The interaction between transpolar arcs and cusp spots

Transpolar arcs and cusp spots are both auroral phenomena which occur when the interplanetary magnetic field is northward. Transpolar arcs are associated with magnetic reconnection in the magnetotail, which closes magnetic flux and results in a "wedge" of closed flux which remains trapped, embedded in the magnetotail lobe. The cusp spot is an indicator of lobe reconnection at the high-latitude magnetopause; in its simplest case, lobe reconnection redistributes open flux without resulting in any net change in the open flux content of the magnetosphere. We present observations of the two phenomena interacting--i.e., a transpolar arc intersecting a cusp spot during part of its lifetime. The significance of this observation is that lobe reconnection can have the effect of opening closed magnetotail flux. We argue that such events should not be rare

Flux ropes in the Hermean magnetotail: Distribution, properties, and formation

An automated method was applied to identify magnetotail flux rope encounters in MESSENGER (MErcury Surface, Space ENvironment, GEochemistry, and Ranging) magnetometer data. The method identified significant deflections of the northâ south component of the magnetic field coincident with enhancements in the total field or dawnâ dusk component. Two hundred fortyâ eight flux ropes are identified that possess wellâ defined minimum variance analysis (MVA) coordinate systems, with clear rotations of the field. Approximately 30% can be well approximated by the cylindrically symmetric, linearly forceâ free model. Flux ropes are most common moving planetward, in the postmidnight sector. Observations are intermittent, with the majority (61%) of plasma sheet passages yielding no flux ropes; however, the peak rate of flux ropes during a reconnection episode is â ¼5 minâ 1. Overall, the peak postmidnight rate is â ¼0.25 minâ 1. Only 25% of flux ropes are observed in isolation. The radius of flux ropes is comparable to the ion inertial length within Mercury’s magnetotail plasma sheet. No clear statistical separation is observed between tailward and planetward moving flux ropes, suggesting the nearâ Mercury neutral line (NMNL) is highly variable. Flux ropes are more likely to be observed if the preceding lobe field is enhanced over background levels. A very weak correlation is observed between the flux rope core field and the preceding lobe field orientation; a stronger relationship is found with the orientation of the field within the plasma sheet. The core field strength measured is â ¼6 times stronger than the local dawnâ dusk plasma sheet magnetic field.Key PointsTwo hundred fortyâ eight flux ropes identified in Mercury’s magnetotail (74 cylindrical and linearly forceâ free)Flux ropes most commonly observed by MESSENGER postmidnight, moving planetwardFlux ropes observed intermittently, but most often when the preceding lobe field is enhancedPeer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138858/1/jgra53697_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138858/2/jgra53697.pd

Parental social contact in the work place and the risk of childhood acute lymphoblastic leukaemia

To study the possible relation between parental social contact through occupation, a marker for a child's risk of infection, and childhood acute lymphoblastic leukaemia (ALL), the parents of 294 children with ALL aged 0–14.9 years and 376 matched controls were interviewed about their jobs after their child's birth up to the age of 3 years. Job titles were assigned to a level of social contact, and an index of occupational social contact months was created using the level and the job duration. Positive interactions between this index and rural residence associated with an increased risk of childhood ALL and common ALL (c-ALL) were observed (interaction P-value=0.02 for both, using tertiles of contact months; interaction P-value=0.05 and 0.02 for ALL and c-ALL, respectively, using continuous contact months); such findings were not observed when job durations were ignored. Our data suggest that duration of parental occupation may be important when examining the association between parental social contact in the workplace and childhood leukaemia

Genetic influence on scar height and pliability after burn injury in individuals of European ancestry: A prospective cohort study

After similar extent of injury there is considerable variability in scarring between individuals, in part due to genetic factors. This study aimed to identify genetic variants associated with scar height and pliability after burn injury. An exome-wide array association study and gene pathway analysis were performed on a prospective cohort of 665 patients treated for burn injury. Outcomes were scar height (SH) and scar pliability (SP) sub-scores of the modified Vancouver Scar Scale (mVSS). DNA was genotyped using the Infinium® HumanCoreExome-24 BeadChip. Associations between genetic variants (single nucleotide polymorphisms) and SH and SP were estimated using an additive genetic model adjusting for age, sex, number of surgical procedures and % total body surface area of burn in subjects of European ancestry. No individual genetic variants achieved the cut-off threshold of significance. Gene regions were analysed for spatially correlated single nucleotide polymorphisms and significant regions identified using comb-p software. This gene list was subject to gene pathway analysis to find which biological process terms were over-represented. Using this approach biological processes related to the nervous system and cell adhesion were the predominant gene pathways associated with both SH and SP. This study suggests genes associated with innervation may be important in scar fibrosis. Further studies using similar and larger datasets will be essential to validate these findings

Motion of flux transfer events: a test of the Cooling model

The simple model of reconnected field line motion developed by Cooling et al. (2001) has been used in several recent case studies to explain the motion of flux transfer events across the magnetopause. We examine 213 FTEs observed by all four Cluster spacecraft under a variety of IMF conditions between November 2002 and June 2003, when the spacecraft tetrahedron separation was ~5000 km. Observed velocities were calculated from multi-spacecraft timing analysis, and compared with the velocities predicted by the Cooling model in order to check the validity of the model. After excluding three categories of FTEs (events with poorly defined velocities, a significant velocity component out of the magnetopause surface, or a scale size of less than 5000 km), we were left with a sample of 118 events. 78% of these events were consistent in both direction of motion and speed with one of the two model de Hoffmann-Teller (dHT) velocities calculated from the Cooling model (to within 30° and a factor of two in the speed). We also examined the plasma signatures of several magnetosheath FTEs; the electron signatures confirm the hemisphere of connection indicated by the model in most cases. This indicates that although the model is a simple one, it is a useful tool for identifying the source regions of FTEs

Solar Wind—Magnetosphere Coupling During Radial Interplanetary Magnetic Field Conditions: Simultaneous Multi-Point Observations

S. Toledo-Redondo and J. Fornieles acknowledge support of the Ministry of Economy and Competitiveness (MINECO) of Spain (grant FIS2017-90102-R) and of Ministry of Science and Innovation (grant PID2020-112805GA-I00). Research at IRAP was supported by CNRS, CNES, and the University of Toulouse. We acknowledge support of the ISSI teams MMS and Cluster observations of magnetic reconnection and Cold plasma of ionospheric in the Earth's magnetosphere, and of the ESAC Science faculty.In-situ spacecraft missions are powerful assets to study processes that occur in space plasmas. One of their main limitations, however, is extrapolating such local measurements to the global scales of the system. To overcome this problem at least partially, multi-point measurements can be used. There are several multi-spacecraft missions currently operating in the Earth's magnetosphere, and the simultaneous use of the data collected by them provides new insights into the large-scale properties and evolution of magnetospheric plasma processes. In this work, we focus on studying the Earth's magnetopause (MP) using a conjunction between the Magnetospheric Multiscale and Cluster fleets, when both missions skimmed the MP for several hours at distant locations during radial interplanetary magnetic field (IMF) conditions. The observed MP positions as a function of the evolving solar wind conditions are compared to model predictions of the MP. We observe an inflation of the magnetosphere (similar to 0.7 R-E), consistent with magnetosheath pressure decrease during radial IMF conditions, which is less pronounced on the flank (<0.2 R-E). There is observational evidence of magnetic reconnection in the subsolar region for the whole encounter, and in the dusk flank for the last portion of the encounter, suggesting that reconnection was extending more than 15 R-E. However, reconnection jets were not always observed, suggesting that reconnection was patchy, intermittent or both. Shear flows reduce the reconnection rate up to similar to 30% in the dusk flank according to predictions, and the plasma beta enhancement in the magnetosheath during radial IMF favors reconnection suppression by the diamagnetic drift.Ministry of Economy and Competitiveness (MINECO) of Spain FIS2017-90102-RSpanish Government PID2020-112805GA-I00Centre National de la Recherche Scientifique (CNRS)European CommissionCentre National D'etudes SpatialesUniversity of ToulouseESAC Science facult

Relationship Difficulties Among U.K. Military Personnel: Impact of Sociodemographic, Military, and Deployment-Related Factors

© 2015, Taylor & Francis Group, LLC. Military work, especially operational deployments, may impact the romantic relationships of military personnel. Using a subsample of 7,581 participants from a cohort study of U.K. military personnel (data collected between 2007 and 2009), the prevalence of relationship difficulties and associations with sociodemographic, military-, and deployment-related characteristics was examined. Most participants did not report experiencing relationship difficulties. Adjusted regression analyses indicate that childhood adversity, limited support for and from partners, being in unmarried relationships, financial problems, deploying for more than 13 months in 3 years, and work being above trade, ability, and experience were key factors associated with relationship difficulties. The likelihood of U.K. military personnel experiencing relationship difficulties is increased because of personal vulnerabilities that may be exacerbated in the military context

Boundary spanning as identity work in university business engagement roles

The study explores how boundary-spanning is carried out to further community engagement in 15 universities of differing sizes/ages across the United Kingdom. Fifteen interviewees participated in a series of four semi-structured interviews, aged between 35–50 and with a first degree (with almost half with an MSc). One third were women. All managed their own teams and felt these were their base in negotiating difficult internal territory.. Here, boundary spanning is found to be synonymous with identity work, carried out to enable individuals to adapt to different internal and external conditions and requirements through processes of interaction and learning. It also suggests the strategic construction of identities to address perceived threats and insecurities - and the impacts of change, dominant organisational discourse and senior management on this process. Their job titles were not useful as identity badges to signal meaning, due to these being outside ‘what universities are for’

Burn injury leads to increased long-term susceptibility to respiratory infection in both mouse models and population studies

Background: Burn injury initiates an acute inflammatory response that subsequently drives wound repair. However, acute disruption to the immune response is also common, leading to susceptibility to sepsis and increased morbidity and mortality. Despite increased understanding of the impact of burn injury on the immune system in the acute phase, little is known about longterm consequences of burn injury on immune function. This study was established to determine whether burn injury has long-term clinical impacts on patients' immune responses. Methods: Using a population-based retrospective longitudinal study and linked hospital morbidity and death data from Western Australia, comparative rates of hospitalisation for respiratory infections in burn patients and a non-injured comparator cohort were assessed. In addition, a mouse model of non-severe burn injury was also used in which viral respiratory infection was induced at 4 weeks post-injury using a mouse modified version of the Influenza A virus (H3NN; A/mem/71-a). Results and conclusions: The burn injured cohort contained 14893 adult patients from 1980-2012 after removal of those patients with evidence of smoke inhalation or injury to the respiratory tract. During the study follow-up study a total of 2,884 and 2,625 respiratory infection hospital admissions for the burn and uninjured cohorts, respectively, were identified. After adjusting for covariates, the burn cohort experienced significantly elevated admission rates for influenza and viral pneumonia (IRR, 95%CI: 1.73, 1.27-2.36), bacterial pneumonia (IRR, 95%CI: 2.05, 1.85-2.27) and for other types of upper and lower respiratory infections (IRR, 95% CI: 2.38, 2.09-2.71). In the mouse study an increased viral titre was observed after burn injury, accompanied by a reduced CD8 response and increased NK and NKT cells in the draining lymph nodes. This data suggests burn patients are at long-term increased risk of infection due to sustained modulation of the immune response

Human marginal zone B cell development from early T2 progenitors.

B cells emerge from the bone marrow as transitional (TS) B cells that differentiate through T1, T2, and T3 stages to become naive B cells. We have identified a bifurcation of human B cell maturation from the T1 stage forming IgMhi and IgMlo developmental trajectories. IgMhi T2 cells have higher expression of α4β7 integrin and lower expression of IL-4 receptor (IL4R) compared with the IgMlo branch and are selectively recruited into gut-associated lymphoid tissue. IgMhi T2 cells also share transcriptomic features with marginal zone B cells (MZBs). Lineage progression from T1 cells to MZBs via an IgMhi trajectory is identified by pseudotime analysis of scRNA-sequencing data. Reduced frequency of IgMhi gut-homing T2 cells is observed in severe SLE and is associated with reduction of MZBs and their putative IgMhi precursors. The collapse of the gut-associated MZB maturational axis in severe SLE affirms its existence in health