Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane

p53 is a transcription factor that induces growth arrest or apoptosis in response to cellular stress. To identify new p53-inducible proapoptotic genes, we compared, by differential display, the expression of genes in spleen or thymus of normal and p53 nullizygote mice after γ-irradiation of whole animals. We report the identification and characterization of human and mouse Scotin homologues, a novel gene directly transactivated by p53. The Scotin protein is localized to the ER and the nuclear membrane. Scotin can induce apoptosis in a caspase-dependent manner. Inhibition of endogenous Scotin expression increases resistance to p53-dependent apoptosis induced by DNA damage, suggesting that Scotin plays a role in p53-dependent apoptosis. The discovery of Scotin brings to light a role of the ER in p53-dependent apoptosis

Bi-Lipschitz geometry of weighted homogeneous surface singularities

We show that a weighted homogeneous complex surface singularity is metrically conical (i.e., bi-Lipschitz equivalent to a metric cone) only if its two lowest weights are equal. We also give an example of a pair of weighted homogeneous complex surface singularities that are topologically equivalent but not bi-Lipschitz equivalent.Comment: 5 pages. Added result that nonhomogeneous cyclic quotients are not conica

Infrared scintillation yield in gaseous and liquid argon

The study of primary and secondary scintillations in noble gases and liquids is of paramount importance to rare-event experiments using noble gas media. In the present work, the scintillation yield in gaseous and liquid Ar has for the first time been measured in the near infrared (NIR) and visible region, both for primary and secondary (proportional) scintillations, using Geiger-mode avalanche photodiodes (G-APDs) and pulsed X-ray irradiation. The primary scintillation yield of the fast component was measured to be 17000 photon/MeV in gaseous Ar in the NIR, in the range of 690-1000 nm, and 510 photon/MeV in liquid Ar, in the range of 400-1000 nm. Proportional NIR scintillations (electroluminescence) in gaseous Ar have been also observed; their amplification parameter at 163 K was measured to be 13 photons per drifting electron per kV. Possible applications of NIR scintillations in high energy physics experiments are discussed.Comment: 6 pages, 5 figures. Submitted to Europhysics Letter. Revised Figs. 3 and

Competing magnetic orders in the superconducting state of Nd-doped CeRhIn5_{5} under pressure

Applied pressure drives the heavy-fermion antiferromagnet CeRhIn$_{5}$ towards a quantum critical point that becomes hidden by a dome of unconventional superconductivity. Magnetic fields suppress this superconducting dome, unveiling the quantum phase transition of local character. Here, we show that $5\%$ magnetic substitution at the Ce site in CeRhIn$_{5}$, either by Nd or Gd, induces a zero-field magnetic instability inside the superconducting state. This magnetic state not only should have a different ordering vector than the high-field local-moment magnetic state, but it also competes with the latter, suggesting that a spin-density-wave phase is stabilized in zero field by Nd and Gd impurities - similarly to the case of Ce$_{0.95}$Nd$_{0.05}$CoIn$_{5}$. Supported by model calculations, we attribute this spin-density wave instability to a magnetic-impurity driven condensation of the spin excitons that form inside the unconventional superconducting state

Optical-force laws for guided light in linear media

CNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOFAPEMIG - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE MINAS GERAISCAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL E NÍVEL SUPERIORThe mechanical response of transparent materials to optical forces is a topic that concerns a wide range of fields, from the manipulation of biological material by optical tweezers to the design of nano-optomechanical systems. However, the fundamental aspects of such forces have always been surrounded by controversies, and several different formulations have been proposed. In this paper, we propose a general stress tensor formalism to put all optical forces in a consistent presentation that allows us to study how different predictions emerge, and use the specific case of light propagating as a superposition of guided modes in lossless dielectric waveguides as a physical example. We use this formalism to calculate optical forces for straight and curved waveguide sections and all possible excitation configurations for a given set of coupled eigenmodes, and then compare the results for each of the known proposed optical-force laws in a framework that permits distinguishing where there will be differences between the force laws proposed. The general formalism also allows us to show that proper use of the divergence theorem is crucial to account for all force terms, many of which vanish if the procedure most commonly used is applied for situations other than eigenmodes in straight waveguides in vacuum. Finally, it is known that discrepancies in the predicted forces arise from the incompleteness of each stress tensor with respect to the total-energy-momentum tensor of the system. A better understanding of how different stress tensors predict very different forces for certain waveguide geometries should open a pathway to identifying how to properly assemble the full tensor, as well as for experimental tests to confirm the predictions.100117CNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOFAPEMIG - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE MINAS GERAISCAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL E NÍVEL SUPERIORCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOFAPEMIG - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE MINAS GERAISCAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL E NÍVEL SUPERIORSem informaçãoSem informaçãoSem informaçã

Persistence in the zero-temperature dynamics of the QQ-states Potts model on undirected-directed Barab\'asi-Albert networks and Erd\"os-R\'enyi random graphs

The zero-temperature Glauber dynamics is used to investigate the persistence probability $P(t)$ in the Potts model with $Q=3,4,5,7,9,12,24,64, 128$, $256, 512, 1024,4096,16384$,..., $2^{30}$ states on {\it directed} and {\it undirected} Barab\'asi-Albert networks and Erd\"os-R\'enyi random graphs. In this model it is found that $P(t)$ decays exponentially to zero in short times for {\it directed} and {\it undirected} Erd\"os-R\'enyi random graphs. For {\it directed} and {\it undirected} Barab\'asi-Albert networks, in contrast it decays exponentially to a constant value for long times, i.e, $P(\infty)$ is different from zero for all $Q$ values (here studied) from $Q=3,4,5,..., 2^{30}$; this shows "blocking" for all these $Q$ values. Except that for $Q=2^{30}$ in the {\it undirected} case $P(t)$ tends exponentially to zero; this could be just a finite-size effect since in the other "blocking" cases you may have only a few unchanged spins.Comment: 14 pages, 8 figures for IJM

Modelagem de crescimento e produção usando o modelo Simflora.

Importância da modelagem de dinâmica florestal na Amazônia Brasileira; Modelagem de crescimento e produção usando o Simflora; Outros documentos disponíveis; Instalação; Simulações únicas; Dados; Começando; Janelas de exibição; Rodando o modelo; Resultados; Simulando silvicultura; A escolha de módulos e valores dos parâmetros; Exemplo; Simulações múltiplas; Começando uma simulação múltipla; Criando um arquivo de dados de saída; Rodando simulações múltiplas; Examinando e analisando os resultados; Experiências de uso do Simflora e suas implicações para políticas públicas; Indonésia; Guiana Inglesa; Brasil; Padrões observados em relação à exploração madeireira e às lacunas de conhecimento de dinâmica florestal de diferentes países tropicais

Monte Carlo simulations of 2d hard core lattice gases

Monte Carlo simulations are used to study lattice gases of particles with extended hard cores on a two dimensional square lattice. Exclusions of one and up to five nearest neighbors (NN) are considered. These can be mapped onto hard squares of varying side length, $\lambda$ (in lattice units), tilted by some angle with respect to the original lattice. In agreement with earlier studies, the 1NN exclusion undergoes a continuous order-disorder transition in the Ising universality class. Surprisingly, we find that the lattice gas with exclusions of up to second nearest neighbors (2NN) also undergoes a continuous phase transition in the Ising universality class, while the Landau-Lifshitz theory predicts that this transition should be in the universality class of the XY model with cubic anisotropy. The lattice gas of 3NN exclusions is found to undergo a discontinuous order-disorder transition, in agreement with the earlier transfer matrix calculations and the Landau-Lifshitz theory. On the other hand, the gas of 4NN exclusions once again exhibits a continuous phase transition in the Ising universality class -- contradicting the predictions of the Landau-Lifshitz theory. Finally, the lattice gas of 5NN exclusions is found to undergo a discontinuous phase transition.Comment: 13 pages, lots of figure