Legacy and shockwaves: A spatial analysis of strengthening resilience of the power grid in Connecticut

Grid resilience and reliability are pivotal in the transition to low and zero carbon energy systems. Tree-trimming operations (TTOs) have become a pivotal tool for increasing the resilience power grids, especially in highly forested regions. Building on recent literature, we aim at assessing the temporal and spatial extents of the benefits that TTOs produce on the grid from three perspectives: the frequency, extent, and duration of outages. We use a unique dataset provided by Eversource Energy, New England's largest utility company, with outage events from 2009 to 2015. We employ spatial econometrics to investigate both the legacy and spatial extent of TTOs. Our results show TTOs benefits occur for all three metrics for at least 4 years, and benefits spillover to up to 2 km throughout the treated areas, with significant spatial spillovers across the state greater than direct effects. Implications lead to supporting TTOs as part of the hardening policies for utility companies, especially as home-based activities increase in importance in a post-COVID19 world

Let us buy sustainable! The impact of cash mobs on sustainable consumption: Experimental results

Cash mob is a practice where groups of people gather at local shops to buy a given product (usually with a strong sustainable feature) and make their decisions visible to the general public. With our paper we aim to assess the effectiveness of the cash mob as a behavioural tool and provide a better understanding of the behavioural triggers of consumers’ decision making process. We run a laboratory experiment where we mimic sustainable consumption and the cash mob treatment is embedded in a sequential game structure with/without an environmental frame. We find that the cash mob treatment has a positive gross effect, that is, the share of sustainable consumers is significantly higher in treated sessions. We also document a significant effect of expectations about the number of those eliciting a sustainable behaviour depending on participants’ previous choices. Our results suggest that cash mob-like mechanisms can help to solve social dilemmas like sustainable consumption with entirely private solutions (not based on punishment like taxes but on positive action), and with no costs for government budgets

Tissue Mimicking Materials for Multi-Modality Breast Phantoms

The paper proposes two different Tissue Mimicking Material (TMM) techniques for the development of breast phantoms which are suitable for multi-modality imaging. In particular, the focus is on the behavior of dielectric and acoustic properties when fat, sodium chloride and sugar are added to the mixtures

Kidney transplantation and withdrawal rates among wait-listed first-generation immigrants in Italy

Background: Multiple barriers diminish access to kidney transplantation (KT) in immigrant compared to non-immigrant populations. It is unknown whether immigration status reduces the likelihood of KT after wait-listing despite universal healthcare coverage with uniform access to transplantation. Methods: We retrospectively collected data of all adult waiting list (WL) registrants in Italy (2010-20) followed for 5 years until death, KT in a foreign center, deceased-donor kidney transplant (DDKT), living-donor kidney transplant (LDKT) or permanent withdrawal from the WL. We calculated adjusted relative probability of DDKT, LDKT and permanent WL withdrawal in different immigrant categories using competing-risks multiple regression models. Results: Patients were European Union (EU)-born (n = 21 624), Eastern European-born (n = 606) and non-European-born (n = 1944). After controlling for age, sex, blood type, dialysis vintage, case-mix and sensitization status, non-European-born patients had lower LDKT rates compared to other immigrant categories: LDKT adjusted relative probability of non-European-born vs. Eastern European-born 0.51 (95% CI: 0.33-0.79; P = 0.002); of non-European-born vs. EU-Born: 0.65 (95% CI: 0.47-0.82; P = 0.001). Immigration status did not affect the rate of DDKT or permanent WL withdrawal. Conclusions: Among EU WL registrants, non-European immigration background is associated with reduced likelihood of LDKT but similar likelihood of DDKT and permanent WL withdrawal. Wherever not available, new national policies should enable coverage of travel and medical fees for living-donor surgery and follow-up for non-resident donors to improve uptake of LDKT in immigrant patients, and provide KT education that is culturally competent, individually tailored and easily understandable for patients and their potential living donors

Static and dynamic evaluation of pelvic floor disorders with an open low-field tilting magnet.

AIM: To assess the feasibility of magnetic resonance defaecography (MRD) in pelvic floor disorders using an open tilting magnet with a 0.25 T static field and to compare the results obtained from the same patient both in supine and orthostatic positions. MATERIALS AND METHODS: From May 2010 to November 2011, 49 symptomatic female subjects (mean age 43.5 years) were enrolled. All the patients underwent MRD in the supine and orthostatic positions using three-dimensional (3D) hybrid contrast-enhanced (HYCE) sequences and dynamic gradient echo (GE) T1-weighted sequences. All the patients underwent conventional defaecography (CD) to correlate both results. Two radiologists evaluated the examinations; inter and intra-observer concordance was measured. The results obtained in the two positions were compared between them and with CD. RESULTS: The comparison between CD and MRD found statistically significant differences in the evaluation of anterior and posterior rectocoele during defaecation in both positions and of rectal prolapse under the pubo-coccygeal line (PCL) during evacuation, only in the supine position (versus MRD orthostatic: rectal prolapse p < 0.0001; anterior rectocoele p < 0.001; posterior rectocoele p = 0.008; versus CD: rectal prolapse p < 0.0001; anterior rectocoele p < 0.001; posterior rectocoele p = 0.01). The value of intra-observer intra-class correlation coefficient (ICC) ranged from good to excellent; the interobserver ICC from moderate to excellent. CONCLUSION: MRD is feasible with an open low-field tilting magnet, and it is more accurate in the orthostatic position than in the supine position to evaluate pelvic floor disorders

The quassinoid derivative NBT-272 targets both the AKT and ERK signaling pathways in embryonal tumors

The quassinoid analogue NBT-272 has been reported to inhibit MYC, thus warranting a further effort to better understand its preclinical properties in models of embryonal tumors (ET), a family of childhood malignancies sharing relevant biological and genetic features such as deregulated expression of MYC oncogenes. In our study, NBT-272 displayed a strong anti-proliferative activity in vitro that resulted from the combination of diverse biological effects, ranging from G1/S arrest of the cell cycle to apoptosis and autophagy. The compound prevented the full activation of both the eukaryotic initiation factor 4E (eIF4E) and its binding protein 4EBP-1, regulating cap-dependent protein translation. Interestingly, all responses induced by NBT-272 in ET could be attributed to interference with two main pro-proliferative signaling pathways, i.e. the AKT and the MEK/extracellular signal-regulated kinase (ERK) pathways. These findings also suggested that the depleting effect of NBT-272 on MYC protein expression occurred via indirect mechanisms, rather than selective inhibition. Finally, the ability of NBT-272 to arrest tumor growth in a xenograft model of neuroblastoma plays a role in the strong anti-tumor activity of this compound, both in vitro and in vivo, with its potential to target cell-survival pathways that are relevant for the development and progression of ET

Let us buy sustainable! The impact of cash mobs on sustainable consumption: Experimental results

Cash mob is a practice where groups of people gather at local shops to buy a given product (usually with a strong sustainable feature) and make their decisions visible to the general public. With our paper we aim to assess the effectiveness of the cash mob as a behavioural tool and provide a better understanding of the behavioural triggers of consumers’ decision making process. We run a laboratory experiment where we mimic sustainable consumption and the cash mob treatment is embedded in a sequential game structure with/without an environmental frame. We find that the cash mob treatment has a positive gross effect, that is, the share of sustainable consumers is significantly higher in treated sessions. We also document a significant effect of expectations about the number of those eliciting a sustainable behaviour depending on participants’ previous choices. Our results suggest that cash mob-like mechanisms can help to solve social dilemmas like sustainable consumption with entirely private solutions (not based on punishment like taxes but on positive action), and with no costs for government budgets