FTIR imaging in diffusion studies: CO2 and H2O in a synthetic sector-zoned beryl

In this work we investigate the strongly inhomogeneous distribution of CO2 and H2O in a synthetic beryl having a peculiar hourglass zoning of Cr due to the crystal growth. The sample was treated at 800°C, 500 MPa, in a CO2-rich atmosphere. High-resolution FESEM images revealed that the hourglass boundary is not correlated to physical discontinuities, at least at the scale of tens of nanometers. Polarized FPA-FTIR imaging, on the other side, revealed that the chemical zoning acts as a fast pathway for carbon dioxide diffusion, a feature never observed so far in minerals. The hourglass zone boundary may be thus considered as a structural defect possibly due to the mismatch induced by the different growth rates of each sector. High-resolution synchrotron-light FTIR imaging, in addition, also allows enhancement of CO2 diffusion along the hourglass boundary to be distinguished from diffusion along fractures in the grain. Therefore, FTIR imaging provides evidence that different diffusion mechanisms may locally combine, suggesting that the distribution of the target molecules needs to be carefully characterized in experimental studies. This piece of information is mandatory when the study is aimed at extracting diffusion coefficients from analytical profiles. Combination of TOF-SIMS and FPA data shows a significant depletion of type II H2O along the hourglass boundary, indicating that water diffusion could be controlled by the distribution of alkali cations within channels, coupled to a plug effect of CO2. © 2015 Della Ventura, Radica, Bellatreccia, Cavallo, Cinque, Tortora and Behrens

Production of lead metal by molten-salt electrolysis with energy-efficient electrodes

"The U.S. Bureau of Mines investigated electrode designs for electrowinning lead metal from a LiCl-KCl-PbCl2 electrolyte at 450 deg C. The major objective of this investigation was to decrease the energy requirement for lead electrowinning. Electrolysis was performed in a bench-scale cell using several graphite electrode assemblies. Such parameters as electrode spacing, current density, and chlorine gas removal from the anode were investigated in the bench-scale tests. An optimum electrode assembly, termed the sawtooth design, was scaled up and operated at 3,000 and 4,000 A. The sawtooth electrodes operating at 3,000 A produced lead for 0.66 Kw.H/kg. The electrodes were constructed by cutting large triangular grooves in the electrode surfaces. The electrodes were placed together such that the triangular peaks of one electrode projected into the triangular valleys of the other electrode. Chlorine did not build up on the anode with the sawtooth electrodes." - NIOSHTIC-2NIOSHTIC no. 10008548199

SEAGLE--II: Constraints on feedback models in galaxy formation from massive early type strong lens galaxies

We use nine different galaxy formation scenarios in ten cosmological simulation boxes from the EAGLE suite of {\Lambda}CDM hydrodynamical simulations to assess the impact of feedback mechanisms in galaxy formation and compare these to observed strong gravitational lenses. To compare observations with simulations, we create strong lenses with $M_\star$ > $10^{11}$ $M_\odot$ with the appropriate resolution and noise level, and model them with an elliptical power-law mass model to constrain their total mass density slope. We also obtain the mass-size relation of the simulated lens-galaxy sample. We find significant variation in the total mass density slope at the Einstein radius and in the projected stellar mass-size relation, mainly due to different implementations of stellar and AGN feedback. We find that for lens selected galaxies, models with either too weak or too strong stellar and/or AGN feedback fail to explain the distribution of observed mass-density slopes, with the counter-intuitive trend that increasing the feedback steepens the mass density slope around the Einstein radius ($\approx$ 3-10 kpc). Models in which stellar feedback becomes inefficient at high gas densities, or weaker AGN feedback with a higher duty cycle, produce strong lenses with total mass density slopes close to isothermal (i.e. -d log({\rho})/d log(r) $\approx$ 2.0) and slope distributions statistically agreeing with observed strong lens galaxies in SLACS and BELLS. Agreement is only slightly worse with the more heterogeneous SL2S lens galaxy sample. Observations of strong-lens selected galaxies thus appear to favor models with relatively weak feedback in massive galaxies.Comment: re-submitted to MNRAS, bug fixed, conclusions unchanged, updated appendices and references, 23 pages, 10 Figures, 6 Table

The role of inferior petrosal sinus sampling in ACTH-dependent Cushing's syndrome: review and joint opinion statement by members of the Italian Society for Endocrinology, Italian Society for Neurosurgery, and Italian Society for Neuroradiology

In the management of adrenocorticotropic hormone (ACTH)-dependent Cushing's syndrome, inferior petrosal sinus sampling (IPSS) provides information for the endocrinologist, the neurosurgeon, and the neuroradiologist. To the endocrinologist who performs the etiological diagnosis, results of IPSS confirm or exclude the diagnosis of Cushing's disease with 80%-100% sensitivity and over 95% specificity. Baseline central-peripheral gradients have suboptimal accuracy, and stimulation with corticotropin-releasing hormone (CRH), possibly desmopressin, has to be performed. The rationale for the use of IPSS in this context depends on other diagnostic means, taking availability of CRH and reliability of dynamic testing and pituitary imaging into account. As regards the other specialists, the neuroradiologist may collate results of IPSS with findings at imaging, while IPSS may prove useful to the neurosurgeon to chart a surgical course. The present review illustrates the current standpoint of these 3 specialists on the role of IPSS

Targeting the Diuretic Hormone Receptor to Control the Cotton Leafworm,<i>Spodoptera littoralis</i>

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Pituitary function and morphology in Fabry disease.

Endocrine abnormalities are known to affect patients with Fabry disease (FD). Pituitary gland theoretically represents an ideal target for FD because of high vascularization and low proliferation rate. We explored pituitary morphology and function in a cohort of FD patients through a prospectic, monocentric study at an Academic Tertiary Center. The study population included 28 FD patients and 42 sex and age-matched normal subjects. The protocol included a contrast enhancement pituitary MRI, the assessment of pituitary hormones, anti-pituitary, and anti-hypothalamus antibodies. At pituitary MRI, an empty sella was found in 11 (39%) FD patients, and in 2 (5%) controls (p < 0.001). Pituitary volume was significantly smaller in FD than in controls (p < 0.001). Determinants of pituitary volume were age and alpha-galactosidase enzyme activity. Both parameters resulted independently correlated at multivariate analysis. Pituitary function was substantially preserved in FD patients. Empty sella is a common finding in patients with FD. The major prevalence in the elderly supports the hypothesis of a progressive pituitary shrinkage overtime. Pituitary function seems not to be impaired in FD. An endocrine workup with pituitary hormone assessment should be periodically performed in FD patients, who are already at risk of cardiovascular complications

AMICO galaxy clusters in KiDS-DR3: galaxy population properties and their redshift dependence

A catalogue of galaxy clusters was obtained in an area of 414 sq deg up to a redshift $z\sim0.8$ from the Data Release 3 of the Kilo-Degree Survey (KiDS-DR3), using the Adaptive Matched Identifier of Clustered Objects (AMICO) algorithm. The catalogue and the calibration of the richness-mass relation were presented in two companion papers. Here we describe the selection of the cluster central galaxy and the classification of blue and red cluster members, and analyze the main cluster properties, such as the red/blue fraction, cluster mass, brightness and stellar mass of the central galaxy, and their dependence on redshift and cluster richness. We use the Illustris-TNG simulation, which represents the state-of-the-art cosmological simulation of galaxy formation, as a benchmark for the interpretation of the results. A good agreement with simulations is found at low redshifts ($z \le 0.4$), while at higher redshifts the simulations indicate a lower fraction of blue galaxies than what found in the KiDS-AMICO catalogue: we argue that this may be due to an underestimate of star-forming galaxies in the simulations. The selection of clusters with a larger magnitude difference between the two brightest central galaxies, which may indicate a more relaxed cluster dynamical status, improves the agreement between the observed and simulated cluster mass and stellar mass of the central galaxy. We also find that at a given cluster mass the stellar mass of blue central galaxies is lower than that of the red ones.Comment: 14 pages, 16 figures, accepted for publication on MNRA

Clinical correlates of R1 relaxometry and magnetic susceptibility changes in multiple sclerosis: a multi-parameter quantitative MRI study of brain iron and myelin

Objectives: The clinical impact of brain microstructural abnormalities in multiple sclerosis (MS) remains elusive. We aimed to characterize the topography of longitudinal relaxation rate (R1) and quantitative susceptibility (χ) changes, as indices of iron and myelin, together with brain atrophy, and to clarify their contribution to cognitive and motor disability in MS. Methods: In this cross-sectional study, voxel-based morphometry, and voxel-based quantification analyses of R1 and χ maps were conducted in gray matter (GM) and white matter (WM) of 117 MS patients and 53 healthy controls. Voxel-wise between-group differences were assessed with nonparametric permutation tests, while correlations between MRI metrics and clinical variables (global disability, cognitive and motor performance) were assessed both globally and voxel-wise within clusters emerging from the between-group comparisons. Results: MS patients showed widespread R1 decrease associated with more limited modifications of χ, with atrophy mainly involving deep GM, posterior and infratentorial regions (p < 0.02). While R1 and χ showed a parallel reduction in several WM tracts (p < 0.001), reduced GM R1 values (p < 0.001) were associated with decreased thalamic χ (p < 0.001) and small clusters of increased χ in the caudate nucleus and prefrontal cortex (p < 0.02). In addition to the atrophy, χ values in the cingulum and corona radiata correlated with global disability and motor performance, while focal demyelination correlated with cognitive performance (p < 0.04). Conclusions: We confirmed the presence of widespread R1 changes, involving both GM and WM, and atrophy in MS, with less extensive modifications of tissue χ. While atrophy and χ changes are related to global and motor disability, R1 changes are meaningful correlates of cognition. Key points: • Compared to healthy controls, multiple sclerosis patients showed R1 and χ changes suggestive of iron increase within the basal ganglia and reduced iron and myelin content within (subnuclei of) the thalamus. • Thalamic volume and χ changes significantly predicted clinical disability, as well as pulvinar R1 and χ changes, independently from atrophy. • Atrophy-independent R1 and χ changes, suggestive of thalamic iron and myelin depletion, may represent a sensitive marker of subclinical inflammation

Impact of the Pattern of Atrial Fibrillation on Stroke Risk and Mortality

Thromboembolism is the most serious complication of AF, and oral anticoagulation is the mainstay therapy. Current guidelines place all AF types together in terms of anticoagulation with the major determinants being associated comorbidities translated into risk marker. Among patients in large clinical trials, those with non-paroxysmal AF appear to be at higher risk of stroke than those with paroxysmal AF. Higher complexity of the AF pattern is also associated with higher risk of mortality. Moreover, continuous monitoring of AF through cardiac implantable devices provided us with the concept of ‘AF burden’. Usually, the larger the AF burden, the higher the risk of stroke; however, the relationship is not well characterised with respect to the threshold value above which the risk increases. The picture is more complex than it appears: AF and underlying disorders must act synergically respecting the magnitude of its own characteristics, which are the amount of time a patient stays in AF and the severity of associated comorbidities

Transcript Regulation of the Recoded Archaeal α-L-Fucosidase In Vivo

Genetic decoding is flexible, due to programmed deviation of the ribosomes from standard translational rules, globally termed “recoding”. In Archaea, recoding has been unequivocally determined only for termination codon readthrough events that regulate the incorporation of the unusual amino acids selenocysteine and pyrrolysine, and for −1 programmed frameshifting that allow the expression of a fully functional α-l-fucosidase in the crenarchaeon Saccharolobus solfataricus, in which several functional interrupted genes have been identified. Increasing evidence suggests that the flexibility of the genetic code decoding could provide an evolutionary advantage in extreme conditions, therefore, the identification and study of interrupted genes in extremophilic Archaea could be important from an astrobiological point of view, providing new information on the origin and evolution of the genetic code and on the limits of life on Earth. In order to shed some light on the mechanism of programmed −1 frameshifting in Archaea, here we report, for the first time, on the analysis of the transcription of this recoded archaeal α-l-fucosidase and of its full-length mutant in different growth conditions in vivo. We found that only the wild type mRNA significantly increased in S. solfataricus after cold shock and in cells grown in minimal medium containing hydrolyzed xyloglucan as carbon source. Our results indicated that the increased level of fucA mRNA cannot be explained by transcript up-regulation alone. A different mechanism related to translation efficiency is discusse