Circular Proofs as Session-Typed Processes: A Local Validity Condition

Proof theory provides a foundation for studying and reasoning about programming languages, most directly based on the well-known Curry-Howard isomorphism between intuitionistic logic and the typed lambda-calculus. More recently, a correspondence between intuitionistic linear logic and the session-typed pi-calculus has been discovered. In this paper, we establish an extension of the latter correspondence for a fragment of substructural logic with least and greatest fixed points. We describe the computational interpretation of the resulting infinitary proof system as session-typed processes, and provide an effectively decidable local criterion to recognize mutually recursive processes corresponding to valid circular proofs as introduced by Fortier and Santocanale. We show that our algorithm imposes a stricter requirement than Fortier and Santocanale's guard condition, but is local and compositional and therefore more suitable as the basis for a programming language.Comment: The revised version, 48 pages, submitted to Logical Methods in Computer Scienc

Circular Proofs as Session-Typed Processes: A Local Validity Condition

Proof theory provides a foundation for studying and reasoning about programming languages, most directly based on the well-known Curry-Howard isomorphism between intuitionistic logic and the typed lambda-calculus. More recently, a correspondence between intuitionistic linear logic and the session-typed pi-calculus has been discovered. In this paper, we establish an extension of the latter correspondence for a fragment of substructural logic with least and greatest fixed points. We describe the computational interpretation of the resulting infinitary proof system as session-typed processes, and provide an effectively decidable local criterion to recognize mutually recursive processes corresponding to valid circular proofs as introduced by Fortier and Santocanale. We show that our algorithm imposes a stricter requirement than Fortier and Santocanale's guard condition, but is local and compositional and therefore more suitable as the basis for a programming language

Logical Relations for Session-Typed Concurrency

Program equivalence is the fulcrum for reasoning about and proving properties of programs. For noninterference, for example, program equivalence up to the secrecy level of an observer is shown. A powerful enabler for such proofs are logical relations. Logical relations only recently were adopted for session types -- but exclusively for terminating languages. This paper scales logical relations to general recursive session types. It develops a logical relation for progress-sensitive noninterference (PSNI) for intuitionistic linear logic session types (ILLST), tackling the challenges non-termination and concurrency pose, and shows that logical equivalence is sound and complete with regard to closure of weak bisimilarity under parallel composition, using a biorthogonality argument. A distinguishing feature of the logical relation is its stratification with an observation index (as opposed to a step or unfolding index), a crucial shift to make the logical relation closed under parallel composition in a concurrent setting. To demonstrate practicality of the logical relation, the paper develops an information flow control (IFC) refinement type system for ILLST, with support of secrecy-polymorphic processes, and shows that well-typed programs are self-related by the logical relation and thus enjoy PSNI. The refinement type system has been implemented in a type checker, featuring local security theories to support secrecy-polymorphic processes.Comment: arXiv admin note: text overlap with arXiv:2208.1374

Platinum Nanoparticles in Biomedicine: Preparation, Anti-Cancer Activity, and Drug Delivery Vehicles

Cancer is the main cause of morbidity and mortality worldwide, excluding infectious disease. Because of their lack of specificity in chemotherapy agents are used for cancer treatment, these agents have severe systemic side effects, and gradually lose their therapeutic effects because most cancers become multidrug resistant. Platinum nanoparticles (PtNPs) are relatively new agents that are being tested in cancer therapy. This review covers the various methods for the preparation and physicochemical characterization of PtNPs. PtNPs have been shown to possess some intrinsic anticancer activity, probably due to their antioxidant action, which slows tumor growth. Targeting ligands can be attached to functionalized metal PtNPs to improve their tumor targeting ability. PtNPs-based therapeutic systems can enable the controlled release of drugs, to improve the efficiency and reduce the side effects of cancer therapy. Pt-based materials play a key role in clinical research. Thus, the diagnostic and medical industries are exploring the possibility of using PtNPs as a next-generation anticancer therapeutic agent. Although, biologically prepared nanomaterials exhibit high efficacy with low concentrations, several factors still need to be considered for clinical use of PtNPs such as the source of raw materials, stability, solubility, the method of production, biodistribution, accumulation, controlled release, cell-specific targeting, and toxicological issues to human beings. The development of PtNPs as an anticancer agent is one of the most valuable approaches for cancer treatment. The future of PtNPs in biomedical applications holds great promise, especially in the area of disease diagnosis, early detection, cellular and deep tissue imaging, drug/gene delivery, as well as multifunctional therapeutics

Landscape evolution, post-LGM surface denudation and soil weathering processes from Dickinson Park mire, Wind River Range, Wyoming (USA)

At mid-latitudes, the transition from the Pleistocene to the Holocene was characterised by distinct and partially abrupt climatic changes. Also during the Holocene, climatic perturbations, with sometimes cold-dry conditions, have occurred. How land surfaces and soil development processes in high-mountains respond to these climatic oscillations is so far only poorly known. We traced the responses of surfaces in the alpine settings of the Wind River Range (Wyoming, US) by using a large mire as natural archive. This enabled us to reconstruct environmental conditions and ecosystem changes during the Holocene in this montane area. Although adjacent moraine deposits display 10Be exposure ages from the Last Glacial Maximum up to MIS16 or even older, the accessible sediment deposits covered only the Holocene (via radiocarbon dating). By applying a geoforensic approach and deriving sedimentation rates, major climatic signals were detected. A higher deposition (and consequently erosion) rate and thus a higher rate of geomorphic activity was measured for the known cold periods 9.4–10.2 ka BP, 4.2 ka BP and 2.5 ka BP. During the LIA, especially rapid aggradation of organic matter organic matter took place here. Rates of chemical weathering and soil formation seem to have been relatively low until about 5–6 ka BP but have since increased during the Late Holocene. This would fit previous observations of increasing moisture conditions after the mid-Holocene aridity period. In contrast to several other studies, no clear signs of major disturbances (erosion, weathering) during the 8.2 ka event could be observed. Together with the low levels of chemical weathering found here, we do not see any evidence that the climate was more humid during this period. Compared to previous findings, more humid conditions seemed to have returned earlier, i.e. about 5 kyr BP. In general, this landscape displayed a patchy pattern of reaction to environmental changes, as all events were not recorded in each mire profile

Relating the spatial variability of chemical weathering and erosion to geological and topographical zones

The relationship between the spatial variability of soil elements, weathering and erosion rates can be very complex. Topography, abruptly-changing elevation gradients and slopes of varying geological composition exert an important influence on weathering trajectories and erosion. This complex interconnectivity is only rarely addressed in weathering studies. The main objectives of this investigation are, therefore, to relate weathering and erosion to various and geomorphic units in a dry-alpine and threshold landscape having steep slopes (Kan catchment, Tehran Province, Iran). A number of common weathering indices were tested using a genetic algorithm. The best indices are the (K + Na)/Ti ratio, the WIP (weathering index according to Parker), and the PI (product index according to Ruxton). However, the recently suggested 4Si-M+-R2 and M-F-Wmin systems discriminate weathering trends more accurately. Our results show that these soils have a low to moderate weathering stage. Weathering trajectories point to the active formation of kaolinite and oxyhydroxides. River sediments are slightly more weathered and contain the most-weathered topsoils and suggest erosion in the catchment is predominantly due to topsoil removal. Chemical weathering is influenced by the dominant geomorphic units (unconsolidated deposits of the Quaternary and solid bedrock) and landform features (combination of altitude and slope). Aspect does not appear to have a significant impact on weathering. Denudation (~erosion) rates were determined using meteoric 10Be since the fluvial sediments did not contain enough quartz for in situ 10Be analyses. This procedure has higher uncertainties due to difficulties in estimating the depositional flux of meteoric 10Be. Due to tectonic uplift, the erosion rates are very high. To maintain a soil layer, soil production rates must be also high. Although annual precipitation is relatively low, slope and soil dynamics seem particularly high, which leads to a fast turnover of the soil material and maintains the weathering intensity at a rather low to intermediate level

Medical students' perceptions towards distance e-Learning in gynecology ward during the COVID-19 pandemic.

IntroductionThe coronavirus disease 2019 (COVID-19) pandemic has caused serious public health problems and compromised the health of individuals and communities. This study aimed to evaluate a Distance e-Learning from the perspective of medical students in the Gynecology ward during the COVID-19 Pandemic.Material and methodsThis cross-sectional study was conducted at the Iran University of Medical from the September 2020 to September 2021. The study sample included 130 medical students who participated in distance training courses in the gynecology ward during the COVID-19 pandemic. All medical students were included for the study. Medical students (externs and interns), who received Distance eLearning in the gynecology ward during the study, were included. The self-administered questionnaire was used in this study. Questionnaires was developed through literature review and consultation with gynecology and eLearning experts. Face and content validity was established by eight experts. Internal consistency was assessed with Cronbach's alpha.ResultsThe questionnaire was sent to 170 medical students. Of the 130 respondents 65% were female and 35% were male. There were 57 (43.8%) externs and 73 (56.2) interns. Most students agreed that mobile devices increase their learning and home is the preferred place for participation in DE. Most students (66.9%) either strongly disagreed or disagreed that Distance e-Learning was an appropriate method for learning basic clinical skills.72.3% of respondents strongly disagreed or disagreed that Distance e-Learning provided them an opportunity to practice clinical skills effectively. Most medical students (69.3%) strongly agreed or agreed that Distance e-Learning created more opportunities to apply theoretical knowledge directly to medical practice.DiscussionThe results of the online survey suggest that medical students have found both positive and negative aspects of clinical learning by DEL format in Gynecology ward

Mucoepidermoid carcinoma of the palate in a patient with a history of neuroblastoma: A case report and a review of the literature

Abstract Secondary neoplasms were reported as one of the complicated complications of childhood cancer treatment. Salivary gland carcinoma is rare, and mucoepidermoid carcinoma (MEC) is the most prevalent subtype. Secondary neoplasms following neuroblastoma are not often described due to poor long‐term survival. The exact cause of these tumors in children, and adults is not clearly known, but they are often observed after head, and neck radiotherapy and mainly involve main salivary glands, especially the parotid. Hence, we report a case of MEC with telangiectasia in the salivary glands of a 20‐year‐old girl with complaint of a palatal swelling who was treated with chemotherapy (etoposide, G‐CSF, cyclophosphamide) without radiotherapy since childhood (18 months) in terms of neuroblastoma. Based on our knowledge, only three cases of MEC following neuroblastoma have been reported before, all of which involved the major salivary glands. Survivors of primary neoplasms who were treated are at risk of secondary malignant neoplasms, which usually occur at a long interval from the primary neoplasm (5–15 years), which necessitates long and close follow‐up