Professor-Librarian Team-Teaching: Online Lifelong Training in the University

The article describes a case study of lifelong e-training for postgraduates delivered jointly by the Carlos III University of Madrid and Spain’s National Library from 2011 to 2017. It addresses course and participant characteristics as well as the results of an assessment aimed to determine both student satisfaction and effective skill transfer to the work environment. This unique professional training initiative may serve as a model in an area where librarians and professors are seldom seen to collaborate in online training on an equal footing

Infomediation and post-truth: The role of libraries

Análisis de la posverdad y, especialmente, del fenómeno subyacente de las fake news (noticias falsas) en lo que atañe a la evaluación y capacidad para identificar fuentes fiables y el papel de las bibliotecas como infomediarias. Se revisan las principales iniciativas internacionales propuestas por organismos como la IFLA o la ALA y se proponen, a tenor de la bibliografía consultada, dos principales vías de actuación: la inclusión en programas de alfabetización informacional, principalmente ampliando las alfabetizaciones mediáticas para que estén orientadas desde una perspectiva más cívica; y la curación de contenidos, realizando guías temáticas que sean un punto de información sobre el fenómeno y sus herramientas de verificación de hechos, pero que también actúen de pasarela para difundir información propia de la colección de la biblioteca.Analysis of post-truth and, especially, of the underlying phenomenon of fake news in terms of evaluation and ability to identify reliable sources, and the role of libraries as infomediaries. The main international initiatives proposed by organizations such as IFLA and ALA are discussed. According to the bibliography reviewed, two main kinds of action are proposed: inclusion in informational literacy programs, mainly extending media literacy so that they are oriented from a more civic perspective; and content curation, making thematic guides that are a point of information about the phenomenon and its tools to verify facts. Libraries should act also as a gateway to disseminate information of the library’s collectio

Evaluation of taste aversion learning procedure for the generalization of aversion using palatable foods

An experiment to evaluate the effectiveness of the taste aversion conditioning paradigm in the generalization of aversion with palatable foods was performed. Ten experimentally naive females Wistar rats and three types of foods were used: a) standard purina rodent chow, b) vanilla flavor cookies and c) chocolate-flavored cookies. Subjects were divided into two groups. Using the taste aversion conditioning paradigm protocol, subjects were exposed to the types of food keeping an intake record. The experiment demonstrated that rats can acquire an aversion to palatable foods accompanied by a tendency to generalize, when using elements that share characteristics such as nutritional content and texture. In addition, the intake of a food that does not share the characteristics of texture, taste, smell and energy content with the one used for conditioning was not been affected. These findings indicate that the aversion generalization seems to depend on the properties of the food used

Modalidad auxiliar de investigación: Acta de Evaluación de trabajo de grado en modalidad auxiliar de investigación, para obtener el titulo de Doctor en Cirugía Dental, en el proyecto titulado “Conocimientos, actitudes y Prácticas en salud bucal en población salvadoreña en el año 2022”

Acta finalización de proceso de grado de nueve estudiantes, quienes finalizaron su trabajo de investigación durante periodo de enero 2021 a diciembre 2021, lo que justifica finalización de requisito en Modalidad Auxiliar de investigación del proyecto del Centro de Investigaciones de la Facultad de Odontología de la Universidad de El Salvador, titulado: “Conocimientos, actitudes y Prácticas en salud bucal en población salvadoreña en el año 2022” para obtener el título de Doctor en Cirugía Dental de la Facultad de Odontología de la universidad de el salvador. Por tanto, se da por finalizado su trabajo de grado en modalidad auxiliar de investigación, el día trece de de febrero de dos mil veintitrés

Infequus: plataforma de enfermedades infecciosas equinas

Desarrollo de la herramienta de formación online Infequus, que ofrecerá a los alumnos y profesionales información actualizada sobre el diagnóstico y control de las enfermedades infecciosas en la especie equina

Modalidad auxiliar de investigación: Acta de Evaluación de trabajo de grado en modalidad auxiliar de investigación, para obtener el titulo de Doctor en Cirugía Dental, en el proyecto titulado “Conocimientos, actitudes y Prácticas en salud bucal en población salvadoreña en el año 2022”

Acta finalización de proceso de grado de nueve estudiantes, quienes finalizaron su trabajo de investigación durante periodo de enero 2021 a diciembre 2021, lo que justifica finalización de requisito en Modalidad Auxiliar de investigación del proyecto del Centro de Investigaciones de la Facultad de Odontología de la Universidad de El Salvador, titulado: “Conocimientos, actitudes y Prácticas en salud bucal en población salvadoreña en el año 2022” para obtener el título de Doctor en Cirugía Dental de la Facultad de Odontología de la universidad de el salvador. Por tanto, se da por finalizado su trabajo de grado en modalidad auxiliar de investigación, el día trece de de febrero de dos mil veintitrés

Infequus 2.0: Plataforma de enfermedades infecciosas en équidos

Depto. de Producción AnimalDepto. de Sanidad AnimalFac. de VeterinariaCentro de Vigilancia Sanitaria Veterinaria (VISAVET)FALSEsubmitte

Towards precision medicine: defining and characterizing adipose tissue dysfunction to identify early immunometabolic risk in symptom-free adults from the GEMM family study

Interactions between macrophages and adipocytes are early molecular factors influencing adipose tissue (AT) dysfunction, resulting in high leptin, low adiponectin circulating levels and low-grade metaflammation, leading to insulin resistance (IR) with increased cardiovascular risk. We report the characterization of AT dysfunction through measurements of the adiponectin/leptin ratio (ALR), the adipo-insulin resistance index (Adipo-IRi), fasting/postprandial (F/P) immunometabolic phenotyping and direct F/P differential gene expression in AT biopsies obtained from symptom-free adults from the GEMM family study. AT dysfunction was evaluated through associations of the ALR with F/P insulin-glucose axis, lipid-lipoprotein metabolism, and inflammatory markers. A relevant pattern of negative associations between decreased ALR and markers of systemic low-grade metaflammation, HOMA, and postprandial cardiovascular risk hyperinsulinemic, triglyceride and GLP-1 curves was found. We also analysed their plasma non-coding microRNAs and shotgun lipidomics profiles finding trends that may reflect a pattern of adipose tissue dysfunction in the fed and fasted state. Direct gene differential expression data showed initial patterns of AT molecular signatures of key immunometabolic genes involved in AT expansion, angiogenic remodelling and immune cell migration. These data reinforce the central, early role of AT dysfunction at the molecular and systemic level in the pathogenesis of IR and immunometabolic disorders

Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008–11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003–13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 × 10−10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 × 10−8 DHFR p=8·37 × 10−7 MTRNR2L2 p=2·15 × 10−9) and to a lesser extent in REGISTRY (MSH3 p=9·36 × 10−4 DHFR p=8·45 × 10−4 MTRNR2L2 p=1·20 × 10−3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 × 10−8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16–0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06–0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation