Single nucleotide polymorphisms in the mitochondrial displacement loop and outcome of esophageal squamous cell carcinoma

<p>Abstract</p> <p>Backgroud</p> <p>Accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) has been described for different types of cancers and might be associated with cancer risk and disease outcome. We used a population-based series of esophageal squamous cell carcinoma (ESCC) patients for investigating the prediction power of SNPs in mitochondrial D-loop.</p> <p>Methods</p> <p>The D-loop region of mtDNA was sequenced for 60 ESCC patients recorded in the Fourth Hospital of Hebei Medical University between 2003 and 2004. The 5 year survival curve were calculated with the Kaplan-Meier method and compared by the log-rank test at each SNP site, a multivariate survival analysis was also performed with the Cox proportional hazards method.</p> <p>Results</p> <p>The SNP sites of nucleotides 16274G/A, 16278C/T and 16399A/G were identified for prediction of post-operational survival by the log-rank test. In an overall multivariate analysis, the 16278 and 16399 alleles were identified as independent predictors of ESCC outcome. The length of survival of patients with the minor allele 16278T genotype was significantly shorter than that of patients with 16278C at the 16278 site (relative risk, 3.001; 95% CI, 1.029 - 8.756; <it>p </it>= 0.044). The length of survival of patients with the minor allele 16399G genotype was significantly shorter than that of patients with the more frequent allele 16399A at the 16399 site in ESCC patients (relative risk, 3.483; 95% CI, 1.068 - 11.359; <it>p </it>= 0.039).</p> <p>Conclusion</p> <p>Genetic polymorphisms in the D-loop are independent prognostic markers for patients with ESCC. Accordingly, the analysis of genetic polymorphisms in the mitochondrial D-loop can help identify patient subgroups at high risk of a poor disease outcome.</p

Corrigendum to: The TianQin project: current progress on science and technology

In the originally published version, this manuscript included an error related to indicating the corresponding author within the author list. This has now been corrected online to reflect the fact that author Jun Luo is the corresponding author of the article

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Neural Adaptive Funnel Dynamic Surface Control with Disturbance-Observer for the PMSM with Time Delays

This paper suggests an adaptive funnel dynamic surface control method with a disturbance observer for the permanent magnet synchronous motor with time delays. An improved prescribed performance function is integrated with a modified funnel variable at the beginning of the controller design to coordinate the permanent magnet synchronous motor with the output constrained into an unconstrained one, which has a faster convergence rate than ordinary barrier Lyapunov functions. Then, the specific controller is devised by the dynamic surface control technique with first-order filters to the unconstrained system. Therein, a disturbance-observer and the radial basis function neural networks are introduced to estimate unmatched disturbances and multiple unknown nonlinearities, respectively. Several Lyapunov-Krasovskii functionals are constructed to make up for time delays, enhancing control performance. The first-order filters are implemented to overcome the &ldquo;complexity explosion&rdquo; caused by general backstepping methods. Additionally, the boundedness and binding ranges of all the signals are ensured through the detailed stability analysis. Ultimately, simulation results and comparison experiments confirm the superiority of the controller designed in this paper

An Enhanced Differential Evolution Algorithm with Bernstein Operator and Refracted Oppositional-Mutual Learning Strategy

Numerical optimization has been a popular research topic within various engineering applications, where differential evolution (DE) is one of the most extensively applied methods. However, it is difficult to choose appropriate control parameters and to avoid falling into local optimum and poor convergence when handling complex numerical optimization problems. To handle these problems, an improved DE (BROMLDE) with the Bernstein operator and refracted oppositional-mutual learning (ROML) is proposed, which can reduce parameter selection, converge faster, and avoid trapping in local optimum. Firstly, a new ROML strategy integrates mutual learning (ML) and refractive oppositional learning (ROL), achieving stochastic switching between ROL and ML during the population initialization and generation jumping period to balance exploration and exploitation. Meanwhile, a dynamic adjustment factor is constructed to improve the ability of the algorithm to jump out of the local optimum. Secondly, a Bernstein operator, which has no parameters setting and intrinsic parameters tuning phase, is introduced to improve convergence performance. Finally, the performance of BROMLDE is evaluated by 10 bound-constrained benchmark functions from CEC 2019 and CEC 2020, respectively. Two engineering optimization problems are utilized simultaneously. The comparative experimental results show that BROMLDE has higher global optimization capability and convergence speed on most functions and engineering problems

Quantifying Liver Stagnation Spleen Deficiency Pattern for Diarrhea Predominate Irritable Bowel Syndromes Using Multidimensional Analysis Methods

Objective. This study aims to offer a new approach for quantifying severity of traditional Chinese medicine pattern with multidimensional analysis methods. Methods. A scale and theoretical models were constructed based on the definition of liver stagnation spleen deficiency pattern. Clinical data of 344 IBS-D patients from a cross-sectional study was used for feature validation of the model. Confirmatory factor analysis was used for evaluating the models. Also, multidimensional item response model was used for assessing multidimensional psychometric properties of the scale. Results. Detecting two latent traits, the Cronbach’s alpha of the 9-item scale was 0.745. Multidimensional model was evaluated with significant goodness of fit indices while the unidimensional model was rejected. The multidimensional item response model showed all the items had adequate discrimination. Parameters presented adequate explanation regarding mental syndromes having high factor loading on the liver stagnation factor and abdominal discomfort syndromes highly related to the spleen deficiency factor. Test information function showed that scale demonstrated the highest discrimination power among patients with moderate to high level of severity. Conclusions. The application of the multidimensional analysis methods on the basis of theoretical model construction provides a useful and rational approach for quantifying the severity of traditional Chinese medicine patterns

Deep reinforcement learning task scheduling method based on server real-time performance

Server load levels affect the performance of cloud task execution, which is rooted in the impact of server performance on cloud task execution. Traditional cloud task scheduling methods usually only consider server load without fully considering the server’s real-time load-performance mapping relationship, resulting in the inability to evaluate the server’s real-time processing capability accurately. This deficiency directly affects the efficiency, performance, and user experience of cloud task scheduling. Firstly, we construct a performance platform model to monitor server real-time load and performance status information in response to the above problems. In addition, we propose a new deep reinforcement learning task scheduling method based on server real-time performance (SRP-DRL). This method introduces a real-time performance-aware strategy and adds status information about the real-time impact of task load on server performance on top of considering server load. It enhances the perception capability of the deep reinforcement learning (DRL) model in cloud scheduling environments and improves the server’s load-balancing ability under latency constraints. Experimental results indicate that the SRP-DRL method has better overall performance regarding task average response time, success rate, and server average load variance compared to Random, Round-Robin, Earliest Idle Time First (EITF), and Best Fit (BEST-FIT) task scheduling methods. In particular, the SRP-DRL is highly effective in reducing server average load variance when numerous tasks arrive within a unit of time, ultimately optimizing the performance of the cloud system

Multi-Strategy-Improved Growth Optimizer and Its Applications

The growth optimizer (GO) is a novel metaheuristic algorithm designed to tackle complex optimization problems. Despite its advantages of simplicity and high efficiency, GO often encounters localized stagnation when dealing with discretized, high-dimensional, and multi-constraint problems. To address these issues, this paper proposes an enhanced version of GO called CODGBGO. This algorithm incorporates three strategies to enhance its performance. Firstly, the Circle-OBL initialization strategy is employed to enhance the quality of the initial population. Secondly, an exploration strategy is implemented to improve population diversity and the algorithm’s ability to escape local optimum traps. Finally, the exploitation strategy is utilized to enhance the convergence speed and accuracy of the algorithm. To validate the performance of CODGBGO, it is applied to solve the CEC2017, CEC2020, 18 feature selection problems, and 4 real engineering optimization problems. The experiments demonstrate that the novel CODGBGO algorithm effectively addresses the challenges posed by complex optimization problems, offering a promising approach