Expanding congenital abnormalities of the kidney and urinary tract (CAKUT) genetics: basonuclin 2 (BNC2) and lower urinary tract obstruction

his work was supported by FIS PI16/02057, PI19/00588, PI19/00815, DTS18/00032, REDinREN RD016/0009 Fondos FEDER, ERA-PerMed-JTC2018 (KIDNEY ATTACK AC18/00064 and PERSTIGAN AC18/00071), Sociedad Española de Nefrología, FRIAT, and Comunidad de Madrid B2017/BMD-3686 CIFRA2 and Rio Hortega to MV Perez-Gome

MAP17 (PDZK1IP1) and pH2AX are potential predictive biomarkers for rectal cancer treatment efficacy

Rectal cancer represents approximately 10% of cancers worldwide. Preoperative chemoradiotherapy increases complete pathologic response and local control, although it offers a poor advantage in survivorship and sphincter saving compared with that of radiotherapy alone. After preoperative chemoradiotherapy, approximately 20% of patients with rectal cancer achieve a pathologic complete response to the removed surgical specimen; this response may be related to a better prognosis and an improvement in disease-free survival. However, better biomarkers to predict response and new targets are needed to stratify patients and obtain better response rates. MAP17 (PDZK1IP1) is a small, 17 kDa non-glycosylated membrane protein located in the plasma membrane and Golgi apparatus and is overexpressed in a wide variety of human carcinomas. MAP17 has been proposed as a predictive biomarker for reactive oxygen species, ROS, inducing treatments in cervical tumors or laryngeal carcinoma. Due to the increase in ROS, MAP17 is also associated with the marker of DNA damage, phosphoH2AX (pH2AX). In the present manuscript, we examined the values of MAP17 and pH2AX as surrogate biomarkers of the response in rectal tumors. MAP17 expression after preoperative chemoradiotherapy is able to predict the response to chemoradiotherapy, similar to the increase in pH2AX. Furthermore, we explored whether we can identify molecular targeted therapies that could help improve the response of these tumors to radiotherapy. In this sense, we found that the inhibition of DNA damage with olaparib increased the response to radio- and chemotherapy, specifically in tumors with high levels of pH2AX and MAP17.Spanish Ministry of Economy and Competitivity, Plan Estatal de I+D+I 2013–2016, ISCIII (Fis: PI15/00045) and CIBER de Cáncer (CB16/12/00275)co-funded by FEDER from Regional Development European Funds (European Union), Consejería de Ciencia e Innovación (CTS-1848)Consejería de Salud of the Junta de Andalucía (PI-0096–2014)

Correlational study on cyberbullying and social abilities in intercultural teenagers

This article analyzes the relationship between cyberbullying profile by racist reasons and social abilities in a group of intercultural teenagers living in Spain (N = 1478). The study includes participants aged between 12 and 16 years old (M = 13.99; SD = 1.352). Of these, 738 were male (49.9%) and 740 were female (50.1%). A correlational study was carried out using online tools with suitable psychometrics parameters (content-construct validity and reliability). The first one was a scale that measured social abilities, and the second one evaluated racist or xenophobic cyberbullying, differentiating the victim and aggressor profiles. The results indicated five main findings: (1) generally, the participants analyzed present all their social abilities; (2) for the most part, these participants do not normally experience cyberbullying; (3) a positive correlation exists between the majority of social abilities analyzed and the cybervictim profile. It was also observed a negative correlation between the social ability associated with the ability of making requests and this profile; (4) there is a positive correlation among the six social abilities analyzed and the cyberaggressor profile; (5) the racist or xenophobic cyberbullying are driven not only by the absence of social abilities, but in some cases, they are also driven by socio-demographic variables (i.e., age and gender). Likewise, this work shows how the absence of some social abilities in some participants involve racist or xenophobic experiences as victims and as aggressors, which may be of interest for the analysis of teenagers’ behavior in intercultural contexts, as well as according to age and gender. More transcultural research need to be carried out to know the global perspective of the link between social abilities and the different profiles of racist and xenophobic cyberbullying, framed in the context of social psychology and studies of mass communication.Autonomous City of Melill

Cyberbullying Analysis in Intercultural Educational Environments Using Binary Logistic Regressions

The goal of this study is to analyze how religion, ethnic group, and race influence the likelihood of becoming either a cybervictim or cyberbully in intercultural educational environments. In the research, 755 students in secondary education were analyzed in the south of Spain through the Cyberbullying Scale for students with Cultural and Religious Diversity (CSCRD). The analyses were carried out using the Statistical Package SPSS and the STATA software. The results obtained from the Kruskal–Wallis H test showed significant differences according to these aspects, for both the cybervictim and cyberbully parameters. The results stemming from binary logistic regressions confirmed such differences and regarded those students who belong to the Muslim religion, the gypsy ethnic group and the Asian race as being more likely to become cybervictims. Furthermore, these analyses showed that Gypsy and Asian students were also more likely to be cyberbullies than other groups. The main conclusions state that minority groups are more likely to suffer cyberbullying in intercultural educational environments, and that students from these groups are also more likely to become cyberbullies

Veritablement vetements

Este proyecto trabaja con ropa de segunda mano como materia prima para elaborar una serie de “Prendas Participativas”, las cuales entiendo como máquinas, que activan relaciones determinadas entre personas: acciones y gestos que remiten a distintos vínculos interpersonales. Estas piezas aparecen en dos estados, que denomino “activación inmediata” y “activación”. Asimismo, mi proceso implica otras piezas que son videográficas, y me sirven para indagar en la forma activada de las prendas. Se presentan con un carácter que prima la intimidad, mostrando una serie de acciones cotidianas que habitualmente nos pasan desapercibidas pero aquí construyen el discurso alegórico con el otro. Tanto las prendas participativas como los vídeos, dibujos y etiquetas son partes complementarias del mismo proceso de investigación, dialogan entre sí y me permiten ir desarrollando el discurso que me interesa. La compresión de las Prendas Participativas, supone involucrarse y experimentarlas ya sea física o mentalmente, mediante un proceso abierto de descubrimiento inmanente a la realización de un acto mientras se construye el discurso con el otro. Se crea un lugar cuya condición nos hace sentirnos similares y a la vez diferentes, donde nos encontramos familiares pero distantes. Muchas veces el vínculo que creamos con la ropa que nos ponemos, que podemos cambiar, o guardar, o elegir cada día, es muy parecido al que creamos con las personas, aunque las ropas son cosas y las personas no. Así, con mis PP quiero hacer visibles relaciones de ayuda, poder, cariño, afecto, violencia, etc. que ocurren entre las personas cuando nos tratamos como si fueramos cosas

Educational Environments with Cultural and Religious Diversity: Psychometric Analysis of the Cyberbullying Scale

The objective of this research is to adapt and validate a useful instrument to diagnose cyberbullying, provoked by intolerance towards cultural and religious diversity, identifying the profile of the aggressor and the victim. The study was carried out using the Delphi technique, exploratory factor analysis (EFA), and confirmatory factor analysis (CFA). The selected sample was composed of 1478 adolescents, all students from Compulsory Secondary Education of Spain. The instrument items were extracted from relevant scales on the topic. The initial questionnaire was composed of 52 items and three underlying constructs. After validation with EFA (n = 723), the structure was checked, and the model was later corroborated with CFA (n = 755) through structural equations (RMSEA = 0.05, CFI = 0.826, TLI = 0.805). The reliability and internal consistency of the instrument were also tested, with values for all dimensions being higher than 0.8. It is concluded that this new questionnaire has 38 items and three dimensions. It has an acceptable validity and reliability, and can be used to diagnose cyberbullying caused by the non-acceptance of cultural and religious diversity in Compulsory Secondary Education students.Part of this work has been funded by the Research Project Competitive “Values for intercultural coexistence in the students of the Autonomous City of Melilla. An intervention proposal”

Adaptation and validation of the social skills scale for intercultural primary school pupils

In recent decades, large migratory movements have been taking place, which has turned Spain into a culturally diverse country. For this reason, the present research focuses on social skills, which are considered of utmost importance in different educational contexts. To this end, the aim was to adapt and validate a scale to diagnose social skills in young people aged 6 to 12 years (M = 9.65 years; SD = 1.395). Of these, 460 (60.4%) were boys and 301 (39.60%) girls. For this purpose, a methodology is followed that involves the judgement of experts in the field, followed by an exploratory factor analysis (EFA) and then a confirmatory factor analysis (CFA). The sample chosen for the study is made up of 1564 young people, Primary School students from different Andalusian localities that constitute border cities in the south of Spain, and which have a great cultural, ethnic and religious diversity that is reflected in their classrooms. The items of the scale were obtained from relevant questionnaires on the subject under study, initially containing 33 items and 6 underlying constructs. After validation of the AFE (n = 761), the structure is verified and the model is corroborated by CFA (n = 803) with structural equations (RMSEA = 0.04; CFI = 0.77; TLI = 0.73). Finally, the reliability and internal consistency of the instrument is examined, obtaining values above 0.6 for all dimensions. As a result, a new scale composed of 33 items and 5 dimensions is obtained, with psychometric properties that give it validity and reliability. In conclusion, we present a useful resource for teachers that allows them to diagnose the social skills of Primary School students in schools characterised by their great cultural diversity and among the peer group

Relaciones entre las especies arbóreas, sus características morfológicas y los tipos de suelo, y las afectaciones en la infraestructura vial de la ciudad de Bogotá

Se realizó en la ciudad de Bogotá donde se identificaron 4 zonas, según el mapa de zonificación geotécnica Al cubrir el terreno con una capa asfáltica o pavimentada se impide la evaporación, como consecuencia se produce un aumento en la humedad del suelo respecto de las áreas no cubiertas (Acuña y Salazar 1997). Por esta razón los árboles dirigen sus raíces hacia las primeras buscando la mayor humedad causando la desecación y la contracción del suelo (Beltrán L, 1994). Se busca identificar si existen relaciones entre las especies arbóreas, sus características morfológicas, los tipos de suelo, y las afectaciones en la infraestructura vial de la ciudad de Bogotá. Para desarrollarlo se identificaron avenidas para cada zona con presencia de árboles que generen afectación sobre la infraestructura vial de Bogotá, Se caracterizó la especie y la morfología de 200 individuos (50 por zona), determinando: DAP (diámetro a la altura del pecho), Altura Área de proyección de la copa, Distancia al bordillo, Tipo de daño y Cantidad de grietas para finalmente determinar las relaciones causa efecto entre las características morfológicas de las especies y la zona en que se hacen presentes y los daños a la infraestructura. Se recomienda tener en cuenta el tipo de material que rodea al árbol, ya que el comportamiento de algunos materiales es diferente según la humedad y fuerza ejercida por la raíz. Y de este modo seleccionar para cada zona grupos de igual cantidad de individuos que presenten características semejantes en cuanto entorno, especie y edad.It was held in Bogotá where 4 areas were identified according to the map of geotechnical zoning by covering the soil with an asphalt or paved layer evaporation as a result there is an increase in soil moisture in respect of the areas is precluded covers (Acuña and Salazar 1997). For this reason the trees roots to direct their first seeking greater moisture causing drying and shrinkage of the soil (Beltrán L, 1994). It seeks to identify whether relationships between tree species, their morphological characteristics, soil types, and the effects on road infrastructure in Bogotá there. To develop avenues for each zone with the presence of trees that generate involvement on road infrastructure Bogotá identified the species and morphology of 200 individuals (50 zone) was characterized by determining : DBH (diameter at breast height) Height projection area of the glass , Distance from curb damage type and number of cracks to finally determine the cause and effect relationships between the morphological characteristics of the species and the area in which they are present and damage to infrastructure. It is recommended to consider the type of material that surrounds the tree, since the behavior of some materials is different depending on humidity and force exerted by the root. And so for each zone selected groups of equal number of individuals who have characteristics similar as environment, species and age.Ecólogo (a)Pregrad

From Private Company to Water User Association and Natural Park over a Century: The Case of Riegos de Levante, Izquierda del Segura (Spain)

This work examines the transformations occurred with the shift from private company to water user association and natural park, looking at one collective irrigation system located in Alicante province (Spain): Riegos de Levante, Izquierda del Segura, one of the most extensive irrigation areas in Europe. Between 1918 and 2018, a process of change and transformation of both landscape and institutions occurred, considering: infrastructure expansion and its operation, the transfer of irrigation management responsibilities to water user association, after years of financial operations with water, thanks to state intervention, the coexistence of traditional agriculture with the modernisation of the irrigation systems, the history of an irrigation reservoir which was transformed into a natural site in 1988, or the evolution of the composition of water resources, taking into account the arrival of the Tajo-Segura transfer waters from the year 1979. The general objective is to understand key factors driving these changes, by means of a paradigmatic case study, as well as to identify policymaking and context-relevant dynamics that could enable it.This research was funded by the CampusHabitat5U network of excellence of Valencian public universities (https://iuaca.ua.es/es/campushabitat5u.html) and the Cátedra del Agua of the University of Alicante and the Diputación Provincial de Alicante (https://catedradelaguaua.org/)

The Sustainability of Public Social Services: A Qualitative Study

[EN] The 2008 global economic crisis heightened social inequality and drastically reduced equal opportunities for many people. It had negative consequences for social regulation in many European countries, which have dismantled their public social policies. The objective of the study was to describe social workers’ perceptions of their lived experiences in di erent areas of the public social services system. A qualitative study was developed, based on a hermeneutic approach. Six in-depth interviews and two focus groups were conducted with 20 social workers employed by community social services and the Andalusian public health service (Spain). The professionals agreed that the public social services system has been eroded, that the lack of resources has consequences for workers and the general public alike, and that the public authorities and the administration are responsible for this situation. Social services have become distributors of scarce resources rather than a social protection system that empowers and accompanies the most vulnerable. The system must provide the necessary resources and structures so that they can escape the situation of poverty, exclusion and social injustice.S