Veränderte Machtverteilung im Ministerrat nach der EU-Erweiterung

Gemessen an ihrer Bevölkerungszahl sind die kleinen Staaten gegenwärtig im Ministerrat der EU bei Abstimmungen übervertreten. Welche Auswirkungen ergeben sich hieraus für die Machtverteilung im Ministerrat? Wie ändern sich die Verhältnisse durch die Erweiterung der Europäische Union? --

Représentation du langage et modèles d'évolution linguistique : la grammaticalisation comme perspective

International audienceThough numerous numerical studies have investigated language change, grammaticalization and diachronic phenomena of language renewal have been left aside, or so it seems. We argue that previous models, dedicated to other purposes, make representational choices that cannot easily account for this type of phenomenon. In this paper we propose a new framework , aiming to depict linguistic renewal through numerical simulations. We illustrate it with a specific implementation which brings to light the phenomenon of semantic bleaching.Bien que le changement linguistique ait fait l'objet de nombreuses recherches numé-riques, les phénomènes diachroniques de renouvellement linguistique et plus spécifiquement la grammaticalisation ont été, semble-t-il, laissés de côté. Motivés par d'autres perspectives, les différents modèles s'appuient sur des représentations qui, comme nous le montrons, ne per-mettent pas d'aborder efficacement la modélisation de ce type de phénomènes. Nous proposons ici un cadre de représentation visant à décrire le renouvellement linguistique et se prêtant bien à la simulation numérique. Nous l'illustrons par une implémentation particulière mettant en évidence le phénomène de javellisation sémantique

Diachronic Emergence of Zipf-like Patterns in Construction-Specific Frequency Distributions: A Quantitative Study of the Way Too Construction

Les constituants linguistiques servant à l’expression spatiale du chemin sont souvent mobilisés dans des constructions schématiques plus abstraites au terme d’un processus diachronique de constructionalisation. C’est le cas de la construction intensifiante way too en anglais, dont je retrace ici l’origine à une construction antérieure away too. Par ailleurs, l’émergence d’une construction schématique s’accompagne d’une variation de la fréquence des types, c’est-à-dire du nombre d’éléments linguistiques qu’elle reçoit comme argument. Si l’évolution de la fréquence brute lors d’une constructionalisation a depuis longtemps fait l’objet d’une perspective quantitative, ce n’est pas le cas de la fréquence des types. Je montre que la fréquence des types et la fréquence brute sont liées tout au cours de l’évolution par une organisation spécifique, régie par une loi de Zipf dont le coefficient évolue avec le temps, et qui range les différents types suivant leur fréquence de collocation dans la construction d’une manière non seulement robuste au cours du temps, mais également d’une variété d’anglais à l’autre.The linguistic constituents that come to express path are often co-opted into more abstract schematic constructions through a diachronic process known as constructionalization. This applies to the way too intensifier construction, whose origin I retrace to a former away too construction. Moreover, the emergence of a schematic construction is associated with an evolution of its type frequency (the total number of different linguistic units that fill the free slot of the construction). Although the evolution of the token frequency throughout a constructionalization process has already been studied from a quantitative perspective, the type frequency has not received such an empirical characterization. I show that the type and token frequencies are related with one another through a Zipf’s law, whose coefficient varies with time, and which sorts the different types according to their collocate frequency in a way that is robust both across time and across varieties of English

Mikroskopische und molekularbiologische Analyse des chloroplastidären Ribonukleoproteins CP29A während der Kältestressantwort in Arabidopsis thaliana

Das plastidäre Genexpressionssystem höherer Pflanzen ist hochkomplex und differiert beträchtlich von dem prokaryotischer Vorfahren. Jeder einzelne Schritt der RNA-Prozessierung und Translation ist abhängig von nukleär kodierten, posttranslational in den Chloroplasten importierten Proteinen, insbesondere RNA-Bindeproteinen, wie den chloroplastidären Ribonukleoproteinen (cpRNP). Ein wichtiger und im Fokus dieser Arbeit stehender Vertreter ist CP29A, welcher ein breites Bindespektrum aufweist und in vivo mit einer Vielzahl von Transkripten interagiert. Frühere Studien belegen dennoch, dass ein Knockout von CP29A unter Standardkultivierungsbedingungen nicht in einem makroskopisch vom Wildtyp differierenden Phänotyp resultiert. Unter Kältestress hingegen ist CP29A für die Entwicklung photosynthetisch aktiver Chloroplasten essenziell. Zur tiefergehenden Charakterisierung der molekularen Funktion von CP29A wurde in der vorliegenden Arbeit eine genomweite Transkriptomanalyse der cp29a-Mutante durchgeführt. Es konnte erstmals gezeigt werden, dass CP29A bereits unter Standardkultivierungsbedingungen das Spleißen vieler plastidärer Introns unterstützt. Kälteinduziert weist das phänotypisch auffällige Gewebe der cp29a-Mutante eine globale Beeinträchtigung der Genexpression sowie massive Defekte der plastidären mRNA-Prozessierung auf. Da die Funktionalität von Proteinen substanziell von ihrer Lokalisation abhängig ist, wurden antikörperbasierte mikroskopische Lokalisationsstudien durchgeführt. Diese dokumentieren, dass CP29A kältestressinduziert zu dynamischen Granula lokalisiert, welche separiert von den plastidären Nukleoiden vorliegen und mit einem häufig in stressinduzierten Granula detektierten Protein kolokalisieren.The plastid gene expression system in higher plants is highly complex and differs significantly from the gene expression system of the prokaryotic ancestors. Each individual step of RNA-processing and translation is dependent on nuclear-encoded RNA-binding proteins, such as chloroplast ribonucleoproteins (cpRNP), which are imported post-translationally into the chloroplast. An important representative is CP29A, which has a broad binding spectrum and interacts with a large number of transcripts in vivo. Earlier studies show that, while a knockout of CP29A under standard-cultivation-conditions does not result in a macroscopically different phenotype, under cold stress conditions CP29A is essential for the development of photosynthetically active chloroplasts. For a more detailed characterization of the molecular function of CP29A, a genome-wide transcriptome analysis of the cp29a mutant was carried out. It could be shown for the first time that CP29A already supports the splicing of many chloroplast introns under standard-cultivation-conditions. Cold-induced the phenotypically noticeable mutant tissue shows a global impairment of gene expression and massive defects in plastid mRNA processing. Since the functionality of proteins is substantially dependent on their localization, antibody-based microscopic localization studies were carried out. They reveal that cold stress-induced CP29A localizes to dynamic granules, which are separate from the plastid nucleoids and colocalize with a protein commonly detected in stress-induced granules

Systematic review of the agreement of tonometers with goldmann applanation tonometry

This review was part of the Surveillance for Ocular Hypertension study funded by the UK National Institute for Health Research Health Technology Assessment Programme (Project No. 07/46/02). J.C. held a Medical Research Council UK fellowship (G0601938). AA-B was a grantholder on an AstraZeneca (London, UK) funded study of a new medication for glaucoma. The Health Services Research Unit receives core funding from the Chief Scientist Office of the Scottish Government Health Directorates. Views and opinions expressed are those of the authors and do not necessarily reflect those of the Chief Scientist Office, National Institute for Health Research Health Technology Assessment Programme, or the Department of Health. None of the funders had a role in the design or conduct of this researchPeer reviewedPostprin

Classical Limit of Demagnetization in a Field Gradient

We calculate the rate of decrease of the expectation value of the transverse component of spin for spin-1/2 particles in a magnetic field with a spatial gradient, to determine the conditions under which a previous classical description is valid. A density matrix treatment is required for two reasons. The first arises because the particles initially are not in a pure state due to thermal motion. The second reason is that each particle interacts with the magnetic field and the other particles, with the latter taken to be via a 2-body central force. The equations for the 1-body Wigner distribution functions are written in a general manner, and the places where quantum mechanical effects can play a role are identified. One that may not have been considered previously concerns the momentum associated with the magnetic field gradient, which is proportional to the time integral of the gradient. Its relative magnitude compared with the important momenta in the problem is a significant parameter, and if their ratio is not small some non-classical effects contribute to the solution. Assuming the field gradient is sufficiently small, and a number of other inequalities are satisfied involving the mean wavelength, range of the force, and the mean separation between particles, we solve the integro- partial differential equations for the Wigner functions to second order in the strength of the gradient. When the same reasoning is applied to a different problem with no field gradient, but having instead a gradient to the z-component of polarization, the connection with the diffusion coefficient is established, and we find agreement with the classical result for the rate of decrease of the transverse component of magnetization.Comment: 22 pages, no figure

Risk factors for severe bleeding complications in glaucoma surgery and the role of antiplatelet or anticoagulant agents

PURPOSE: To evaluate the influences and risk factors for severe bleeding complications during glaucoma surgery, and to investigate the role of antiplatelet (AP) and anticoagulant (AC) agents. METHODS: This prospective study enrolled patients undergoing trabeculectomy, trabeculotomy (with Trabectome® or Kahook Dual Blade®), viscocanaloplasty and Ahmed or Baerveldt implants. Bleeding severity was graded on an ordinal scale ranging from 0 to 5. Immediately after surgery and one day later, the incidence and severity of bleeding events was documented on a standardized form. A grade ≥3 was defined as severe bleeding. The influence of known systemic disorders, the type of anesthesia, surgical procedure, intraoperative blood pressure, and the use of or change in AP or AC agents on intraoperative bleeding were analyzed. RESULTS: Data from 89 eyes undergoing glaucoma procedures were included (age 71.3y ± 10.5). We observed severe intraoperative bleeding in 8 eyes (9%) and found that concomitant diseases such as the history of a deep vein thrombosis or peripheral arterial occlusive disease, and the type of surgical procedure (trabeculectomy and viscocanaloplasty) were significantly associated with severe bleeding events. By contrast, the use of AP/ AC agents had no significant influence on severe intraoperative bleeding events. CONCLUSION: According to the results of our study cohort, glaucoma procedures entailing scleral manipulations (trabeculectomy and viscocanaloplasty) and concomitant diseases such as the history of a deep vein thrombosis or peripheral arterial occlusive disease influence the risk of severe intraoperative bleeding events, we detected no increased risk related to concomitant antiplatelet and/ or anticoagulant medication use

Description of recent large-qq neutron inclusive scattering data from liquid 4^4He

We report dynamical calculations for large-$q$ structure functions of liquid $^4$He at $T$=1.6 and 2.3 K and compare those with recent MARI data. We extend those calculations far beyond the experimental range q\le 29\Ain in order to study the approach of the response to its asymptotic limit for a system with interactions having a strong short-range repulsion. We find only small deviations from theoretical $1/q$ behavior, valid for smooth $V$. We repeat an extraction by Glyde et al of cumulant coefficients from data. We argue that fits determine the single atom momentum distribution, but express doubt as to the extraction of meaningful Final State Interaction parameters.Comment: 37 pages, 13 postscript fig

An analysis of French borrowings at the hypernymic and hyponymic levels of Middle English

This paper analyses a large dataset of Middle English vocabulary from nine domains which has been arranged into a semantic hierarchy. It focuses on the distribution of French-origin borrowings at various levels of technicality and at various levels of co-hyponymic density (i.e. the number of words per sense). Overall, results show that French loanwords are concentrated in higher proportions at the hypernymic (or more general) level rather than at the hyponymic (or more technical) level. These findings run counter to the orthodox view that borrowings are used to fill lexical gaps for new technical terms in a semantic field

Intravitreal ranibizumab versus isovolemic hemodilution in the treatment of macular edema secondary to central retinal vein occlusion: Twelve-month results of a prospective, randomized, multicenter trial

PURPOSE This is a prospective, randomized, multicenter, investigator-initiated trial to evaluate the 12-month effectiveness of isovolemic hemodilution (IH) with prompt versus deferred intravitreal injections (IVI) of ranibizumab 0.5 mg for the treatment of macular edema secondary to early central retinal vein occlusion (CRVO). METHODS Eyes with macular edema due to CRVO having occurred not more than 8 weeks previously received either monthly ranibizumab IVI in combination with IH (group I, n = 28) or IH alone (group II, n = 30). From month 2 to 12, the patients in both groups could be treated with monthly intravitreal ranibizumab. The main outcome variables were gain of visual acuity and the course of central retinal thickness as measured with optical coherence tomography. RESULTS At 12 months, eyes in group I on average gained +28.1 (±19.3) letters compared to +25.2 (±20.9) letters in group II (p = 0.326). This result was achieved with significantly fewer injections in group II. Additionally, 30% of the eyes in group II did not need ranibizumab IVI during the 12 months of the trial. CONCLUSION Ranibizumab IVI in addition to IH proved to be highly effective in increasing visual acuity and reducing macular edema secondary to CRVO. Initial IH in early CRVO may be a first treatment option in patients anxious about IVI