevada, podría considerarse como significativa, aunque sería necesario un mayor número de muestras para poder crear un modelo matemático más robusto. En conclusión, el 'ChemSensor' es una posible herramienta adecuada para la discriminación precoz de eyaculados de cerdo Ibérico en función de su congelabilidad

Pharmacokinetics evaluation of nimotuzumab in combination with doxorubicin and cyclophosphamide in patients with advanced breast cancer

EGFr (Epidermal growth factor receptor) overexpression has been detected in many tumors of epithelial origin, specifically in breast cancer and it is often associated with tumor growth advantages and poor prognosis. The nimotuzumab is a genetically engineered humanized MAb (monoclonal antibody) that recognizes an epitope located in the extracellular domain of human EGFr. The aim of this study was to assess the pharmacokinetics of nimotuzumab in patients with locally advanced breast cancer who are receiving neoadyuvant therapy combined with the AC chemotherapy regimen (i.e., 60 mg/m2 of Doxorubicin and 600 mg/m2 of Cyclophosphamide in 4 cycles every 21 days). A single center, non-controlled, open Phase I clinical trial, with histopathological diagnosis of locally advanced stage III breast cancer, was conducted in 12 female patients. Three patients were enrolled at each of the following fixed dose levels: 50, 100, 200 and 400 mg/week. Multiple intermittent short-term intravenous infusions of nimotuzumab were administered weekly, except on weeks 1 and 10, when blood samples were drawn for pharmacokinetic assessments. Nimotuzumab showed dose-dependent kinetics. No anti-idiotypic response against nimotuzumab was detected in blood samples of participants. There was not interaction between the administration of nimotuzumab and chemotherapy at the dose levels studied. The optimal biological doses ranging were estimated to be 200 mg/weekly to 400 mg/weekly

Linear Algebra Based Control: Application to a Second Order Chained FormSystem

Control of underactuated systems with non-holonomic constraints has been an issue of interest in recent years. These systems are hard to control because their linearization makes them uncontrollable and current approaches generally involve complex calculations.In this manuscript,a controller for trajectory tracking and positioning for a second-order chained form system using a simple approach based on linear algebra is proposed.The control law is formulated by setting two of the six variables trajectories, while the other four are calculated assuming the equations system has an exact solution, and ensuring the error tendsto zero. The stability of the proposed control system is demonstrated through the KhalilLemma, and simulations show theperformance of the controller.Fil: Rodriguez Aguilar, Leandro Pedro Faustino. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Ingeniería Química; ArgentinaFil: Fernández Puchol, María Cecilia. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Ingeniería Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; ArgentinaFil: Sanchez, Mabel Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaFil: Scaglia, Gustavo Juan Eduardo. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Ingeniería Química; Argentina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Ingeniería Química; Argentin

A new multi-criteria optimization strategy for shared control in wheelchair assisted navigation

In todays aging society, many people require mobility assistance, that can be provided by robotized assistive wheelchairs with a certain degree of autonomy when manual control is unfeasible due to disability. Robot wheelchairs, though, are not supposed to be completely in control because lack of human intervention may lead to loss of residual capabilities and frustration. Most of these systems rely on shared control, which typically consists of swapping control from human to robot when needed. However, this means that persons never deal with situations they find difficult. We propose a new shared control approach to allow constant cooperation between humans and robots, so that assistance may be adapted to the user’s skills. Our proposal is based on the reactive navigation paradigm, where robot and human commands become different goals in a Potential Field. Our main novelty is that human and robot attractors are weighted by their respective local efficiencies at each time instant. This produces an emergent behavior that combines both inputs in an efficient, safe and smooth way and is dynamically adapted to the user’s needs. The proposed control scheme has been successfully tested at hospital Fondazione Santa Lucia (FSL) in Rome with several volunteers presenting different disabilities

Informe sobre la producción científica de Cuba y El Caribe en revistas iberoamericanas de acceso abierto en redalyc.org 2005-2011

Objetivo: Proporcionar información sobre el Perfil de Producción Científica de Cuba y El Caribe en revistas del acervo redalyc.org para el periodo 2005-2011, a fin de conocer cuáles son tanto las tendencias como el comportamiento de las estrategias de comunicación y de colaboración que registran los artículos producidos por los investigadores cubanos y caribeños.Método: Se estudia la producción científica de 800 revistas iberoamericanas de acceso abierto durante 2005-2011, a partir de un modelo de análisis centrado en entidades de producción y comunicación, las cuales permiten generar un Perfil de Producción Científica según los indicadores de: Producción (P), Producción en Colaboración (PC) y Colaboración (C), aplicados a un núcleo de 145,515 artículos científicos que forman parte del acervo redalyc.org.Resultados: La información que constituye la producción científica de Cuba y El Caribe durante 2005-2011, forma parte de un estudio más amplio realizado al acervo redalyc.org, el cual abarca a 13,414 instituciones de 146 países. La producción de la región caribeña asciende a 7,967 artículos que corresponden a una aportación de 5.4% del total analizado, de estos, 23.8% fue publicado en revistas del extranjero, en tanto, 13.5% corresponden a ciencias sociales, 79% a ciencias, así como artes y humanidades con 0.5% y multidisciplinarias con 6.9%.En tanto, las instituciones caribeñas con mayor aporte a la producción científica son la Universidad de Ciencias Médicas de la Habana, la Universidad de la Habana y el Instituto de Ciencia Animal; mientras que 81% de los trabajos firmados por autores nacionales se han realizado en colaboración principalmente interna de tipo institucional (52.8%), y donde la participación de autores extranjeros se vincula principalmente con México, España, Brasil y Colombia que en conjunto representan 63.6% de la producción de la región caribeña en colaboración con otros países

CCL2-Expressing Astrocytes Mediate the Extravasation of T Lymphocytes in the Brain. Evidence from Patients with Glioma and Experimental Models In Vivo

CCL2 is a chemokine involved in brain inflammation, but the way in which it contributes to the entrance of lymphocytes in the parenchyma is unclear. Imaging of the cell type responsible for this task and details on how the process takes place in vivo remain elusive. Herein, we analyze the cell type that overexpresses CCL2 in multiple scenarios of T-cell infiltration in the brain and in three different species. We observe that CCL2+ astrocytes play a part in the infiltration of T-cells in the brain and our analysis shows that the contact of T-cells with perivascular astrocytes occurs, suggesting that may be an important event for lymphocyte extravasation