Anaphylaxis after zoster vaccine: Implicating alpha-gal allergy as a possible mechanism

Letter to the edito

Reactivity to heparin in patients with alpha-gal allergy

Galactose-alpha-1,3-galactose (alpha-gal) syndrome is an immunoglobulin (Ig)E-mediated allergy syndrome to an oligosaccharide found in nonprimate mammalian meat and mammalian-derived products. 1 Oral consumption reactions are characteristically delayed, but are immediate with parenteral administration. 1 Since the discovery of alpha-gal IgE antibodies while investigating hypersensitivity reactions to cetuximab, much attention has been paid to both theoretical risks and reported cases of hypersensitivity reactions to various medications and medical devices derived from nonprimate mammals. 1 ,2 The true extent of this risk is still largely unknown. 3 One medication of interest is heparin; both unfractionated heparin and low-molecular weight heparin, enoxaparin, are derived from porcine intestinal tissue. In a case of immediate hypersensitivity to heparin in a patient with a high concentration of alpha-gal–specific IgE (sIgE), we would like to draw attention to positive skin testing result to heparin products

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Letter to the Edito

Effects of sorghum particle size on milling characteristics, growth performance, and carcass characteristics in finishing pigs

A total of 200 finishing pigs (PIC TR4 × 1050; average initial BW of 103.2 lb) were used in a 69-d growth assay to determine the effects of sorghum particle size on growth performance. Pigs were sorted by sex and ancestry and balanced by BW, with 5 pigs per pen and 10 pens per treatment. Treatments were a corn-soybean meal-based control with the corn milled to a target mean particle size of 600 μm, and sorghum diets milled to a target mean particle size of 800, 600, or 400 μm. Actual mean particle sizes were 555 μm for corn, and 724, 573, and 319 μm for sorghum, respectively. Feed and water were offered on an ad libitum basis until the pigs were slaughtered (average final BW of 271 lb) at a commercial abattoir. Reducing sorghum particle size improved (linear, P < 0.01) F/G, and we observed a tendency for decreased (P < 0.06) ADFI. Reducing sorghum particle size from 724 to 319 μm had no effects on HCW, backfat thickness, loin depth, or percentage fat-free lean index (FFLI), but tended to increase (P < 0.06) carcass yield. Pigs fed the sorghum-based diets had no difference in growth performance or carcass characteristics compared with those fed the control diet, except carcass yield, which was numerically greater (P < 0.07) for pigs fed the sorghum-based diets. When using a regression equation, we determined that sorghum must be ground to 513 μm to achieve a F/G equal to that of a corn-based diet, with corn ground to 550 μm. In conclusion, linear improvements in F/G and carcass yield were demonstrated with the reduction of sorghum particle size to 319 μm. In this experiment, sorghum should be ground 42 μm finer than corn to achieve a similar feeding value

Effects of adding cracked corn to a pelleted supplement for nursery and finishing pigs

Three experiments were conducted to determine the effects of supplementing cracked corn into diets of nursery and finishing pigs. In Exp. 1, 144 pigs were used in a 28-d trial. Pigs (PIC TR4 × 1050; initially 16.5 lb) were weaned and allotted with 6 pigs per pen (3 barrows and 3 gilts) and 6 pens per treatment. All pigs were fed a common diet for 7 d postweaning and the experimental diets for the next 28 d. Treatments were corn-soybean meal-based in the form of mash, pellets, and pellets with 100% of the corn either ground (618 μm) or cracked (3,444 μm) and blended into the diet after the rest of the formulation (the supplement) had been pelleted. Overall (d 0 to 28), ADG and F/G improved when pigs were fed the mash control compared to the pelleted diets (P < 0.001); however, this response was caused by the poor performance of pigs fed the supplement treatments, with the pigs fed the complete pellets having improved (P < 0.01) ADG and F/G compared with pigs fed the pelleted supplement blended with ground and cracked corn. Finally, pigs fed the supplement blended with cracked corn had numerically lower (P < 0.11) ADG and poorer (P < 0.001) F/G compared to those fed the supplement blended with ground corn. In Exp. 2, 224 nursery pigs (initially 16.3 lb) were used with 7 barrows or 7 gilts per pen and 8 pens per treatment. Treatments were corn-soybean meal-based and fed as mash, pellets, and pellets with 50% of the corn either ground (445 μm) or cracked (2,142 μm) and blended with the pelleted supplement. Pigs fed mash had improved (P < 0.03) ADG and F/G compared with pigs fed the other treatments; however, this resulted from adding ground or cracked corn outside the pellets (complete pellets vs. pelleted supplement with corn, P < 0.01). In Exp. 3, 252 finishing pigs (initially 88.2 lb) were used with 7 pigs per pen and 9 pens per treatment. The treatments were the same as Exp. 2. Pigs fed mash had lower (P < 0.004) ADG compared with pigs fed diets with pellets. Pigs fed complete pellets had improved (P < 0.03) ADG and F/G compared with pigs fed corn and the pelleted supplement. Also, pigs fed the supplement blended with cracked corn had greater (P < 0.02) ADG than pigs fed the supplement blended with ground corn. Pelleting the diet led to an increase (P < 0.05) in ulceration scores; however, these negative effects on ulcer scores were reduced (P < 0.001) by cracking 50% of the corn and adding it postpellet