17,820 research outputs found
Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane
p53 is a transcription factor that induces growth arrest or apoptosis in response to cellular stress. To identify new p53-inducible proapoptotic genes, we compared, by differential display, the expression of genes in spleen or thymus of normal and p53 nullizygote mice after γ-irradiation of whole animals. We report the identification and characterization of human and mouse Scotin homologues, a novel gene directly transactivated by p53. The Scotin protein is localized to the ER and the nuclear membrane. Scotin can induce apoptosis in a caspase-dependent manner. Inhibition of endogenous Scotin expression increases resistance to p53-dependent apoptosis induced by DNA damage, suggesting that Scotin plays a role in p53-dependent apoptosis. The discovery of Scotin brings to light a role of the ER in p53-dependent apoptosis
FM 047-02: a collisional pair of galaxies with a ring
Aims. We investigate the nature of the galaxy pair FM 047-02, which has been
proposed as an archetype of the Solitaire types of peculiar (collisional) ring
galaxies. Methods. The study is based on long-slit spectrophotometric data in
the range of 3500-9500 angstrons obtained with the Gemini Multi-ObjectComment: 07 pages, 06 figures, 02 tables. arXiv admin note: text overlap with
arXiv:1206.071
Análise comparativa da quantificação da acção da neve de acordo com o RSA, a norma espanhola NBE e o EC1
A quantificação da acção da neve de acordo com a regulamentação em vigor em
Portugal, Espanha e com o estabelecido no Eurocódigo 1 fornece resultados muito distintos.
Neste trabalho é realizada uma análise comparativa entre o método de cálculo indicado pelo
Regulamento de Segurança e Acções para Estruturas de EdifÃcios e Pontes, a norma espanhola
NBE e o Eurocódigo 1. Foram analisados e comparados os vários parâmetros intervenientes
na quantificação da acção da neve
Tailored graph ensembles as proxies or null models for real networks I: tools for quantifying structure
We study the tailoring of structured random graph ensembles to real networks,
with the objective of generating precise and practical mathematical tools for
quantifying and comparing network topologies macroscopically, beyond the level
of degree statistics. Our family of ensembles can produce graphs with any
prescribed degree distribution and any degree-degree correlation function, its
control parameters can be calculated fully analytically, and as a result we can
calculate (asymptotically) formulae for entropies and complexities, and for
information-theoretic distances between networks, expressed directly and
explicitly in terms of their measured degree distribution and degree
correlations.Comment: 25 pages, 3 figure
Optical and Near Infrared Study of the Cepheus E outflow, a very low excitation object
We present images and spectra of the Cepheus E (Cep E) region at both optical
and infrared wavelengths. Only the brightest region of the southern lobe of the
Cep E outflow reveals optical emission, suggesting that the extinction close to
the outflow source plays an important r\^ole in the observed difference between
the optical and IR morphologies. Cep E is a unique object since it provides a
link between the spectroscopic properties of the optical Herbig-Haro (HH)
objects and those of deeply embedded outflows.Comment: Accepted Astron. J., 8 files: paper, tables plus 6 figure
Interplay between superconductivity and itinerant magnetism in underdoped BaKFeAs ( 0.2) probed by the response to controlled point-like disorder
The response of superconductors to controlled introduction of point-like
disorder is an important tool to probe their microscopic electronic collective
behavior. In the case of iron-based superconductors (IBS), magnetic
fluctuations presumably play an important role in inducing high temperature
superconductivity. In some cases, these two seemingly incompatible orders
coexist microscopically. Therefore, understanding how this unique coexistence
state is affected by disorder can provide important information about the
microscopic mechanisms involved. In one of the most studied pnictide family,
hole-doped BaKFeAs (BaK122), this coexistence occurs over a
wide range of doping levels, 0.16~~0.25. We used
relativistic 2.5 MeV electrons to induce vacancy-interstitial (Frenkel) pairs
that act as efficient point-like scattering centers. Upon increasing dose of
irradiation, the superconducting transition temperature decreases
dramatically. In the absence of nodes in the order parameter this provides a
strong support for a sign-changing pairing. Simultaneously, in the
normal state, there is a strong violation of the Matthiessen's rule and a
decrease (surprisingly, at the same rate as ) of the magnetic transition
temperature , which indicates the itinerant nature of the long-range
magnetic order. Comparison of the hole-doped BaK122 with electron-doped
Ba(FeCo)As (FeCo122) with similar 110~K,
0.02, reveals significant differences in the normal states, with no
apparent Matthiessen's rule violation above on the electron-doped
side. We interpret these results in terms of the distinct impact of impurity
scattering on the competing itinerant antiferromagnetic and
superconducting orders
Modelagem de crescimento e produção usando o modelo Simflora.
Importância da modelagem de dinâmica florestal na Amazônia Brasileira; Modelagem de crescimento e produção usando o Simflora; Outros documentos disponÃveis; Instalação; Simulações únicas; Dados; Começando; Janelas de exibição; Rodando o modelo; Resultados; Simulando silvicultura; A escolha de módulos e valores dos parâmetros; Exemplo; Simulações múltiplas; Começando uma simulação múltipla; Criando um arquivo de dados de saÃda; Rodando simulações múltiplas; Examinando e analisando os resultados; Experiências de uso do Simflora e suas implicações para polÃticas públicas; Indonésia; Guiana Inglesa; Brasil; Padrões observados em relação à exploração madeireira e à s lacunas de conhecimento de dinâmica florestal de diferentes paÃses tropicais
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