Developing biodiversity assessment on a stand forest type management level in north-eastern Italy

This paper discusses a simple operative proposal, elaborated by a team of advisers to the Forestry Service of the Veneto administrative region (north-eastern Italy), concerning the definition of stand-level forest type biodiversity indicators and biodiversity oriented management provisions. Such tools are conceived to transfer biodiversity conservation understanding in current forest stand management practices. The developed assessment system is targeted to: maintenance and increase of the variability of forest landscape mosaic; conservation of species variability; creation of resource reservoirs. The following criteria and indicators are taken into consideration: spatial pattern (widespreadness, connectedness, species contagion potential), forest structure (uneven aged stands: percent of trees in three broad diameter classes; even aged stands: number of development stages and surface of each development stage), herbs/shrubs species (average, minimum and maximum number of species; average number of short-lived herb/ shrub species recorded in minimal anthropic disturbance conditions; dynamic trend in the number of herb/shrub species), bird species (average, minimum and maximum number of species); overall naturalistic quality (flora; vegetation; fauna). Such indicators are proposed as biodiversity reference standards for each forest type in the considered region: they provide practical baseline information with which forest stand management efficiency in achieving biodiversity targets can be compared

Historicizing Entrepreneurial Imprinting: Sensitive Periods, Cognitive Frames and Resistance

Literature in strategy and entrepreneurship resorted to the concept of imprinting to explain the resilience of firms’ traits. Nonetheless, it assumed such a process is at work rather than aiming at its explanation. This article advances a conceptual framework based on three main building blocks - cognitive frame, resource mobilization, and resisting entrepreneurs - combined in a historical perspective, overcoming the existing generalized confusion about "what to study" and "how to study" in the investigation of entrepreneurial imprinting. We offer an original definition of the imprints and a dynamic view based on resistance investigating the replication, substitution, and re-negotiation of imprints in time. The contribution of the present work is twofold: on the one side, it contributes to the ongoing debate on entrepreneurial imprinting by closing some of the gaps that characterized previous literature on the subject, and offering an innovative bridging between imprinting and resistance; on the other side, it answers to the recent call for a deeper integration between historical approaches and entrepreneurship literature

Fatigue in Multiple Sclerosis: a resting-state EEG microstate study

Fatigue affects approximately 80% of people with Multiple Sclerosis (PwMS) and can impact several domains of daily life. However, the neural underpinnings of fatigue in MS are still not completely clear. The aim of our study was to investigate the spontaneous large-scale networks functioning associated with fatigue in PwMS using the EEG microstate approach with a spectral decomposition. Forty-three relapsing-remitting MS patients and twenty-four healthy controls (HCs) were recruited. All participants underwent an administration of Modified Fatigue Impact scale (MFIS) and a 15-min resting-state high-density EEG recording. We compared the microstates of healthy subjects, fatigued (F-MS) and non-fatigued (nF-MS) patients with MS; correlations with clinical and behavioral fatigue scores were also analyzed. Microstates analysis showed six templates across groups and frequencies. We found that in the F-MS emerged a significant decrease of microstate F, associated to the salience network, in the broadband and in the beta band. Moreover, the microstate B, associated to the visual network, showed a significant increase in fatigued patients than healthy subjects in broadband and beta bands. The multiple linear regression showed that the high cognitive fatigue was predicted by both an increase and decrease, respectively, in delta band microstate B and beta band microstate F. On the other hand, higher physical fatigue was predicted with lower occurrence microstate F in beta band. The current findings suggest that in MS the higher level of fatigue might be related to a maladaptive functioning of the salience and visual network

pH-Controlled Liposomes for Enhanced Cell Penetration in Tumor Environment

An innovative pH-switchable colloidal system that can be exploited for site-selective anticancer drug delivery has been generated by liposome decoration with a new novel synthetic non-peptidic oligo-arginine cell-penetration enhancer (CPE) and a quenching PEGylated counterpart that detaches from the vesicle surface under the acidic conditions of tumors. The CPE module (Arg(4)-DAG) is formed by four arginine units conjugated to a first-generation (G1) 2,2-bis(hydroxymethyl)propionic acid (bis-MPA)/2,2-bis(aminomethyl)propionic acid (bis-AMPA) polyester dendron terminating with 1,2-distearoyl-3-azidopropane for liposome bilayer insertion. The zeta potential of the Arg(4)-DAG-decorated liposomes increased up to +32 mV as the Arg(4)-DAG/lipids molar ratio increased. The Arg(4)-DAG liposome shielding at pH 7.4 was provided by methoxy-PEGS(5 kDa)-polymethacryloyl sulfadimethoxine (mPEG(5) (kDa)-SDM8) with 7.1 apparent pK(a). Zeta potential, surface plasmon resonance and synchrotron small-angle X-ray scattering analyses showed that at pH 7.4 mPEG(5) (kDa)-SDM8 associates with polycationic Arg(4)-DAG-decorated liposomes yielding liposomes with neutral zeta potential. At pH 6.5, which mimics the tumor environment, mPEG(5) (kDa)-SDM8 detaches from the liposome surface yielding Arg(4)-DAG exposure. Flow cytometry and confocal microscopy showed a 30-fold higher HeLa cancer cell association of the Arg(4)-DAG-decorated liposomes compared to non-decorated liposomes. At pH 7.4, the mPEG(5) (kDa)-SDM8-coated liposomes undergo low cell association while remarkable cell association occurred at pH 6.5, which allowed for the controlled intracellular delivery of model macromolecules and small molecules loaded in the liposome under tumor conditions.Peer reviewe

Strategies for the deployment of microclimate sensors in spaces housing collections

[EN] The study of the microclimate is pivotal for the protection and conservation of cultural heritage. This paper describes specifc procedures aimed at the deployment of microclimate sensors in spaces housing collections (e.g., museums) under diferent scenarios. The decision making involves a multidisciplinary discussion among museum manager, con¿ servator and conservation scientist and implies fve steps. Since the sensor¿s deployment depends on the number of available sensors, we have identifed two possible circumstances: (a) artwork-related deployment (i.e., there are as many sensors as the number of artworks) and (b) artwork-envelope-related deployment (i.e., the number of available sensors is less than the number of artworks). The former circumstance is advisable when the artwork is often moved from a museum to another one. The latter circumstance is usually the case of permanent collections, and, according to the Museum Scenario (MS), the related procedures can be further subdivided into basic (MSI and MSII) and advanced (MSIII and MSIV). Advanced procedures are preferable over basic procedures when several time series of microcli¿ mate data have been collected for at least one calendar year in several sampling points. All these procedures make it possible to design where to deploy sensors both in the case of an initial deployment and of optimisation of already installed sensors.This research was funded by the European Union's Horizon 2020 research and innovation program under grant agreement No.814624.Frasca, F.; Verticchio, E.; Peiró-Vitoria, A.; Grinde, A.; Bile, A.; Chimenti, C.; Conati Barbaro, C.... (2022). Strategies for the deployment of microclimate sensors in spaces housing collections. Heritage Science. 10(1):1-17. https://doi.org/10.1186/s40494-022-00831-111710

Ecological Momentary Assessment of Awake Bruxism Behaviors: A Scoping Review of Findings from Smartphone-Based Studies in Healthy Young Adults

Background: The recent introduction of ecological momentary assessment (EMA) smartphone-based strategies has allowed achieving some interesting data on the frequency of different awake bruxism (AB) behaviors reported by an individual in the natural environment. Objective: The present paper aims to review the literature on the reported frequency of AB based on data gathered via smartphone EMA technology. Methods: On September 2022, a systematic search in the Pubmed, Scopus and Google Scholar databases was performed to identify all peer-reviewed English-language studies assessing awake bruxism behaviors using a smartphone-based Ecological Momentary Assessment. The selected articles were assessed independently by two authors according to a structured reading of the articles’ format (PICO). Results: A literature search, for which the search terms “Awake Bruxism” and “Ecological Momentary Assessment” were used, identified 15 articles. Of them, eight fulfilled the inclusion criteria. The results of seven studies using the same smartphone-based app reported a frequency of AB behaviors in the range between 28.3 and 40% over one week, while another investigation adopted a different smartphone-based EMA approach via WhatsApp using a web-based survey program and reported an AB frequency of 58.6%. Most included studies were based on convenience samples with limited age range, highlighting the need for more studies on other population samples. Conclusions: Despite the methodological limits, the results of the reviewed studies provide a standpoint for comparison for future studies on the epidemiology of awake bruxism behaviors

Erasmus+ higher education impact study

Between 2014 and 2018, two million students and staff in higher education undertook a learning, training or teaching period abroad with the new Erasmus+ programme. The objective of the study was to assess the impact of Erasmus+ mobilities on staff, students and higher education institutions. It was based on almost 77,000 survey responses from these groups

Insight in cognitive impairment assessed with the Cognitive Assessment Interview in a large sample of patients with schizophrenia

The Cognitive Assessment Interview (CAI) is an interview-based scale measuring cognitive impairment and its impact on functioning in subjects with schizophrenia (SCZ). The present study aimed at assessing, in a large sample of SCZ (n = 601), the agreement between patients and their informants on CAI ratings, to explore patients' insight in their cognitive deficits and its relationships with clinical and functional indices. Agreement between patient- and informant-based ratings was assessed by the Gwet's agreement coefficient. Predictors of insight in cognitive deficits were explored by stepwise multiple regression analyses. Patients reported lower severity of cognitive impairment vs. informants. A substantial to almost perfect agreement was observed between patients' and informants' ratings. Lower insight in cognitive deficits was associated to greater severity of neurocognitive impairment and positive symptoms, lower severity of depressive symptoms, and older age. Worse real-life functioning was associated to lower insight in cognitive deficit, worse neurocognitive performance, and worse functional capacity. Our findings indicate that the CAI is a valid co-primary measure with the interview to patients providing a reliable assessment of their cognitive deficits. In the absence of informants with good knowledge of the subject, the interview to the patient may represent a valid alternative