Microwave assisted synthesize of new some benzimidazole derivatives and determination of protonation constant of these compounds in non-aqueous media

A series of 2-substituted benzimidazole derivatives have been synthesized via microwave mediated process. Different benzimidazole derivatives were titrated with tetrabutylammonium hydroxide in four non-aqueous solvents (isopropyl alcohol, N,N-dimethylformamide,tert-butyl alcohol and acetonitrile), using potentiometric method. The half neutralization potential values and the corresponding pKa values were determined for all cases

Foam Sclerotherapy versus surgery in treatment of chronic venous disease

Although the classical surgical treatment methods of chronic venous insufficiency are successful to relieve perfectly the cause (reflux) and result (varicose veins), the new ablation techniques such as endogenous laser ablation therapy (EVLT), radiofrequency (RF) and foam ablation come into currency more and more with their advantage of being performed with only local anesthesia. However, these techniques, still have the potential for residual saphenofemoral reflux due to incomplete ablation of all side branches of the saphenofemoral junction. As an alternative technique ligation + foam sclerotherapy is not only comfortable like EVLT or RF but also safe and effective as much as classic stripping

Varicose vein surgery versus foam sclereotherapy to prevent extension of venous reflux with time

In the treatment of Chronic Venous Insufficiency (CVI) High Ligation (HL) and stripping of the saphenous varicose veins, and percutaneous phlebectomy have been the main options for many years. Modern management of CVI includes treatment of the cause (reflux) and result (varicose veins). Reflux should be treated before varicosities because if the cause is not eliminated, the varicose veins will recur [1].</p

An Alternative Treatment for Varicose Veins: Ligation Plus Foam Sclerotherapy

WOS: 000289155400011PubMed ID: 21481066BACKGROUND Varicose vein treatment has been directed toward less-invasive yet lasting techniques. OBJECTIVE To compare the effectiveness of an alternative treatment (ligation plus foam sclerotherapy) with that of a classic stripping technique. MATERIALS AND METHODS The study included 216 and 156 patients who had undergone classic stripping and foam sclerotherapy, respectively, within the previous 5 years. Preoperative and postoperative CEAP class, symptoms, recurrence, and Doppler findings of the two groups were compared. RESULTS There were no differences between treatments in terms of postoperative symptoms, Doppler findings, or CEAP class. The predictors of postoperative CEAP class were bilateral limb disease and prior deep vein thrombosis (DVT), whereas the predictors of symptom recurrence were bilateral limb disease, preoperative CEAP class, occupation, and familial or genetic predisposition. The predictors of postoperative perforator incompetence (PI) were occupation, aged 60 and older, preoperative CEAP class, and preoperative PI, whereas the only predictor of postoperative deep vein incompetence (DVI) was preoperative DVI. Five-year symptom-free survival rates were 5170.8% in the foam sclerotherapy group and 4670.9% in the stripping group. CONCLUSION The safety and efficacy of ligation plus foam sclerotherapy as an alternative technique allowing for same-day surgery to treat varicose veins are the same as those of classic stripping. The predictors of postoperative outcome depend on individual patient characteristics

Determination of the protonation constants of some 4-(substituted benzylamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones by the potentiometric method in ethanol-water mixtures

To gain more information about the effect of solvent on 4,5-dihydro-1H-1,2,4-triazol-5-ones, the stoichiometric protonation constants of thirteen triazoles in ethanol-water mixtures were determined at an ionic strength of 0.10 M NaCl and at 25.0 +/- 0.1 degrees C under nitrogen atmosphere. A potentiometric method was used and the calculation was carried out using the PKAS computer program. The correspondingpK(a) values of these triazoles were determined in ethanol-water mixtures. Thus, the effects of solvent and molecular structure upon acidity were investigated. The logarithm of the protonation constants of the title 4,5-dihydro-1H- 1,2,4-triazol-5-ones decreased linearly with increasing ethanol content, but the values determined with 80% ethanol did not follow this linear trend. The variation of these constants is discussed on the basis of specific solute-solvent interactions

Comparative analysis of the results of cyanoacrylate ablation and radiofrequency ablation in the treatment of venous insufficiency

46th Annual VEITH Symposium -- NOV 19-23, 2019 -- New York, NYBackground: Varicose vein treatment has shifted to less invasive techniques owing to the complications associated with traditional treatment. The present study was designed to compare the effectiveness of cyanoacrylate ablation (CAA) with radiofrequency ablation (RFA). Methods: Patients who had undergone RFA vs CAA (634 vs 246 patients) to treat great saphenous vein (GSV) insufficiency during a 5-year period were included in the present study. The preoperative and postoperative CEAP (clinical, etiologic, anatomic, pathophysiologic) class, symptoms, recurrence, and Doppler ultrasound findings were compared. Results: All the veins in both groups were occluded at day 5. The 1-month closure rates were 97.3% and 98.7% for RFA and CAA, respectively. The overall postoperative closure rates at 5 years were 93.1% and 91.1% for RFA and CAA, respectively. The postoperative symptoms, CEAP class, and Doppler ultrasound findings were similar in both groups. The 5-year symptom-free survival rates were 73.5% and 72.0% in the RFA and CAA groups, respectively. The venous clinical severity scores had decreased from 5.9 +/- 1.2 to 0.9 +/- 0.8 and 5.8 +/- 0.9 to 0.8 +/- 0.6 in the RFA and CAA groups, respectively. The Aberdeen varicose vein questionnaire scores had decreased from 19.7 +/- 5.5 to 4.8 +/- 1.5 in the RFA group and from 18.9 +/- 5.8 to 4.9 +/- 1.4 in the CAA group. Conclusions: CAA seems to be the ideal treatment for GSV insufficiency because it is suitable for most patients and is nonthermal and nontumescent, with satisfactory results comparable to those with RFA. Long-term outcomes and cost analyses from larger series are required to confirm our findings.VEIT

Rapid and efficient synthesis of a new series of 2-aryl-5-fluoro-6(4-phenylpiperazin-1-yl)-1H-benzimidazoles using microwave heating

WOS: 000360201000005A new series of 2-aryl-5-fluoro-6-(4-phenylpiperazin-1-yl)-1H-benzimidazoles was synthesised from the reaction of 4-fluoro-5-(4-phenylpiperazin-1-yl) benzene-1,2-diamine and iminoester hydrochlorides. 4-Fluoro-5-(4-phenylpiperazin-1-yl) benzene-1,2-diamine was prepared from the reduction of 5-fluoro-2-nitro-4-(4-phenylpiperazin-1-yl) aniline by using Pd/C (10%) catalyst and hydrazine hydrate under microwave irradiation. the structures of newly synthesised compounds were identified by H-1 NMR, C-13 NMR, mass spectroscopy and elemental analysis data