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Effective elements of cognitive behaviour therapy for psychosis: results of a novel type of subgroup analysis based on principal stratification
Background. Meta-analyses show that cognitive behaviour therapy for psychosis (CBT-P) improves distressing positive symptoms. However, it is a complex intervention involving a range of techniques. No previous study has assessed the delivery of the different elements of treatment and their effect on outcome. Our aim was to assess the differential effect of type of treatment delivered on the effectiveness of CBT-P, using novel statistical methodology.
Method. The Psychological Prevention of Relapse in Psychosis (PRP) trial was a multi-centre randomized controlled trial (RCT) that compared CBT-P with treatment as usual (TAU). Therapy was manualized, and detailed evaluations of therapy delivery and client engagement were made. Follow-up assessments were made at 12 and 24 months. In a planned analysis, we applied principal stratification (involving structural equation modelling with finite mixtures) to estimate intention-to-treat (ITT) effects for subgroups of participants, defined by qualitative and quantitative differences in receipt of therapy, while maintaining the constraints of randomization.
Results. Consistent delivery of full therapy, including specific cognitive and behavioural techniques, was associated with clinically and statistically significant increases in months in remission, and decreases in psychotic and affective symptoms. Delivery of partial therapy involving engagement and assessment was not effective.
Conclusions. Our analyses suggest that CBT-P is of significant benefit on multiple outcomes to patients able to engage in the full range of therapy procedures. The novel statistical methods illustrated in this report have general application to the evaluation of heterogeneity in the effects of treatment
Towards practical classical processing for the surface code
The surface code is unarguably the leading quantum error correction code for
2-D nearest neighbor architectures, featuring a high threshold error rate of
approximately 1%, low overhead implementations of the entire Clifford group,
and flexible, arbitrarily long-range logical gates. These highly desirable
features come at the cost of significant classical processing complexity. We
show how to perform the processing associated with an nxn lattice of qubits,
each being manipulated in a realistic, fault-tolerant manner, in O(n^2) average
time per round of error correction. We also describe how to parallelize the
algorithm to achieve O(1) average processing per round, using only constant
computing resources per unit area and local communication. Both of these
complexities are optimal.Comment: 5 pages, 6 figures, published version with some additional tex
Gene identification for the cblD defect of vitamin B12 metabolism
Background Vitamin B12 (cobalamin) is an essential cofactor in several metabolic pathways. Intracellular conversion of cobalamin to its two coenzymes, adenosylcobalamin in mitochondria and methylcobalamin in the cytoplasm, is necessary for the homeostasis of methylmalonic acid and homocysteine. Nine defects of intracellular cobalamin metabolism have been defined by means of somatic complementation analysis. One of these defects, the cblD defect, can cause isolated methylmalonic aciduria, isolated homocystinuria, or both. Affected persons present with multisystem clinical abnormalities, including developmental, hematologic, neurologic, and metabolic findings. The gene responsible for the cblD defect has not been identified.
Methods We studied seven patients with the cblD defect, and skin fibroblasts from each were investigated in cell culture. Microcell-mediated chromosome transfer and refined genetic mapping were used to localize the responsible gene. This gene was transfected into cblD fibroblasts to test for the rescue of adenosylcobalamin and methylcobalamin synthesis.
Results The cblD gene was localized to human chromosome 2q23.2, and a candidate gene, designated MMADHC (methylmalonic aciduria, cblD type, and homocystinuria), was identified in this region. Transfection of wild-type MMADHC rescued the cellular phenotype, and the functional importance of mutant alleles was shown by means of transfection with mutant constructs. The predicted MMADHC protein has sequence homology with a bacterial ATP-binding cassette transporter and contains a putative cobalamin binding motif and a putative mitochondrial targeting sequence.
Conclusions Mutations in a gene we designated MMADHC are responsible for the cblD defect in vitamin B12 metabolism. Various mutations are associated with each of the three biochemical phenotypes of the disorder
Exact Results of the 1D Supersymmetric t-J Model without Translational Invariance
In this work, we continue the study of the supersymmetric t-J model with
1/r^2 hopping and exchange without translational invariance. A set of Jastrow
wavefunctions are obtained for the system, with eigenenergies explicitly
calculated. The ground state of the t-J model is included in this set of
wavefunctions. The spectrum of this t-J model consists of equal-distant energy
levels which are highly degenerate.Comment: 14 pages, Late
Solutions to the Multi-Component 1/R Hubbard Model
In this work we introduce one dimensional multi-component Hubbard model of
1/r hopping and U on-site energy. The wavefunctions, the spectrum and the
thermodynamics are studied for this model in the strong interaction limit
. In this limit, the system is a special example of Luttinger
liquids, exhibiting spin-charge separation in the full Hilbert space.
Speculations on the physical properties of the model at finite on-site energy
are also discussed.Comment: 9 pages, revtex, Princeton-May1
Surface code quantum computing by lattice surgery
In recent years, surface codes have become a leading method for quantum error
correction in theoretical large scale computational and communications
architecture designs. Their comparatively high fault-tolerant thresholds and
their natural 2-dimensional nearest neighbour (2DNN) structure make them an
obvious choice for large scale designs in experimentally realistic systems.
While fundamentally based on the toric code of Kitaev, there are many variants,
two of which are the planar- and defect- based codes. Planar codes require
fewer qubits to implement (for the same strength of error correction), but are
restricted to encoding a single qubit of information. Interactions between
encoded qubits are achieved via transversal operations, thus destroying the
inherent 2DNN nature of the code. In this paper we introduce a new technique
enabling the coupling of two planar codes without transversal operations,
maintaining the 2DNN of the encoded computer. Our lattice surgery technique
comprises splitting and merging planar code surfaces, and enables us to perform
universal quantum computation (including magic state injection) while removing
the need for braided logic in a strictly 2DNN design, and hence reduces the
overall qubit resources for logic operations. Those resources are further
reduced by the use of a rotated lattice for the planar encoding. We show how
lattice surgery allows us to distribute encoded GHZ states in a more direct
(and overhead friendly) manner, and how a demonstration of an encoded CNOT
between two distance 3 logical states is possible with 53 physical qubits, half
of that required in any other known construction in 2D.Comment: Published version. 29 pages, 18 figure
Evaluation of two lyophilized molecular assays to rapidly detect foot-and-mouth disease virus directly from clinical samples in field settings
Accurate, timely diagnosis is essential for the control, monitoring and eradication of footâandâmouth disease (FMD). Clinical samples from suspect cases are normally tested at reference laboratories. However, transport of samples to these centralized facilities can be a lengthy process that can impose delays on critical decision making. These concerns have motivated work to evaluate simpleâtoâuse technologies, including molecularâbased diagnostic platforms, that can be deployed closer to suspect cases of FMD. In this context, FMD virus (FMDV)âspecific reverse transcription loopâmediated isothermal amplification (RTâLAMP) and realâtime RTâPCR (rRTâPCR) assays, compatible with simple sample preparation methods and in situ visualization, have been developed which share equivalent analytical sensitivity with laboratoryâbased rRTâPCR. However, the lack of robust âreadyâtoâuse kitsâ that utilize stabilized reagents limits the deployment of these tests into field settings. To address this gap, this study describes the performance of lyophilized rRTâPCR and RTâLAMP assays to detect FMDV. Both of these assays are compatible with the use of fluorescence to monitor amplification in realâtime, and for the RTâLAMP assays end point detection could also be achieved using molecular lateral flow devices. Lyophilization of reagents did not adversely affect the performance of the assays. Importantly, when these assays were deployed into challenging laboratory and field settings within East Africa they proved to be reliable in their ability to detect FMDV in a range of clinical samples from acutely infected as well as convalescent cattle. These data support the use of highly sensitive molecular assays into field settings for simple and rapid detection of FMDV
UV continuum emission and diagnostics of hydrogen-containing non-equilibrium plasmas
For the first time the emission of the radiative dissociation continuum of
the hydrogen molecule ( electronic
transition) is proposed to be used as a source of information for the
spectroscopic diagnostics of non-equilibrium plasmas. The detailed analysis of
excitation-deactivation kinetics, rate constants of various collisional and
radiative transitions and fitting procedures made it possible to develop two
new methods of diagnostics of: (1) the ground state
vibrational temperature from the relative intensity
distribution, and (2) the rate of electron impact dissociation
(d[\mbox{H_{2}}]/dt)_{\text{diss}} from the absolute intensity of the
continuum. A known method of determination of from relative
intensities of Fulcher- bands was seriously corrected and simplified
due to the revision of transition probabilities and cross sections of
electron impact excitation. General considerations are illustrated
with examples of experiments in pure hydrogen capillary-arc and H+Ar
microwave discharges.Comment: REVTeX, 25 pages + 12 figures + 9 tables. Phys. Rev. E, eprint
replaced because of resubmission to journal after referee's 2nd repor
Theory of Spontaneous Polarization of Endohedral Fullerenes
A pseudo-Jahn-Teller model describing central atom distortions is proposed
for endohedral fullerenes of the form A@C where A is either a rare gas
or a metal atom. A critical (dimensionless) coupling is found, below
which the symmetric configuration is stable and above which inversion symmetry
is broken. Vibronic parameters are given for selected endohedral fullerenes.Comment: 4 pages, REVTEX, 1 Postscript figure. [Phys. Rev. Lett. (in press)
Examination of the astrophysical S-factors of the radiative proton capture on 2H, 6Li, 7Li, 12C and 13C
Astrophysical S-factors of radiative capture reactions on light nuclei have
been calculated in a two-cluster potential model, taking into account the
separation of orbital states by the use of Young schemes. The local two-body
potentials describing the interaction of the clusters were determined by
fitting scattering data and properties of bound states. The many-body character
of the problem is approximatively accounted for by Pauli forbidden states. An
important feature of the approach is the consideration of the dependence of the
interaction potential between the clusters on the orbital Young schemes, which
determine the permutation symmetry of the nucleon system. Proton capture on 2H,
6Li, 7Li, 12C, and 13C was analyzed in this approach. Experimental data at low
energies were described reasonably well when the phase shifts for
cluster-cluster scattering, extracted from precise data, were used. This shows
that decreasing the experimental error on differential elastic scattering cross
sections of light nuclei at astrophysical energies is very important also to
allow a more accurate phase shift analysis. A future increase in precision will
allow more definite conclusions regarding the reaction mechanisms and
astrophysical conditions of thermonuclear reactions.Comment: 40p., 9 fig., 83 ref. arXiv admin note: substantial text overlap with
arXiv:1005.1794, arXiv:1112.1760, arXiv:1005.198
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