From Mayfair to Mecca Lady Evelyn Cobbold’s pilgrimage in 1933

British Academ

Implementing Internationalization in Ontario in a Public-Private Partnership

Abstract The goal of Canada’s International Education Strategy: Harnessing our Knowledge Advantage to Drive Innovation and Prosperity (Global Affairs Canada, 2014) is to target the best and brightest international students to study in the country’s higher education institutions, mutually benefiting the student and the country’s economy. However, internationalization has created a new reality, with students graduating ill-equipped for the global society and a demand for approaches that embrace the complexities of diversity and changing environments (Dailey-Hebert & Dennis, 2015). Absent from the internationalization agenda are the considerations of impact on students and what they need in an organization’s culture to be most successful in their “abroad” learning. Evaluation of how internationalization is implemented is a gap and missing from the internationalization discourse is how faculty and staff can be equipped in their roles as implementers of internationalization. Change is needed in higher education institutions, and it requires leadership and an awareness of the organization’s culture and context. The Problem of Practice (POP) in this Organizational Improvement Plan (OIP) is the lack of an organizational culture focus in supporting international students in an Ontario higher education institution. Using the experience of a partnership between a public community college and a private for-profit college, this OIP will outline a proposal for a change plan for the public-private partnership to develop a culturally competent organizational culture. This OIP will also be framed by the distributed leadership approach, the organized anarchy perspective, and the competing values framework to understand the organization and facilitate the change. Keywords: Competing Values Framework, Distributed Leadership, Internationalization, Organized Anarchy, Organizational Culture, Public-private Partnershi

Alpha-SYNUCLEINOPATHY reduces NMNAT3 protein levels and neurite formation that can be rescued by targeting the NAD+ pathway

Parkinson’s disease is characterised by the deposition of α-synuclein, which leads to synaptic dysfunction, the loss of neuronal connections and ultimately progressive neurodegeneration. Despite extensive research into Parkinson’s disease pathogenesis, the mechanisms underlying α-synuclein mediated synaptopathy have remained elusive. Several lines of evidence suggest that altered NAD+ metabolism might be causally related to synucleinopathies, including Parkinson’s disease. NAD+ metabolism is central to the maintenance of synaptic structure and function. Its synthesis is mediated by nicotinamide mononucleotide adenylyltransferases (NMNATs), but their role in Parkinson’s disease is not known. Here we report significantly decreased levels of NMNAT3 protein in the caudate nucleus of patients who have died with Parkinson’s disease which inversely correlated with the amount of monomeric α-synuclein. The detected alterations were specific and significant as the expression levels of NMNAT1, NMNAT2 and sterile alpha and TIR motif containing 1 were not significantly different in Parkinson’s disease subjects compared to controls. To test the functional significance of these findings, we ectopically expressed wild-type α-synuclein in retinoic acid-differentiated dopaminergic SH-SY5Y cells which resulted in decreased levels of NMNAT3 protein plus a neurite pathology which could be rescued by FK866, an inhibitor of nicotinamide phosphoribosyltransferase that acts as a key enzyme in the regulation of NAD+ synthesis. Our results establish, for the first time, NMNAT3 alterations in Parkinson’s disease and demonstrate in human cells that this phenotype together with neurite pathology is causally related to α-synucleinopathy. These findings identify alterations in the NAD+ biosynthetic pathway as a pathogenic mechanism underlying α-synuclein mediated synaptopathy

An audiovisual program for the Pioneer Valley Regional School and elementary schools of Union #18.

Thesis (M.Ed.

The development of a 14-18 physical education curriculum in a community setting

This study set out to produce a working document for teachers and headteachers in Coventry schools. This working document was written to offer guidelines for physical education departments in the design and implementation of their own curriculum and to raise their awareness of the role that physical education can perform in schools. It details recent trends and issues in the community and describes in particular the philosophy of Coventry Education Authority. This philosophy is reflected in the L.E.A. document 'Comprehensive Education for Life' (Coventry 1982), and the working document responds to this publication, in particular, to its commitment to life-long education and the pursuit of active-learning styles. The implications these local and national trends have for physical education departments were examined and detailed in the working document. Twenty-five interviews were recorded on tape and provided a data ·base for analysis. Themes were drawn from these interviews and it was possible to articulate major lines of development that key people in the profession were identifying. Drawing upon the evolutionary development of the document, interviews and seminars with key people in the field, it was possible to identify major aspects of work that· ought to be developed in physical education if the profession was going to translate important aspirations into a guide for action. The study helped to evolve a framework which describes a direction for the physical education curriculum and also what it can sample and focus upon. By recording this development in the working document, physical education departments were then encouraged to explore this framework and from using examples of current practice described in the document, developed their own programmes. Finally the working document presents a collection of teaching and learning processes in current practice which help the teaching of physical education focus upon the individual's personal development. Throughout the document, suggestions for evaluating the curriculum, teaching and learning are proposed, and physical education departments are challenged to review their curriculum

Large space telescope engineering scale model optical design

The objective is to develop the detailed design and tolerance data for the LST engineering scale model optical system. This will enable MSFC to move forward to the optical element procurement phase and also to evaluate tolerances, manufacturing requirements, assembly/checkout procedures, reliability, operational complexity, stability requirements of the structure and thermal system, and the flexibility to change and grow

Structural Analysis of the Japanese Language Using Montague Grammar.

This thesis applies Montague's theory of grammar to a fragment of ordinary Japanese and aims to provide a foundation for an explicit semantics of Japanese. The typological or transformational studies will be presented first as data and the corresponding Montague grammatical analyses will be proposed. In Chapter 1, Montague's theory of grammar is discussed, comparisons being made with Davidsonian truth conditional semantics and Chomskyan transformational grammar. In Chapter 2, subjects, adjectives and adverbs are analysed, in Chapter 3, complementation, in Chapter 4 reflexives, passives, causatives, and in Chapter 5 negation and factive presupposition. The main theoretical concern is the relation between a logical syntax and linguistic syntax. It is hoped that a new linguistic framework will be developed from this study. The other important theoretical concern is the relation between semantics and pragmatics