Validation of a Physical and Numerical Model to Solve Problems of Seepage Flow

The coefficient of permeability (k value) is an important parameter in civil engineering practice, in hydrology and hydrogeology. It can be determined by field test or by means of laboratory testing. The goal of this paper is to assess this parameter by creating a laboratory model and by validating its results using finite element computer code. The model tests provide that can be applied for estimating permeability of different soils. In a physical model medium-grained sand was tested in the laboratory, for understanding the effects of different flow rates on the validation of the measurement result, the numerical simulation of the physical model was constructed using FEFLOW. Two model variants were developed and both variants were calibrated and validated. Subsequently, the results were converted to real variables based on the model laws. The physical model provides the flow rate of the well in medium-grained sand with sufficient accuracy if the real size of the drawdown is between 0,5 and 1,7 m

Halmazelmélet; Partíció kalkulus, Végtelen gráfok elmélete = Set Theory; Partition Calculus , Theory of Infinite Graphs

Előzetes tervünknek megfelelően a halmazelmélet alábbi területein végeztünk kutatást és értünk el számos eredményt: I. Kombinatorika II. A valósak számsosságinvariánsai és ideálelmélet III. Halmazelméleti topológia Ezek mellett Sági Gábor kiterjedt kutatást végzett a modellelmélet területén , amely eredmények kapcsolódnak a kombinatorikához is. Eredményeinket 38 közleményben publikáltuk, amelyek majdnem mind az adott terület vezető nemzetközi lapjaiban jelentel meg (5 cikket csak benyújtottunk). Számos nemzetközi konferencián is résztvettünk, és hárman közűlünk (Juhász, Sádi, Soukup) plenáris/meghívott előadók voltak számos alkalommal. | Following our research plan, we have mainly done research -- and established a number of significant results -- in several areas of set theory: I. Combinatorics II. Cardinal invariants of the continuum and ideal theory III. Set-theoretic topology In addition to these, G. Sági has done extended research in model theory that had ramifications to combinatorics. We presented our results in 38 publications, almost all of which appeared or will appear in the leading international journals of these fields (5 of these papers have been submitted but not accepted as yet). We also participated at a number of international conferences, three of us (Juhász, Sági, Soukup) as plenary and/or invited speakers at many of these

MiCADO -Microservice-based Cloud Application-level Dynamic Orchestrator

Various scientific and commercial applications require automated scalability and orchestration on cloud computing resources. However, extending applications with such automated scalability on an individual basis is not feasible. This paper investigates how such automated orchestration can be added to cloud applications without major reengineering of the application code. We suggest a generic architecture for an application level cloud orchestration framework, called MiCADO that supports various application scenarios on multiple heterogeneous federated clouds. Besides the generic architecture description, the paper also presents the first MiCADO reference implementation, and explains how the scalability of the Data Avenue service that is applied for data transfer in WS-PGRADE/gUSE based science gateways, can be improved. Performance evaluation of the implemented scalability based on up and downscaling experiments is presented

Efficacy, drug sustainability, and safety of ustekinumab treatment in Crohn’s disease patients over three years

Long-term data on ustekinumab in real-life Crohn’s disease patients are still missing, though randomized controlled trials demonstrated it as a favorable therapeutic option. We aimed to evaluate ustekinumab's clinical efficacy, drug sustainability, and safety in a prospective, nationwide, multicenter Crohn’s disease patient cohort with a three-year follow-up. Crohn’s disease patients on ustekinumab treatment were consecutively enrolled from 9 Hungarian Inflammatory Bowel Disease centers between January 2019 and May 2020. Patient and disease characteristics, treatment history, clinical disease activity (Harvey Bradshaw Index (HBI)), biomarkers, and endoscopic activity (Simple Endoscopic Score for Crohn’s Disease (SES-CD)) were collected for three-years’ time. A total of 148 patients were included with an overall 48.9% of complex behavior of the Crohn’s disease and 97.2% of previous anti-TNF exposure. The pre-induction remission rates were 12.2% (HBI), and 5.1% (SES-CD). Clinical remission rates (HBI) were 52.2%, 55.6%, and 50.9%, whereas criteria of an endoscopic remission were fulfilled in 14.3%, 27.5%, and 35.3% of the subjects at the end of the first, second, and third year, respectively. Dose intensification was high with 84.0% of the patients on an 8-weekly and 29.9% on a 4-weekly regimen at the end of year 3. Drug sustainability was 76.9% during the follow-up period with no serious adverse events observed. Ustekinumab in the long-term is an effective, sustainable, and safe therapeutic option for Crohn’s disease patients with severe disease phenotype and high previous anti-TNF biological failure, requiring frequent dose intensifications

VIALACTEA science gateway for Milky Way analysis

This paper presents the latest developments on the VIALACTEA Science Gateway in the context of the FP7 VIALACTEA project. The science gateway operates as a central workbench for the VIALACTEA community in order to allow astronomers to process the new-generation surveys (from Infrared to Radio) of the Galactic Plane to build and deliver a quantitative 3D model of our Milky Way Galaxy. The final model will be used as a template for external galaxies to study star formation across the cosmic time. The adopted agile software development process allowed to fulfill the community needs in terms of required workflows and underlying resource monitoring. Scientific requirements arose during the process highlighted the needs for easy parameter setting, fully embarrassingly parallel computations and large-scale input dataset processing. Therefore the science gateway based on the WS-PGRADE/gUSE framework has been able to fulfill the requirements mainly exploiting the parameter sweep paradigm and parallel job execution of the workflow management system. Moving from development to production environment an efficient resource monitoring system has been implemented to easily analyze and debug sources of potential failures occurred during workflow computations. The results of the resource monitoring system are exploitable not only for IT experts, administrators and workflow developers but also for the end-users of the gateway. The affiliation to the STARnet Gateway Federation ensures the sustainability of the presented products after the end of the project, allowing the usage of the VIALACTEA Science Gateway to all the stakeholders, not only to the community members. © 2017 Elsevier B.V

Quantitative analyses and modelling to support achievement of the 2020 goals for nine neglected tropical diseases

Quantitative analysis and mathematical models are useful tools in informing strategies to control or eliminate disease. Currently, there is an urgent need to develop these tools to inform policy to achieve the 2020 goals for neglected tropical diseases (NTDs). In this paper we give an overview of a collection of novel model-based analyses which aim to address key questions on the dynamics of transmission and control of nine NTDs: Chagas disease, visceral leishmaniasis, human African trypanosomiasis, leprosy, soil-transmitted helminths, schistosomiasis, lymphatic filariasis, onchocerciasis and trachoma. Several common themes resonate throughout these analyses, including: the importance of epidemiological setting on the success of interventions; targeting groups who are at highest risk of infection or re-infection; and reaching populations who are not accessing interventions and may act as a reservoir for infection,. The results also highlight the challenge of maintaining elimination ‘as a public health problem’ when true elimination is not reached. The models elucidate the factors that may be contributing most to persistence of disease and discuss the requirements for eventually achieving true elimination, if that is possible. Overall this collection presents new analyses to inform current control initiatives. These papers form a base from which further development of the models and more rigorous validation against a variety of datasets can help to give more detailed advice. At the moment, the models’ predictions are being considered as the world prepares for a final push towards control or elimination of neglected tropical diseases by 2020

Quantitative analyses and modelling to support achievement of the 2020 goals for nine neglected tropical diseases

Quantitative analysis and mathematical models are useful tools in informing strategies to control or eliminate disease. Currently, there is an urgent need to develop these tools to inform policy to achieve the 2020 goals for neglected tropical diseases (NTDs). In this paper we give an overview of a collection of novel model-based analyses which aim to address key questions on the dynamics of transmission and control of nine NTDs: Chagas disease, visceral leishmaniasis, human African trypanosomiasis, leprosy, soil-transmitted helminths, schistosomiasis, lymphatic filariasis, onchocerciasis and trachoma. Several common themes resonate throughout these analyses, including: the importance of epidemiological setting on the success of interventions; targeting groups who are at highest risk of infection or re-infection; and reaching populations who are not accessing interventions and may act as a reservoir for infection,. The results also highlight the challenge of maintaining elimination 'as a public health problem' when true elimination is not reached. The models elucidate the factors that may be contributing most to persistence of disease and discuss the requirements for eventually achieving true elimination, if that is possible. Overall this collection presents new analyses to inform current control initiatives. These papers form a base from which further development of the models and more rigorous validation against a variety of datasets can help to give more detailed advice. At the moment, the models' predictions are being considered as the world prepares for a final push towards control or elimination of neglected tropical diseases by 2020