Indo-US Strategic Partnership: Implications for Pakistan

In the scheme of American grand strategy for the ‘new world order’, India has emerged as the most powerful regional ally. The emerging “strategic partnership” between the US and India is based on a shared view for democracy and concerns about the threat of global terrorism as well as mutual unease considering the long-term implications of the rise of China in Asia and beyond. US and India have complementary economic and strategic security interests as the former desires to maintain her economic and military supremacy in the world. India on her part wants to develop security ties with America to facilitate her becoming dominant regional and global power in the foreseeable future. Shared perception about ‘terrorism’ has further cemented their relations where India promptly endorses US stance on “War on Terrorism” with a hope to turn US interests to its advantage by labeling freedom struggle in Kashmir as Pakistan sponsored insurgency. Reflections of converging interests include: US-India Next Steps in Strategic Partnership (NSSP) initiative, signing of 123 Nuclear Agreement, missile defense, and ten-year defense framework agreement that calls for expanding bilateral security cooperation. Pakistan cannot afford to remain oblivious to these developments due to their security implications. Enhanced capacity building of Indian armed forces and nuclear collaborations may undermine the deterrent value of Pakistan's conventional and nuclear weapons. A combination of pragmatic foreign policy backed with credible conventional and nuclear deterrence could serve desired national security interests. While remaining strategically relevant to US, Islamabad will have to continue to cultivate good relationship with Beijing. On internal front, Pakistan must revive her economy and achieve more national cohesion so as to offset the negative effects of Indo-US strategic convergence

Randomize to Generalize: Domain Randomization for Runway FOD Detection

Tiny Object Detection is challenging due to small size, low resolution, occlusion, background clutter, lighting conditions and small object-to-image ratio. Further, object detection methodologies often make underlying assumption that both training and testing data remain congruent. However, this presumption often leads to decline in performance when model is applied to out-of-domain(unseen) data. Techniques like synthetic image generation are employed to improve model performance by leveraging variations in input data. Such an approach typically presumes access to 3D-rendered datasets. In contrast, we propose a novel two-stage methodology Synthetic Randomized Image Augmentation (SRIA), carefully devised to enhance generalization capabilities of models encountering 2D datasets, particularly with lower resolution which is more practical in real-world scenarios. The first stage employs a weakly supervised technique to generate pixel-level segmentation masks. Subsequently, the second stage generates a batch-wise synthesis of artificial images, carefully designed with an array of diverse augmentations. The efficacy of proposed technique is illustrated on challenging foreign object debris (FOD) detection. We compare our results with several SOTA models including CenterNet, SSD, YOLOv3, YOLOv4, YOLOv5, and Outer Vit on a publicly available FOD-A dataset. We also construct an out-of-distribution test set encompassing 800 annotated images featuring a corpus of ten common categories. Notably, by harnessing merely 1.81% of objects from source training data and amalgamating with 29 runway background images, we generate 2227 synthetic images. Subsequent model retraining via transfer learning, utilizing enriched dataset generated by domain randomization, demonstrates significant improvement in detection accuracy. We report that detection accuracy improved from an initial 41% to 92% for OOD test set.Comment: 29 pages, 9 figure

Micro-Endoscopic Discectomy versus Open Discectomy: A Struggle for Better Clinical Outcomes

Objective:  The objective of the current study was to compare the clinical outcomes of a micro-endoscopic discectomy with an open discectomy. Materials & Methods:  This Quasi-experimental study was conducted in the Department of Neurosurgery, Alrazi Healthcare, Lahore, and Ammar Medical Complex, Lahore. The sample consisted of 40 patients with lower back pain with radiation to the lower limbs. A lumbar disc single-segment hernia was diagnosed based on magnetic resonance imaging (MRI) findings. Independent sample t-test was used to explore the difference in outcomes and level of pain between group A and group B. Chi-square test was used to compare the recovery rate of patients in both groups. Results:  A significant difference between the two groups in terms of surgery duration (t = 15.977, P = .000), blood loss during surgery (t = -10.256, P = .000), length of incision (t = -58.355, P = .000), and hospital stay after surgery (t = -4.687, P = .000) was found. The overall recovery rate for the micro-endoscopic Discectomy group was 95% whereas, in the open discectomy group, it was 90%. Conclusion:  Micro-endoscopic discectomy is superior to open discectomy in terms of lesser surgical trauma, lesser blood loss, lesser hospital stay, earlier return to work, and higher pain resolution

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Influence of slip velocity on the flow of viscous fluid through a porous medium in a permeable tube with a variable bulk flow rate

A mathematical model is presented for an axisymmetric flow of a Newtonian fluid through a permeable tube filled with porous medium and slip at the wall. The bulk flow rate is prescribed as a decreasing function of axial distance. The governing coupled partial differential equations are solved analytically using Adomian decomposition method and numerically using a second order finite difference scheme. Numerical method is validated by already published work and a good agreement is observed between the two solutions. Trusting this validity, effects of pertinent parameters on the flow variables such as velocity components, wall shear stress and pressure drop are discussed graphically. This study reveals that the slip parameter (ϕ), reabsorption parameter (α) and permeability parameter (k) have significant influences on flow variables involved in the problem. Creeping flow (Re = 0), flow without porous medium (k→∞) and flow with no slip (ϕ=0) at the wall are the limiting cases of this study. Keywords: Permeable tube, Porous medium, Variable bulk flow rate, Partial sli

Genome-Wide Identification, Characterization, and Transcriptomic Analysis of the Cyclin Gene Family in Brassica rapa

Cyclins are involved in cell division and proliferation by activating enzymes required for the cell cycle progression. Our genome-wide analysis identified 76 cyclin genes in Brassica rapa, which were divided into nine different types (A-, B-, C-, D-, H-, L-, P-, T-, and SDS-type). Cyclin genes were unevenly scattered on all chromosomes, with a maximum of 10 on A08 and a minimum of 2 on A04. The gene structure and conserved motif analysis showed that the cyclins which belonged to the same type or subgroup have a comparable intron/exon pattern or motif. A total of 14 collinear gene pairs suggested that the B. rapa cyclin genes experienced a mass of segmental duplication. The Ka/Ks analysis revealed that the Brcyclin gene family has undergone an extensive purifying pressure. By analyzing the cis-elements in the promoters, we identified 11 cis-elements and five of them are related to the hormone response. We observed 48 potential miRNAs targeting 44 Brcyclin genes, which highlighted the involvement of miRNAs in the regulation of cyclin genes. An association analysis between the leaf size and SNPs in mutants and a transcriptome analysis of two Chinese cabbage-cabbage translocation lines also showed that the Brcyclin gene family was involved in the development of the leaves. The functional characterization of the B. rapa cyclin gene family will provide the foundation for future physiological and genetic studies in the regulation of leaf growth

Variation in Antioxidant Attributes at Three Ripening Stages of Guava (Psidium guajava L.) Fruit from Different Geographical Regions of Pakistan

The present investigation was carried out to appraise the levels of total phenols and vitamin C as well as antioxidant potential at three different ripening stages (un-ripe, semi-ripe and fully-ripe) of guava (Psidium guajava L.) fruit collected from three different geographical regions of Pakistan (Islamabad, Faisalabad and Bhakkar). The antioxidant potential of guava fruit extracts was assessed by means of different in-vitro antioxidant assays, namely inhibition of peroxidation in linoleic acid system, reducing power and radical scavenging capability. Overall, fruit at the un-ripe stage (G1) exhibited the highest levels of TPC, TFC, reducing power and DPPH radical scavenging activity, followed by the semi-ripe (G2) and fully-ripe (G3) stages. On the other hand, vitamin C content increased as the fruit maturity progressed, with highest value seen at the fully-ripe stage (G3) followed by the semi-ripe (G2) and un-ripe stage (G1). The concentration of vitamin C in fruits varied as: Faisalabad (136.4–247.9 mg 100 g−1), Islamabad (89.7–149.7 mg 100 g−1) and Bhakkar (73.1–129.5 mg 100 g−1). The results showed that different stages of maturation and geographical locations had profound effects on the antioxidant activity and vitamin C contents of guava fruit