TP51 126. Paciente Con Enfermedad Coronaria y Disección Aórtica Iatrogénica Tras Cateterismo: Utilidad de la Cirugía Sin Circulación Extracorpórea

Presentamos el caso de una mujer de 63 años sin antecedentes personales de interés, salvo hábito tabáquico, que acude a nuestro hospital por presentar dolor centrotorácico de características anginosas tras un esfuerzo moderado. El electrocardiograma (ECG) muestra elevación de ST en cara inferior, por lo que se decide realizar cateterismo urgente en el que se objetiva enfermedad significativa de tronco coronario izquierdo (lesión de 70% en tronco coronario izquierdo [TCI] distal) y dos vasos: 90% arteria descendente anterior media y 100% en arteria coronaria derecha media. Se intenta realizar intervencionismo sobre la lesión de la coronaria derecha (CD) que resulta fallido al no conseguir progresar la guía intracoronaria a través de la lesión. Además, durante el procedimiento se produce disección iatrogénica en la raíz aórtica a nivel del seno de Valsalva derecho, contenida y no progresiva. La paciente ingresa en unidad coronaria para monitorización y tratamiento antianginoso. En ecocardiograma transtorácico se objetiva acinesia inferolateral.Se indica realización de intervención quirúrgica de revascularización miocárdica precozmente. En cuanto a la disección iatrogénica de aorta, dado que es contenida y no progresiva, se decide manejo conservador. Se realiza revascularización miocárdica sin circulación extracorpórea, evitando de este modo toda manipulación sobre la aorta enferma. La paciente evolucionó de forma favorable, sin incidencias durante el postoperatorio.La primera angiotomografía computarizada (angio-TC) torácica de control realizada 15 días tras la realización del cateterismo ya no objetiva ninguna imagen compatible con disección aórtica.Un año después de la cirugía la paciente permanece asintomática y sin presentar complicaciones

The Relationship between Choline Bioavailability from Diet, Intestinal Microbiota Composition, and Its Modulation of Human Diseases

© 2020 by the authors.Choline is a water-soluble nutrient essential for human life. Gut microbial metabolism of choline results in the production of trimethylamine (TMA), which, upon absorption by the host is converted into trimethylamine-N-oxide (TMAO) in the liver. A high accumulation of both components is related to cardiovascular disease, inflammatory bowel disease, non-alcoholic fatty liver disease, and chronic kidney disease. However, the relationship between the microbiota production of these components and its impact on these diseases still remains unknown. In this review, we will address which microbes contribute to TMA production in the human gut, the extent to which host factors (e.g., the genotype) and diet affect TMA production, and the colonization of these microbes and the reversal of dysbiosis as a therapy for these diseases.This work was supported by the Ministry of Science, Innovation and Universities (PSI2017-83893-R to J.L.A.) and the Ministry of Economy and Business (PSI2015-73111-EXP to J.L.A., PSI2017-90806-REDT to J.L.A. and AGL2017-83653R to M.G.) (Spain). S.A. was the recipient of a postdoctoral Juan de la Cierva Contract (Ministry of Science, Innovation and Universities, Ref. IJCI-2017-32156).Peer reviewe

VP2 potentiates the proteccion induced by VP6 against the rotavirus infection in a DNA vaccine model

Viruses like particles (VLPs) composed of VP2/VP6 are very effective in inducing protection against the rotavirus infection in animal models. Individually, VP6 also can induce protection against the infection; however, there is no information about the immunogenicity of VP2. The aim of this work was to evaluate the efficacy of DNA vaccines that codify for VP2 and VP6 alone or combined to induce protection against the rotavirus infection. Murine rotavirus VP2 and VP6 genes were cloned into the pCDNA-3 vector. Adult BALB/c mice were inoculated 3 times by intramuscular injections with 100 or 200 mg of pCDNA-3VP2 and pCDNA-3VP6, alone or combined. Two weeks after the last inoculation, mice were challenged with the murine rotavirus EDIM. We found that both plasmids pCDNA-3VP2 and pCDNA-3VP6 were able to induce rotavirus-specific serum antibodies, but not intestinal rotavirus-specific IgA. Only pCDNA-3VP6 at 200 mg could induce 30 % protection against the infection. Co-administration of 100 mg of pCDNA-3VP2 with 100 mg of pCDNA-3VP6 induced 35 % protection. When different ratios of pCDNA-3VP2/pCDNA-3VP6 were used, it was found that the co-administration of 10 µg pCDNA-3VP2/ 100 µg pCDNA-3VP6 gave the best result with up to 55 % protection. These results indicate that the DNA plasmid expressing VP6 is a better vaccine candidate that the one expressing VP2 but co-administration of both plasmids is a good alternative to potentiate the protection induced by VP6, probably by the formation of VLPs VP2/VP6 in vivo

SURVIVAL CAPACITY OF Arcobacter butzleri INOCULATED IN POULTRY MEAT AT TWO DIFFERENT REFRIGERATION TEMPERATURES

Arcobacter spp. are emerging enteropathogens and potential zoonotic agents that can be transmitted by food and water, being considered a public health risk. The high isolation rate of these bacteria from poultry products suggests that it may be a major source of human infections. One hallmark for differentiating the genus Arcobacter fromCampylobacter includes their growing capacity at low temperatures (15-30 °C) under aerobic conditions. However, little is known about the population density variation of these bacteria at different refrigeration temperatures. The aim of this study was to determine the survival behavior of two different Arcobacter butzleri concentrations (104 CFU/mL and 107 CFU/mL) inoculated on chicken legs and held at two different refrigeration temperatures (4 and 10 °C) throughout storage time. Results have shown that A. butzleri had growing capacity both at 4 and 10 °C. No statistical difference between the survival trends was found for both bacterial concentrations and temperatures tested. This study shows that A. butzleri is a robust species with regard to storage temperature, and represents a potential health risk for poultry meat consumers

Nuclear Physics in the Era of Quantum Computing and Quantum Machine Learning

In this paper, the application of quantum simulations and quantum machine learning to solve low-energy nuclear physics problems is explored. The use of quantum computing to deal with nuclear physics problems is, in general, in its infancy and, in particular, the use of quantum machine learning in the realm of nuclear physics at low energy is almost nonexistent. We present here three specific examples where the use of quantum computing and quantum machine learning provides, or could provide in the future, a possible computational advantage: i) the determination of the phase/shape in schematic nuclear models, ii) the calculation of the ground state energy of a nuclear shell model-type Hamiltonian and iii) the identification of particles or the determination of trajectories in nuclear physics experiments.Comment: Submitted to the special issue "Quantum Machine Learning" of the journal Advanced Quantum Technologie

La escala de sexismo ambivalente en estudiantes de dos universidades de Arequipa

In this study we analyze the psychometric properties of Ambivalent Sexism Inventory, so then value its results after the application in a simple of 434 students from two universities at Arequipa City. The psychometric values indicate that the items are homogeneous and the test count with construct validity and reliability (α= 0.742). The results, also note significant differences between men and women, being the males who are more sexist than females, specially, in hostile sexism, benevolent paternalism sexism, and gender diff erentiation benevolent sexism. About the university, those students who come from public university are more sexism, so as those who study engineering.En este estudio se analizaron las propiedades psicométricas del Inventario de Sexismo Ambivalente, para luego valorar sus resultados, tras ser aplicado a una muestra de 434 estudiantes universitarios de dos universidades de la ciudad de Arequipa. Los valores psicométricos indican que los ítems son homogéneos y que cuenta con validez de constructo y confiabilidad adecuados (α= 0.742). Se reportaron diferencias significativas entre varones y mujeres, siendo los varones más sexistas que aquellas, sobre todo en el sexismo hostil y benévolo paternalista y diferencia de género. En cuanto a la universidad de procedencia, los estudiantes de la universidad pública fueron más sexistas, así como quienes estudian carreras de ingenierías

Publication of RDF streams with Ztreamy

Proceedings of ESWC 2014 Satellite Events, Anissaras, Crete, Greece, May 25–29, 2014There is currently an interest in the Semantic Web community for the development of tools and techniques to process RDF streams. Implementing an effective RDF stream processing system requires to address several aspects including stream generation, querying, reasoning, etc. In this work we focus on one of them: the distribution of RDF streams through the Web. In order to address this issue, we have developed Ztreamy, a scalable middleware which allows to publish and consume RDF streams through HTTP. The goal of this demo is to show the functionality of Ztreamy in two different scenarios with actual, heterogeneous streaming data.This work has been partially funded by the Spanish Government through the project HERMES-SMARTDRIVER (TIN2013-46801-C4-2-R)

Exercises and Dry Needling for Subacromial Pain Syndrome: a Randomized Parallel- Group Trial.

This randomized clinical trial investigated the effectiveness of exercise vs. exercise plus trigger point dry needling (TrP-DN) in subacromial pain syndrome. A randomized parallel-group trial, with 1-year follow-up was conducted. Fifty subjects with subacromial pain syndrome were randomly allocated to receive exercise alone or exercise +TrP-DN. Participants in both groups were asked to perform an exercise program of the rotator cuff muscles twice daily for 5 weeks. Further, patients allocated to the exercise +TrP-DN group also received dry needling to active TrPs in the muscles reproducing shoulder symptoms during the 2nd and 4th sessions. The primary outcome was pain-related disability assessed with the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire. Secondary outcomes included mean current pain and the worst pain experienced in the shoulder during the previous week. They were assessed at baseline, one week, and 3, 6, and 12 months after the end of treatment. Analysis was by intention to treat with mixed ANCOVA adjusted for baseline outcomes. At 12 months, 47 (94%) patients completed follow-up. Statistically larger improvements (all, P<0.01) in shoulder disability was found for the exercise +TrP-DN group at all follow up periods [post: Δ -20.6 (-23.8 to -17.4); 3 months: Δ -23.2 (-28.3 to -18.1); 6 months: Δ -23.6 (-28.9 to -18.3); 12 months: Δ -13.9 (-17.5 to -10.3). Both groups exhibited similar improvements in shoulder pain outcomes at all follow-up periods. The inclusion of TrP-DN to an exercise program was effective for improving disability in subacromial pain syndrome. No greater improvements in shoulder pain were observed.pre-print2407 K