Re‐Imagining Inclusion Through the Lens of Disabled Childhoods

The purpose of this article is to contribute new insights to critical disability and disabled children’s childhood studies that center on the valuing of disabled children’s lives—a guiding purpose in the disability justice movement. We use published findings from the Inclusive Early Childhood Service System project, a longitudinal, institutional ethnography of the ways that families and children are organized around categories of disability, which show social inclusions and exclusions before and during the pandemic. These findings illuminate: (a) institutional flexibility for the purpose of social inclusion and isolation during the pandemic as a result of institutional organization; (b) the impact of institutional decisions around closures, remote programs, and support on families’ choices and self‐determination; and (3) the ways safety is differently applied and rationalized for disabled children allowing institutions to exclude disabled children and families. We use critical disability studies and disabled children’s childhood studies to interpret these findings and position the valuing of disabled children’s lives with a call for disability justice actions

Catalyst: Festival of Creativity - Make Good Livelihoods

Make Good Livelihoods Sat 18th & Sun 19th June Make Good Livelihoods is a free public weekend of activities, demonstrations and talks to celebrate the people who make their livelihood from craftsmanship in Sheffield, and inspire others to do the same. Young people will be offered a rare opportunity to see the work of some of Sheffield’s most exciting craftspeople, find out how they became makers, and have a go at making something themselves. The Millennium Gallery will come alive as metalworkers, wood-workers, textile artists, sculptors, graphic designers, printmakers and fashion designers demonstrate the skills, knowledge and spirit required to create beautiful and useful things. Hear how practitioners at Sheffield Hallam University and other craftspeople make a satisfying living, and how you can take steps towards it. Students from Hallam University, Freeman College, UTC and Sheffield schools will be on hand to share their making skills too. Sheffield Institute of Arts opens the doors of its stunning new home in the former Head Post Office, where you can try your hand at digital making techniques. Portland Works will run activities ranging from traditional forging to high-tech creation with their Hackers and Makers. Open access media lab Access Space will offer bespoke workshops for people to create works using digital embroidery and laser-cutting. All are welcome to this weekend of activity to reveal how Sheffield’s rich heritage of craftsmanship, so admired by renowned Victorian thinker John Ruskin, is alive, constantly evolving, and providing good livelihoods for people today. The Make Good Livelihoods weekend draws inspiration from the exhibition In the Making: Ruskin, Creativity and Craftsmanship, at the Millennium Gallery until 5th June. Make Good Livelihoods is a collaboration between SHU, the Guild of St George, which owns and support the Ruskin Collection, Museums Sheffield, Portland Works and Access Space. It is part of a wider programme of Ruskin in Sheffield events

Detection of submicron- and nanoplastics spiked in environmental fresh- and saltwater with Raman spectroscopy

Detection of small plastic particles in environmental water samples has been a topic of increasing interest in recent years. A multitude of techniques, such as variants of Raman spectroscopy, have been employed to facilitate their analysis in such complex sample matrices. However, these studies are often conducted for a limited number of plastic types in matrices with relatively little additional materials. Thus, much remains unknown about what parameters influence the detection limits of Raman spectroscopy for more environmentally relevant samples. To address this, this study utilizes Raman spectroscopy to detect six plastic particle types; 161 and 33 nm polystyrene, < 450 nm and 36 nm poly(ethylene terephthalate), 121 nm polypropylene, and 126 nm polyethylene; spiked into artificial saltwater, artificial freshwater, North Sea, Thames River, and Elbe River water. Overall, factors such as plastic particle properties, water matrix composition, and experimental setup were shown to influence the final limits of detection

Assessment of Possibility and Impact of Rapid Climate Change in the Arctic

Sea ice decline is iconic of climate change in the Arctic. Sea ice reductions represent the integrated changes which are taking place in both the ocean and atmosphere. Arctic surface temperature is also warming. The presence of sea ice determines the accessibility of the Arctic Ocean and its presence can also affect European and global climate

Zhongguo-tianran-yaowu : = Chinese journal of natural medicines

Receptor-interacting protein kinase (RIPK) 1 functions as a key mediator of tissue homeostasis via formation of Caspase-8 activating ripoptosome complexes, positively and negatively regulating apoptosis, necroptosis, and inflammation. Here, we report an unanticipated cell-death-and inflammation- independent function of RIPK1 and Caspase-8, promoting faithful chromosome alignment in mitosis and thereby ensuring genome stability. We find that ripoptosome complexes progressively form as cells enter mitosis, peaking at metaphase and disassembling as cells exit mitosis. Genetic deletion and mitosis-specific inhibition of Ripk1 or Caspase-8 results in chromosome alignment defects independently of MLKL. We found that Polo-like kinase 1 (PLK1) is recruited into mitotic ripoptosomes, where PLK1's activity is controlled via RIPK1-dependent recruitment and Caspase-8-mediated cleavage. A fine balance of ripoptosome assembly is required as deregulated ripoptosome activity modulates PLK1-dependent phosphorylation of downstream effectors, such as BUBR1. Our data suggest that ripoptosome-mediated regulation of PLK1 contributes to faithful chromosome segregation during mitosis

Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer

Gastrointestinal epithelial cells provide a selective barrier that segregates the host immune system from luminal microorganisms, thereby contributing directly to the regulation of homeostasis. We have shown that from early embryonic development Bcl-G, a Bcl-2 protein family member with unknown function, was highly expressed in gastrointestinal epithelial cells. While Bcl-G was dispensable for normal growth and development in mice, the loss of Bcl-G resulted in accelerated progression of colitis-associated cancer. A label-free quantitative proteomics approach revealed that Bcl-G may contribute to the stability of a mucin network, which when disrupted, is linked to colon tumorigenesis. Consistent with this, we observed a significant reduction in Bcl-G expression in human colorectal tumors. Our study identifies an unappreciated role for Bcl-G in colon cancer