Authentic Leadership and Proactive Behavior: The Role of Psychological Capital and Compassion at Work

This study, which is based on survey data provided by 445 employees from a Chinese enterprise, examines the impact of authentic leadership on the proactive behavior of subordinates, in particular the mediating effect of subordinate psychological capital and the moderating effect of compassion at work. The results of our structural equation model reveal that: (1) There is a significant positive correlation between authentic leadership and the proactive behavior of subordinates; (2) psychological capital plays a full mediating role between authentic leadership and subordinate proactive behavior; (3) Compassion at work has a moderating effect on the positive relationship between authentic leadership and subordinate psychological capital and proactive behavior

Authentic Leadership and Proactive Behavior: The Role of Psychological Capital and Compassion at Work

This study, which is based on survey data provided by 445 employees from a Chinese enterprise, examines the impact of authentic leadership on the proactive behavior of subordinates, in particular the mediating effect of subordinate psychological capital and the moderating effect of compassion at work. The results of our structural equation model reveal that: (1) There is a significant positive correlation between authentic leadership and the proactive behavior of subordinates; (2) psychological capital plays a full mediating role between authentic leadership and subordinate proactive behavior; (3) Compassion at work has a moderating effect on the positive relationship between authentic leadership and subordinate psychological capital and proactive behavior

Investigating the attentional bias and information processing mechanism of mobile phone addicts towards emotional information

Mobile phone addiction is a behavioral addiction that leads to physical and psychological maladaptation. Researchers have focused on the attentional bias of cognitive cues while neglecting the role of emotional information. The main debate concerning emotional information has been on whether its associated attentional bias is caused by different types of emotional information or only by negative emotional information. We investigated the specific information processing mechanism that lies behind mobile phone addicts’ attentional bias towards emotional information. In this study, behavioral experiments were performed using the dot-probe paradigm. The results showed that high-level mobile phone addicts (MPAs) have attentional bias towards negative emotional information. In order to understand the mechanism of attentional bias more precisely, a follow up study was carried out using eye movement techniques. The results of this follow up study found that, compared with the normal use group, high-level MPAs’ eyes tended to fixate first on negative faces, and significantly more on negative faces than on positive faces. When high-level MPAs demonstrated attentional bias towards negative faces, their first fixation duration was significantly longer than those for positive faces. However, there was no overall attention maintenance of negative emotional information. We conclude that mobile phone addicts have attentional bias towards negative emotional information, manifested as an alert-maintenance model, meaning that attention orientation and difficult disengagement function together. The results of this study could be used to guide interventions geared towards attentional bias training for mobile phone addicts, as well as providing theoretical support for treatment and intervention

Identifying a locus in super-enhancer and its resident NFE2L1/MAFG as transcriptional factors that drive PD-L1 expression and immune evasion

Abstract Although the transcriptional regulation of the programmed death ligand 1 (PD-L1) promoter has been extensively studied, the transcription factor residing in the PD-L1 super-enhancer has not been comprehensively explored. Through saturated CRISPR-Cas9 screening of the core region of the PD-L1 super-enhancer, we have identified a crucial genetic locus, referred to as locus 22, which is essential for PD-L1 expression. Locus 22 is a potential binding site for NFE2:MAF transcription factors. Although genetic silencing of NRF2 (NFE2L2) did not result in a reduction of PD-L1 expression, further analysis reveals that MAFG and NFE2L1 (NRF1) play a critical role in the expression of PD-L1. Importantly, lipopolysaccharides (LPS) as the major component of intratumoral bacteria could greatly induce PD-L1 expression, which is dependent on the PD-L1 super-enhancer, locus 22, and NFE2L1/MAFG. Mechanistically, genetic modification of locus 22 and silencing of MAFG greatly reduce BRD4 binding and loop formation but have minimal effects on H3K27Ac modification. Unlike control cells, cells with genetic modification of locus 22 and silencing of NFE2L1/MAFG failed to escape T cell-mediated killing. In breast cancer, the expression of MAFG is positively correlated with the expression of PD-L1. Taken together, our findings demonstrate the critical role of locus 22 and its associated transcription factor NFE2L1/MAFG in super-enhancer– and LPS-induced PD-L1 expression. Our findings provide new insight into understanding the regulation of PD-L1 transcription and intratumoral bacteria-mediated immune evasion