Invasive disseminated aspergillosis with multiple intracranial localizations associated to chronic granulomatous disease: Case report

L’apergillose invasive disséminée avec localisation cérébrale est une pathologie rare. Elle survient le plus souvent dans le cadre d’une immunodépression. Le type d’aspergillus responsable de ce tableau est le plus souvent l’Aspergillus fumigatus ; il peut s’agir exceptionnellement d’un Aspergillus nidulans. La prise en charge des lésions cérébrales entrant dans le cadre de cette pathologie comprend la chirurgie et le traitement  médical. Le pronostic est très sombre. Nous rapportons le cas d’une fillette âgée de 8 ans, ayant dans les antécédents une histoire d’infections répétées, qui a présenté une aspergillose invasive disséminée avec localisations cérébrales multiples. Cette patiente a été traitée par chirurgie et traitement médical. Elle est décédée d’une hépatite B au bout de 40 mois

A regionally based precision medicine implementation initiative in North Africa:The PerMediNA consortium

International audiencePrecision Medicine is being increasingly used in the developed world to improve health care. While several Precision Medicine (PM) initiatives have been launched worldwide, their implementations have proven to be more challenging particularly in low- and middle-income countries. To address this issue, the “Personalized Medicine in North Africa” initiative (PerMediNA) was launched in three North African countries namely Tunisia, Algeria and Morocco. PerMediNA is coordinated by Institut Pasteur de Tunis together with the French Ministry for Europe and Foreign Affairs, with the support of Institut Pasteur in France. The project is carried out along with Institut Pasteur d’Algérie and Institut Pasteur du Maroc in collaboration with national and international leading institutions in the field of PM including Institut Gustave Roussy in Paris. PerMediNA aims to assess the readiness level of PM implementation in North Africa, to strengthen PM infrastructure, to provide workforce training, to generate genomic data on North African populations, to implement cost effective, affordable and sustainable genetic testing for cancer patients and to inform policy makers on how to translate research knowledge into health products and services. Gender equity and involvement of young scientists in this implementation process are other key goals of the PerMediNA project.In this paper, we are describing PerMediNA as the first PM implementation initiative in North Africa. Such initiatives contribute significantly in shortening existing health disparities and inequities between developed and developing countries and accelerate access to innovative treatments for global health