Utilización de la cestilla de Moss en el tratamiento de fracturas patológicas vertebrales

Las fracturas patológicas vertebrales pueden inducir radículo o mielopatía compresiva, inestabilidad y deformidad, de tal forma que el objetivo del tratamiento consistiría en restablecer lo más rápidamente posible la anatomía y función. En este sentido la utilización de una malla cilindrica de titanio como la «cestilla de Moss» consigue una estabilidad inmediata y permite la carga precoz. Presentamos un estudio retrospectivo de 6 pacientes afectos de fractura patológica vertebral intervenidos mediante abordaje anterior y estabilización instrumentada combinada con la «cestilla de Moss» rellena de injerto óseo o cemento acrílico. La valoración clínica se realiza subjetivamente por la presencia de dolor y neurológicamente según los grados de Frankel pre y postoperatorios. Radiológicamente se valora la corrección de la cifosis/lordosis/acuñamiento según el método de Cobb. La utilización de la «cestilla de Moss» en fracturas patológicas vertebrales consigue una estabilidad completa sin dependencia de la fusión ósea.Pathological spinal fractures could induce neurological deficit, instability and deformity. Therefore, the objective of the treatment consists of re-establishing the most quickly possible the anatomy and normal function. In this sense, the utilization of a cylindrical mesh of titanium, like the Moss's mesh, provide an immediate stability permiting early loading. We report a retrospective study of 6 patients with pathological spinal fracture operated by anterior decompression and spine stabilization using the Moss's mesh padded of bone graft acrylic cement. Clinical assessment was made subjectively for the presence of pain and neurologic ally according to pre and postoperatively Frankel's grades. The correction of the kyphosis, lordosis and vertebral collapse was assessed according to the Cobb's method. The utilization of the Moss's mesh in pathological spinal fractures provides a complete stability without dependence of the status of bone fusion

Current and prospective pharmacological targets in relation to antimigraine action

Migraine is a recurrent incapacitating neurovascular disorder characterized by unilateral and throbbing headaches associated with photophobia, phonophobia, nausea, and vomiting. Current specific drugs used in the acute treatment of migraine interact with vascular receptors, a fact that has raised concerns about their cardiovascular safety. In the past, α-adrenoceptor agonists (ergotamine, dihydroergotamine, isometheptene) were used. The last two decades have witnessed the advent of 5-HT1B/1D receptor agonists (sumatriptan and second-generation triptans), which have a well-established efficacy in the acute treatment of migraine. Moreover, current prophylactic treatments of migraine include 5-HT2 receptor antagonists, Ca2+ channel blockers, and β-adrenoceptor antagonists. Despite the progress in migraine research and in view of its complex etiology, this disease still remains underdiagnosed, and available therapies are underused. In this review, we have discussed pharmacological targets in migraine, with special emphasis on compounds acting on 5-HT (5-HT1-7), adrenergic (α1, α2, and β), calcitonin gene-related peptide (CGRP 1 and CGRP2), adenosine (A1, A2, and A3), glutamate (NMDA, AMPA, kainate, and metabotropic), dopamine, endothelin, and female hormone (estrogen and progesterone) receptors. In addition, we have considered some other targets, including gamma-aminobutyric acid, angiotensin, bradykinin, histamine, and ionotropic receptors, in relation to antimigraine therapy. Finally, the cardiovascular safety of current and prospective antimigraine therapies is touched upon

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Batch Mesophilic Anaerobic Co-digestion of Spent Goat Batch Mesophilic Anaerobic Co-digestion of Spent Goat Straw Bedding and Goat Cheese Whey: Comparison with the Mono-digestion of the Two Sole Substrates

Spent livestock bedding is a valuable resource for the production of green energy (methane) in rural areas. Comparison and evaluation of batch anaerobic digestion and co-digestion of different mixtures of goat straw bedding (SGSB) and goat cheese whey were carried out. Biochemical methane potential (BMP) tests of the 100% SGSB, 95% SGSB-5% whey, 90% SGSB-10% whey, 85% SGSB-15% whey and 100% whey were found to be 423 ± 7, 354 ± 9, 371 ± 2, 293 ± 1, 274 ± 2 mL CH4 g−1 VS. Two different kinetic models were evaluated. The logistic model revealed a decrease in the maximum methane production rate (Rm) from 34.7 ± 1.5 to 14.1 ± 0.9 mL CH4 g−1 VS·d−1 when the percentage of whey in the mixture increased from 0 to 15% as a consequence of the increased ammonia released during the co-digestion of increased concentrations of whey. The lowest value for the maximum methane production predicted by the model (P) was found for 100% whey (274 ± 10 mL CH4 g−1 VS). A two-substrate model was applied to describe the evident existence of rapid and slowly degradable material. Regarding the hydrolysis kinetic constants predicted by this model, considerable increases in the rapid biodegradation stage (krapid) were observed when comparing to the values found for the slow (kslow) biodegradation stage in all the cases tested. The increases between both constants rose from 5 to 42% when the percentage of whey increased.Junta de Andalucía RNM-19

Batch mesophilic anaerobic co-digestion of spent goat batch mesophilic anaerobic co-digestion of spent goat straw bedding and goat cheese whey: Comparison with the mono-digestion of the two sole substrates

4 Tablas.-- 2 FigurasSpent livestock bedding is a valuable resource for the production of green energy (methane) in rural areas. Comparison and evaluation of batch anaerobic digestion and co-digestion of different mixtures of goat straw bedding (SGSB) and goat cheese whey were carried out. Biochemical methane potential (BMP) tests of the 100% SGSB, 95% SGSB-5% whey, 90% SGSB-10% whey, 85% SGSB-15% whey and 100% whey were found to be 423 ± 7, 354 ± 9, 371 ± 2, 293 ± 1, 274 ± 2 mL CH4 g−1 VS. Two different kinetic models were evaluated. The logistic model revealed a decrease in the maximum methane production rate (Rm) from 34.7 ± 1.5 to 14.1 ± 0.9 mL CH4 g−1 VS·d−1 when the percentage of whey in the mixture increased from 0 to 15% as a consequence of the increased ammonia released during the co-digestion of increased concentrations of whey. The lowest value for the maximum methane production predicted by the model (P) was found for 100% whey (274 ± 10 mL CH4 g−1 VS). A two-substrate model was applied to describe the evident existence of rapid and slowly degradable material. Regarding the hydrolysis kinetic constants predicted by this model, considerable increases in the rapid biodegradation stage (krapid) were observed when comparing to the values found for the slow (kslow) biodegradation stage in all the cases tested. The increases between both constants rose from 5 to 42% when the percentage of whey increased.The authors wish to thank to the regional government of Andalucía, Junta de Andalucía, Consejería de Economía y Conocimiento (Project of Excellence RNM-1970) for providing financial support. N.F. Puntano also wishes to thank the academic mobility and exchange program (PIMA). The PIMA program is a mobility initiative for undergraduate students promoted by the Ibero-American States Organization. The authors also wish especially to thank Manuel Vázquez (Sierra del Romero) for his contribution.Peer reviewe

El biogás: un nuevo producto caprino

3 Páginas.-- 2 Figuras.-- 1 TablaDestaca el conjunto de sinergias positivas que el desarrollo del biogás tiene para el conjunto de la economía, especialmente en cuatro ámbitos: economía circular, política agroindustrial, política ambiental y política energética; dado que el proceso de digestión anaerobia integraría de manera simultánea la reducción de emisiones, la gestión de residuos y materiales generados en el entorno agro-ganadero y la generación de energía renovable.N

Procesos urbanos en acción : ¿desarrollo de ciudades para todos? Volumen III

Con el tercer volumen de la Colección Ciudades de la Gente titulado Procesos urbanos en acción: ¿desarrollo de ciudades para todos?, se pretende descubrir y poner de manifiesto elementos de reflexión que le permitan a las y los lectores comprender los diversos significados del trabajo universitario, en especial el vinculado a la investigación científico-social de los comúnmente llamados barrios populares, en donde viven los pobres urbanos, quienes a nuestro juicio han creado uno de los componentes más importantes en la estructura de nuestras ciudades, los asentamientos populares