"Anti-Christ" A "Screen pageant", in twelve scenes

Thesis (M.A.)--Boston University, 1946. This item was digitized by the Internet Archive

Annual Periodicity of the 18O16O and 13C12C ratios in the coral Montastrea annularis

The isotopic ratios 18O/16O and 13C/12C show an annual periodicity in the coral Montastrea annularis from Bermuda, Jamaica and Barbados. The abundances of 18O and 13C are positively correlated in the Jamaica and Barbados samples, but inversely related in the Bermuda sample. Annual high density growth bands are formed during the season of warmest water temperature at all 3 sites and are enriched in 16O. M. Annularis has a constant displacement from oxygen isotopic equilibrium and accurately records seasonal temperature variations via the temperature-dependent aragonite-water fractionation factor. Light intensity, through the activity of the coral\u27s endosymbiotic algae, regulates the depth-dependent and seasonal variations in the skeletal carbon isotopic composition

Freshwater balance and the sources of deep and bottom waters in the Arctic Ocean inferred from the distribution of H218O

Data from sections across the Eurasian Basin of the Arctic Ocean occupied in 1987 and 1991 are used to derive information on the freshwater balance of the Arctic Ocean and on sources of the deep waters of the Nansen, Amundsen and Makarov basins. Using salinity, H218O, and mass balances we estimate the river-runoff and the sea-ice melt water fractions contained in the upper waters of the Arctic Ocean and infer pathways of the river-runoff signal from the shelf seas across the central Arctic Ocean to Fram Strait. The average mean residence time of the river-runoff fraction contained in the Arctic Ocean halocline is determined to be about 11 to 14 years. Pacific water entering through Bering Strait is traced using silicate and its influence on the halocline waters of the Canadian Basin is estimated. Water column inventories of river-runoff and sea-ice melt water are calculated for a section just north of Fram Strait and implications of these inventories for sea-ice export through Fram Strait are discussed. Comparison of the ratios of shelf water, Atlantic water and the deep waters of the Arctic Ocean indicate that the sources of the deep and bottom waters of the Eurasian Basin are located in the Barents and Kara seas

The influence of air-sea exchange on the isotopic composition of oceanic carbon: Observations and modeling

Although the carbon isotopic composition of ocean waters after they leave the surface ocean is determined by biological cycling, air-sea exchange affects the carbon isotopic composition of surface waters in two ways. The equilibrium fractionation between oceanic and atmospheric carbon increases with decreasing temperature. In Southern Ocean Surface Waters this isotopic equilibration enriches δ13C relative to the δ13C expected from uptake and release of carbon by biological processes alone. Similarly, surface waters in the subtropical gyres are depleted in δ13C due to extensive air-sea exchange at warm temperatures. Countering the tendency toward isotopic equilibration with the atmosphere (a relatively slow process), are the effects of the equilibration of CO2 itself (a much faster process). In regions where there is a net transfer of isotopically light CO2 from the ocean to the atmosphere (e.g., the equator) surface waters become enriched in 13C, whereas in regions where isotopically light CO2 is entering the ocean (e.g., the North Atlantic) surface waters become depleted in 13C. A compilation of high quality oceanic δ13C measurements along with experiments performed using a zonally averaged three-basin dynamic ocean model are used to explore these processes

Metabolite and thymocyte development defects in ADA-SCID mice receiving enzyme replacement therapy

Deficiency of adenosine deaminase (ADA, EC3.5.4.4), a housekeeping enzyme intrinsic to the purine salvage pathway, leads to severe combined immunodeficiency (SCID) both in humans and mice. Lack of ADA results in the intracellular accumulation of toxic metabolites which have effects on T cell development and function. While untreated ADA-SCID is a fatal disorder, there are different therapeutic options available to restore ADA activity and reconstitute a functioning immune system, including enzyme replacement therapy (ERT). Administration of ERT in the form of pegylated bovine ADA (PEG-ADA) has proved a life-saving though non-curative treatment for ADA-SCID patients. However, in many patients treated with PEG-ADA, there is suboptimal immune recovery with low T and B cell numbers. Here, we show reduced thymus cellularity in ADA-SCID mice despite weekly PEG-ADA treatment. This was associated with lack of effective adenosine (Ado) detoxification in the thymus. We also show that thymocyte development in ADA-deficient thymi is arrested at the DN3-to-DN4 stage transition with thymocytes undergoing dATP-induced apoptosis rather than defective TCRβ rearrangement or β-selection. Our studies demonstrate at a detailed level that exogenous once-a-week enzyme replacement does not fully correct intra-thymic metabolic or immunological abnormalities associated with ADA deficiency

Electrospinning of 2-hydroxypropyl-β-cyclodextrin aqueous solutions with added salts

It has been proposed that hydrogen bonding plays a role in promoting the electrospinnability of some materials. In this study, the role of non-covalent interactions in the electrospinnability of 2-hydroxypropyl-β-cyclodextrin (2HP-β-CD) was investigated by varying the physical-chemical properties the solvents. The rheological behaviour of a peroxide-aqueous/acetone-ethanol/NaHCO3 solution and an aqueous urea solution, as a function of aqueous 2HP-β-CD concentration, was compared. The rheological behaviour of 2HP-β-CD solutions was characterized by a frequency-independent stress relaxation plateau such as that observed in cross-linked polymer networks and reversible polymer gels with non-linear viscoelasticity. We conclude that the electrospinnability of 2HP-β-CD is, as evidenced by the changes in the morphology of the electrospun 2HP-β-CD materials, in agreement with other related studies on the electrospinning of Cyclodextrins. Also, the electrospinnability of 2HP-β-CD does appear to be related to the physical-chemical properties of the solvent systems

Metabolite and thymocyte development defects in ADA-SCID mice receiving enzyme replacement therapy

Deficiency of adenosine deaminase (ADA, EC3.5.4.4), a housekeeping enzyme intrinsic to the purine salvage pathway, leads to severe combined immunodeficiency (SCID) both in humans and mice. Lack of ADA results in the intracellular accumulation of toxic metabolites which have effects on T cell development and function. While untreated ADA-SCID is a fatal disorder, there are different therapeutic options available to restore ADA activity and reconstitute a functioning immune system, including enzyme replacement therapy (ERT). Administration of ERT in the form of pegylated bovine ADA (PEG-ADA) has proved a life-saving though non-curative treatment for ADA-SCID patients. However, in many patients treated with PEG-ADA, there is suboptimal immune recovery with low T and B cell numbers. Here, we show reduced thymus cellularity in ADA-SCID mice despite weekly PEG-ADA treatment. This was associated with lack of effective adenosine (Ado) detoxification in the thymus. We also show that thymocyte development in ADA-deficient thymi is arrested at the DN3-to-DN4 stage transition with thymocytes undergoing dATP-induced apoptosis rather than defective TCRβ rearrangement or β-selection. Our studies demonstrate at a detailed level that exogenous once-a-week enzyme replacement does not fully correct intra-thymic metabolic or immunological abnormalities associated with ADA deficiency