Dielectric mismatch and shallow donor impurities in GaN/HfO2 quantum wells

In this work we investigate electron-impurity binding energy in GaN/HfO$_2$ quantum wells. The calculation considers simultaneously all energy contributions caused by the dielectric mismatch: (i) image self-energy (i.e., interaction between electron and its image charge), (ii) the direct Coulomb interaction between the electron-impurity and (iii) the interactions among electron and impurity image charges. The theoretical model account for the solution of the time-dependent Schr\"odinger equation and the results shows how the magnitude of the electron-impurity binding energy depends on the position of impurity in the well-barrier system. The role of the large dielectric constant in the barrier region is exposed with the comparison of the results for GaN/HfO$_2$ with those of a more typical GaN/AlN system, for two different confinement regimes: narrow and wide quantum wells.Comment: 6 Pages, 7 figure

Desenvolvimento de tecnologias para a melhoria do sistema de criação em cativeiro do pirarucu, Arapaima gigas.

bitstream/item/86403/1/Digitalizar0144.pd

Paraoxonase 2 overexpression inhibits tumor development in a mouse model of ovarian cancer.

Ovarian cancer (OC) is most lethal malignancy among all gynecological cancer. Large bodies of evidences suggest that mitochondrial-derived ROS play a critical role in the development and progression of OC. Paraoxonase 2 (PON2) is a membrane-associated lactonase with anti-oxidant properties. PON2 deficiency aggravates mitochondrial ROS formation, systemic inflammation, and atherosclerosis. The role of PON2 in cancer development remains unknown. In this report, in human, we identified that PON2 expression is higher in early stages (but not in late stages) of OC when compared to normal tissue. Using a mouse xenograft model of OC, we demonstrate that overexpression of PON2 prevents tumor formation. Mechanistically, PON2 decreases OC cell proliferation by inhibiting insulin like growth factor-1 (IGF-1) expression and signaling. Intriguingly, PON2 reduces c-Jun-mediated transcriptional activation of IGF-1 gene by decreasing mitochondrial superoxide generation. In addition, PON2 impairs insulin like growth factor-1 receptor (IGF-1R) signaling in OC cells by altering cholesterol homeostasis, which resulted in reduced caveolin-1/IGF-1R interaction and IGF-1R phosphorylation. Taken together, we report for the first time that PON2 acts as a tumor suppressor in the early stage of OC by reducing IGF-1 production and its signaling, indicating PON2 activation might be a fruitful strategy to inhibit early stage ovarian tumor

Optimization of the transmission of observable expectation values and observable statistics in Continuous Variable Teleportation

We analyze the statistics of observables in continuous variable quantum teleportation in the formalism of the characteristic function. We derive expressions for average values of output state observables in particular cumulants which are additive in terms of the input state and the resource of teleportation. Working with Squeezed Bell-like states, which may be optimized in a free parameter for better teleportation performance we discuss the relation between resources optimal for fidelity and for different observable averages. We obtain the values of the free parameter which optimize the central momenta and cumulants up to fourth order. For the cumulants the distortion between in and out states due to teleportation depends only on the resource. We obtain optimal parameters for the second and fourth order cumulants which do not depend on the squeezing of the resource. The second order central momenta which is equal to the second order cumulants and the photon number average are optimized by the same resource. We show that the optimal fidelity resource, found in reference (Phys. Rev. A {\bf 76}, 022301 (2007)) to depend also on the characteristics of input, tends for high squeezing to the resource which optimizes the second order momenta. A similar behavior is obtained for the resource which optimizes the photon statistics which is treated here using the sum of the squared differences in photon probabilities of input and output states as the distortion measure. This is interpreted to mean that the distortions associated to second order momenta dominates the behavior of the output state for large squeezing of the resource. Optimal fidelity and optimal photon statistics resources are compared and is shown that for mixtures of Fock states they are equivalent.Comment: 25 pages, 11 figure

A consistent scalar-tensor cosmology for inflation, dark energy and the Hubble parameter

The authors are grateful for financial support to the Cruickshank Trust (CW), EPSRC/GG-Top (CW, JR), Omani Government (MA), Science Without Borders programme, CNPq, Brazil (DR), and STFC/CfFP (CW, AM, RB, JM). CW and AM acknowledge the hospitality of CERN, where this work was started. The University of Aberdeen and University of Edinburgh are charitable bodies registered in Scotland, with respective registration numbers SC013683 and SC005336.Peer reviewedPostprin