Expressions of gratitude applied to business: a lesson for managing online reviews

Online reviews are critical for businesses to thrive, but their management is not often effective. Using data from social media platforms, with more than 600 observations of public online interactions between business owners and customers, we showed that strategic management of online reviews predicts a positive increment of online reputation. Publicly expressing gratitude (Study 1) and, specifically, directing these expressions towards beneficial online reviews (Study 2) are effective strategies supporting a general increase of the business online score. These findings identify public expressions of gratitude as a responsive, attentive gesture that signals care and consideration towards customers. Such gesture promotes the online reputation through satisfaction between business community relationships.info:eu-repo/semantics/publishedVersio

The spatial grounding of politics

In three studies, we advance the research on the association between abstract concepts and spatial dimensions by examining the spatial anchoring of political categories in three different paradigms (spatial placement, memory, and classification) and using non-linguistic stimuli (i.e., photos of politicians). The general hypothesis that politicians of a conservative or socialist party are grounded spatially was confirmed across the studies. In Study 1, photos of politicians were spontaneously placed to the left or right of an unanchored horizontal line depending on their socialist-conservative party affiliation. In Study 2, the political orientation of members of parliament systematically distorted the recall of the spatial positions in which they were originally presented. Finally, Study 3 revealed that classification was more accurate and faster when the politicians were presented in spatially congruent positions (e.g., socialist politician presented on the left side of the monitor) rather than incongruent ones (e.g., socialist on the right side). Additionally, we examined whether participants’ political orientation and awareness moderated these effects and showed that spatial anchoring seems independent of political preference but increases with political awareness.Fundação para a Ciência e Tecnologia - FCTinfo:eu-repo/semantics/publishedVersio

Characterization of Salinivibrio socompensis sp. nov., A new halophilic bacterium isolated from the high-altitude hypersaline lake Socompa, Argentina

The genus Salinivibrio belongs to the family Vibrionaceae and includes Gram-stain-negative, motile by a polar flagellum, and facultatively anaerobic curved rods. They are halophilic bacteria commonly found in hypersaline aquatic habitats and salted foods. This genus includes five species and two subspecies. A presumed novel species, strain S35T, was previously isolated from the high-altitude volcanic, alkaline, and saline lake Socompa (Argentinean Andes). In this study we carried out a complete taxonomic characterization of strain S35T, including the 16S rRNA gene sequence and core-genome analysis, the average nucleotide identity (ANIb, ANIm, and orthoANI), and in silico DNA?DNA hybridization (GGDC), as well as the phenotypic and chemotaxonomic characterization. It grew at 3%?20% (w/v) NaCl, pH 6?10, and 10?42 °C, with optimum growth at 7.0%?7.5% (w/v) NaCl, pH 8.0, and 37 °C, respectively. Strain S35T was oxidase- and catalase-positive, able to produce acid from D-glucose and other carbohydrates. Hydrolysis of DNA, methyl red test, and nitrate and nitrite reduction were positive. Its main fatty acids were C16:0, C16:1 ω7c and C16:1 ω6c, and C18:1 ω7c and/or C18:1 ω6c. ANI, GGDC, and core-genome analysis determined that strain S35T constitutes a novel species of the genus Salinivibrio, for which the name Salinivibrio socompensis sp. nov. is proposed. The type strain is S35T (= CECT 9634T = BNM 0535T)Fil: Galisteo, Cristina. Universidad de Sevilla; EspañaFil: Sánchez Porro,Cristina. Universidad de Sevilla; EspañaFil: de la Haba, Rafael R.. Universidad de Sevilla; EspañaFil: López Hermoso, Clara. Universidad de Sevilla; EspañaFil: Fernández, Ana Belén. Universidad de Sevilla; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; ArgentinaFil: Farias, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; ArgentinaFil: Ventosa, Antonio. Department Of Microbiology And Parasitology, Faculty Of; Españ

Phenotype of BTK‐lacking myeloid cells during prolonged COVID‐19 and upon convalescent plasma

© 2022 The Authors. European Journal of Haematology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.XLA patient with 7-month course of COVID-19 with persistent plasma SARS-CoV-2 load revealed a sustained non-inflammatory profile of myeloid cells in association with contained severity of disease, arguing in favor of the use of BTK inhibitors in SARS-COV-2 infection.This work was funded by the following grants from Fundação para a Ciência e a Tecnologia (FCT), Portugal, through “Apoio Especial Research4COVID-19,” project numbers 125 and 803. André M. C. Gomes and Guilherme B. Farias received Fellowships funded by FCT (Doctorates4COVID-19, 2020.10202.BD), and Janssen-Cilag Farmacêutica, respectively.info:eu-repo/semantics/publishedVersio

Ewing's sarcoma: Analysis of single nucleotide polymorphism in the EWS gene

AbstractWe aimed to investigate single nucleotide polymorphisms (SNPs) in the EWS gene breaking region in order to analyze Ewing's sarcoma susceptibility. The SNPs were investigated in a healthy subject population and in Ewing's sarcoma patients from Southern Brazil. Genotyping was performed by TaqMan® assay for allelic discrimination using Real-Time PCR. The analysis of incidence of SNPs or different SNP-arrangements revealed a higher presence of homozygote TT-rs4820804 in Ewing's sarcoma patients (p=0.02; Chi Square Test). About 300bp from the rs4820804 SNP lies a palindromic hexamer (5′-GCTAGC-3′) and three nucleotides (GTC), which were previously identified to be in close vicinity of the breakpoint junction in both EWS and FLI1 genes. This DNA segment surrounding the rs4820804 SNP is likely to indicate a breakpoint region. If the T-rs4820804 allele predisposes a DNA fragment to breakage, homozygotes (TT-rs4820804) would have double the chance of having a chromosome break, increasing the chances for a translocation to occur. In conclusion, the TT-rs4820804 EWS genotype can be associated with Ewing's sarcoma and the SNP rs4820804 can be a candidate marker to understand Ewing's sarcoma susceptibility

Analysis of the compliance of Prescription of High Alert Medication for Onco-hematologic Patients in a Teaching Hospital

requirements of the Protocol for Prescription, Use and Administration of Medicines from Ministry of Health. Method: Cross-sectional study, with prescriptions for onco-hematologic patients in a university teaching unit in the Midwest region of Brazil. The variables were defined as recommended by the Ministry of Health protocol. Data were analyzed using STATA 14.1 software. Results: 57 prescriptions were analyzed and a total of 659 medications were prescribed, of which 20.2% (n=133) were HAM. The most prescribed HAM were tramadol 21.0% (n=28), morphine 19.5% (n=26) and glucose 13.6% (n=18). Regarding non-compliance, 88.0% (n=117) of HAM showed at least one disagreement regarding protocol. Medications prescribed for the central nervous system were the most associated with non-compliance. In all, 266 non-compliance were identified, among which the majority, 18.4% (n=49) were related to the use of vague expressions, 16.2% (n=43) to the absence of infusion time and 11.8% (n=31) the presence of abbreviations. Conclusion: Most HAM prescriptions showed non-compliance regarding Ministry of Health protocol. The main were related to the inappropriate use of vague expressions, omission of infusion time and use of abbreviations. These findings highlight the need to improve the quality of prescriptions and the development of strategies to intercept errors, such as checklists and informational materials

Exosomes derived from mesenchymal stem cells enhance radiotherapy-induced cell death in tumor and metastatic tumor foci

We have recently shown that radiotherapy may not only be a successful local and regional treatment but, when combined with MSCs, may also be a novel systemic cancer therapy. This study aimed to investigate the role of exosomes derived from irradiated MSCs in the delay of tumor growth and metastasis after treatment with MSC + radiotherapy (RT). The tumor cell loss rates found after treatment with the combination of MSC and RT and for exclusive RT, were: 44.4% % and 12,1%, respectively. Concomitant and adjuvant use of RT and MSC, increased the mice surviving time 22,5% in this group, with regard to the group of mice treated with exclusive RT and in a 45,3% respect control group. Moreover, the number of metastatic foci found in the internal organs of the mice treated with MSC + RT was 60% less than the mice group treated with RT alone. We reasoned that the exosome secreted by the MSC, could be implicated in tumor growth delay and metastasis control after treatment. Our results show that exosomes derived form MSCs, combined with radiotherapy, are determinant in the enhancement of radiation effects observed in the control of metastatic spread of melanoma cells and suggest that exosome-derived factors could be involved in the bystander, and abscopal effects found after treatment of the tumors with RT plus MSC. Radiotherapy itself may not be systemic, although it might contribute to a systemic effect when used in combination with mesenchymal stem cells owing the ability of irradiated MSCs-derived exosomes to increase the control of tumor growth and metastasis.This work was supported by CNPq, Conselho Nacional de Desenvolvimento Científico e Tecnológico – Brasil, Junta de Andalucía, project of Excellence from Junta de Andalucía P12-CTS-383 to FJO, Spanish Ministry of Economy and Competitiveness SAF2015-70520-R to FJO and JMRdA, RTICC RD12/0036/0026 and CIBER Cáncer ISCIII CB16/12/00421 to FJO

Rarity of monodominance in hyperdiverse Amazonian forests.

Tropical forests are known for their high diversity. Yet, forest patches do occur in the tropics where a single tree species is dominant. Such "monodominant" forests are known from all of the main tropical regions. For Amazonia, we sampled the occurrence of monodominance in a massive, basin-wide database of forest-inventory plots from the Amazon Tree Diversity Network (ATDN). Utilizing a simple defining metric of at least half of the trees ≥ 10 cm diameter belonging to one species, we found only a few occurrences of monodominance in Amazonia, and the phenomenon was not significantly linked to previously hypothesized life history traits such wood density, seed mass, ectomycorrhizal associations, or Rhizobium nodulation. In our analysis, coppicing (the formation of sprouts at the base of the tree or on roots) was the only trait significantly linked to monodominance. While at specific locales coppicing or ectomycorrhizal associations may confer a considerable advantage to a tree species and lead to its monodominance, very few species have these traits. Mining of the ATDN dataset suggests that monodominance is quite rare in Amazonia, and may be linked primarily to edaphic factors

Inovação e interdisciplinaridade: um estudo de caso no desenvolvimento de competências no curso de engenharia civil

A inovação tecnológica é um processo complexo e o desempenho das organizações depende da sua capacidade de evoluir para se manter com sucesso em mercados cada vez mais globais e competitivos. A interdisciplinaridade é parte fundamental da inovação, porque as modernas soluções dependem da atuação integrada das diversas áreas do conhecimento para que os resultados sejam maximizados. A construção de uma abordagem interdisciplinar é, portanto, fundamental para promover a criação de respostas a quaisquer desafios que possam vir a confrontar as sociedades e organizações. Assim, este trabalho define esses conceitos relevantes e faz uma ligação entre o desenvolvimento de diferentes competências e habilidades de forma interdisciplinar reunindo as bases para um processo de inovação tecnológica e acadêmica orientado à solução de problemas reais, através de ampla pesquisa bibliográfica e valendo-se de um estudo de caso aplicado em uma instituição de ensino superior.  A proposta foi seguir as novas Diretrizes Curriculares Nacionais dos Cursos de Engenharia (DCN) (MEC, 2019a), pela Resolução MEC nº 2, de 24 de abril de 2019 e propor melhorias nas grades do curso de engenharia civil. Adaptando a nova consciência que o curso pode ter 25% da grade EAD (Ensino a Distância) e que a interdisciplinaridade faz parte da inovação

Inovação e interdisciplinaridade: um estudo de caso no desenvolvimento de competências no curso de engenharia civil

A inovação tecnológica é um processo complexo e o desempenho das organizações depende da sua capacidade de evoluir para se manter com sucesso em mercados cada vez mais globais e competitivos. A interdisciplinaridade é parte fundamental da inovação, porque as modernas soluções dependem da atuação integrada das diversas áreas do conhecimento para que os resultados sejam maximizados. A construção de uma abordagem interdisciplinar é, portanto, fundamental para promover a criação de respostas a quaisquer desafios que possam vir a confrontar as sociedades e organizações. Assim, este trabalho define esses conceitos relevantes e faz uma ligação entre o desenvolvimento de diferentes competências e habilidades de forma interdisciplinar reunindo as bases para um processo de inovação tecnológica e acadêmica orientado à solução de problemas reais, através de ampla pesquisa bibliográfica e valendo-se de um estudo de caso aplicado em uma instituição de ensino superior.  A proposta foi seguir as novas Diretrizes Curriculares Nacionais dos Cursos de Engenharia (DCN) (MEC, 2019a), pela Resolução MEC nº 2, de 24 de abril de 2019 e propor melhorias nas grades do curso de engenharia civil. Adaptando a nova consciência que o curso pode ter 25% da grade EAD (Ensino a Distância) e que a interdisciplinaridade faz parte da inovação