Prenatal metal(loid) mixtures and birth weight for gestational age: A pooled analysis of three cohorts participating in the ECHO program

Background: A growing number of studies have identified both toxic and essential metals which influence fetal growth. However, most studies have conducted single-cohort analyses, which are often limited by narrow exposure ranges, and evaluated metals individually. The objective of the current study was to conduct an environmental mixture analysis of metal impacts on fetal growth, pooling data from three geographically and demographically diverse cohorts in the United States participating in the Environmental Influences on Child Health Outcomes program. Methods: The pooled sample (N = 1,002) included participants from the MADRES, NHBCS, and PROTECT cohorts. Associations between seven metals (antimony, cadmium, cobalt, mercury, molybdenum, nickel, tin) measured in maternal urine samples collected during pregnancy (median: 16.0 weeks gestation) and birth weight for gestational age z-scores (BW for GA) were investigated using Bayesian Kernel Machine Regression (BKMR). Models were also stratified by cohort and infant sex to investigate possible heterogeneity. Chromium and uranium concentrations fell below the limits of detection for most participants and were evaluated separately as binary variables using pooled linear regression models. Results: In the pooled BKMR analysis, antimony, mercury, and tin were inversely and linearly associated with BW for GA, while a positive linear association was identified for nickel. The inverse association between antimony and BW for GA was observed in both males and females and for all three cohorts but was strongest for MADRES, a predominantly low-income Hispanic cohort in Los Angeles. A reverse j-shaped association was identified between cobalt and BW for GA, which was driven by female infants. Pooled associations were null for cadmium, chromium, molybdenum, and uranium, and BKMR did not identify potential interactions between metal pairs. Conclusions: Findings suggest that antimony, an understudied metalloid, may adversely impact fetal growth. Cohort- and/or sex-dependent associations were identified for many of the metals, which merit additional investigation

Parametrizing the lepton mixing matrix in terms of deviations from tri-bimaximal mixing

We propose a parametrization of the lepton mixing matrix in terms of an expansion in powers of the deviations of the reactor, solar and atmospheric mixing angles from their tri-bimaximal values. We show that unitarity triangles and neutrino oscillation formulae have a very compact form when expressed in this parametrization, resulting in considerable simplifications when dealing with neutrino phenomenology. The parametrization, which is completely general, should help to establish possible relations between the deviations of the reactor, solar and atmospheric mixing angles from their tri-bimaximal values, and hence enable models which predict such relations to be more directly compared to experiment.<br/

Physics at a future Neutrino Factory and super-beam facility

The conclusions of the Physics Working Group of the international scoping study of a future Neutrino Factory and super-beam facility (the ISS) are presented. The ISS was carried by the international community between NuFact05, (the 7th International Workshop on Neutrino Factories and Superbeams, Laboratori Nazionali di Frascati, Rome, June 21-26, 2005) and NuFact06 (Ivine, California, 24{30 August 2006). The physics case for an extensive experimental programme to understand the properties of the neutrino is presented and the role of high-precision measurements of neutrino oscillations within this programme is discussed in detail. The performance of second generation super-beam experiments, beta-beam facilities, and the Neutrino Factory are evaluated and a quantitative comparison of the discovery potential of the three classes of facility is presented. High-precision studies of the properties of the muon are complementary to the study of neutrino oscillations. The Neutrino Factory has the potential to provide extremely intense muon beams and the physics potential of such beams is discussed in the final section of the report.The conclusions of the Physics Working Group of the international scoping study of a future Neutrino Factory and super-beam facility (the ISS) are presented. The ISS was carried by the international community between NuFact05, (the 7th International Workshop on Neutrino Factories and Superbeams, Laboratori Nazionali di Frascati, Rome, June 21-26, 2005) and NuFact06 (Ivine, California, 24{30 August 2006). The physics case for an extensive experimental programme to understand the properties of the neutrino is presented and the role of high-precision measurements of neutrino oscillations within this programme is discussed in detail. The performance of second generation super-beam experiments, beta-beam facilities, and the Neutrino Factory are evaluated and a quantitative comparison of the discovery potential of the three classes of facility is presented. High-precision studies of the properties of the muon are complementary to the study of neutrino oscillations. The Neutrino Factory has the potential to provide extremely intense muon beams and the physics potential of such beams is discussed in the final section of the report

Flavour Physics of Leptons and Dipole Moments.

This chapter of the report of the ``Flavour in the era of the LHC'' Workshop discusses the theoretical, phenomenological and experimental issues related to flavour phenomena in the charged lepton sector and in flavour-conserving CP-violating processes. We review the current experimental limits and the main theoretical models for the flavour structure of fundamental particles. We analyze the phenomenological consequences of the available data, setting constraints on explicit models beyond the Standard Model, presenting benchmarks for the discovery potential of forthcoming measurements both at the LHC and at low energy, and exploring options for possible future experiments.Comment: Report of Working Group 3 of the CERN Workshop ``Flavour in the era of the LHC'', Geneva, Switzerland, November 2005 -- March 200