Recurrent Non-Hodgkin’s lymphoma in the uterine cervix: a case report and a review of the literature

Background. Lymphomas are a heterogeneous group of malignant lymphoproliferative diseases. As primary localization, the most common histological subtype of female genital lymphomas is a Non-Hodgkin Lymphoma (NHL), the diffuse large B-cell type. However cervical relapse of NHL is a very rare condition (0.3%). Case presentation. A 42-year-old Peruvian woman experienced relapse of NHL with uterine localization. She complained at first of abnormal vaginal bleeding and stranguria. The cervical biopsy performed showed a diffuse large B-cell lymphoma in the uterine cervix. The lack of clinical studies on this topic and its rarity make this type of recurrence very difficult to treat. Conclusions. In case of a woman with vaginal bleeding and history of NHL, a disease relapse should always be considered, and a biopsy should be performed to confirm the diagnosis. © 2023, EDRA S.p.A. All rights reserved

Superscaling and Neutral Current Quasielastic Neutrino-Nucleus Scattering beyond the Relativistic Fermi Gas Model

The superscaling analysis is extended to include quasielastic (QE) scattering via the weak neutral current of neutrinos and antineutrinos from nuclei. The scaling function obtained within the coherent density fluctuation model (used previously in calculations of QE inclusive electron and charge-changing (CC) neutrino scattering) is applied to neutral current neutrino and antineutrino scattering with energies of 1 GeV from $^{12}$C with a proton and neutron knockout (u-channel inclusive processes). The results are compared with those obtained using the scaling function from the relativistic Fermi gas model and the scaling function as determined from the superscaling analysis (SuSA) of QE electron scattering.Comment: 10 pages, 6 figures, published in Phys. Rev.

Superscaling in dilute Fermi gas and its relation to general properties of the nucleon momentum distribution in nuclei

The superscaling observed in inclusive electron scattering is described within the dilute Fermi gas model with interaction between the particles. The comparison with the relativistic Fermi gas (RFG) model without interaction shows an improvement in the explanation of the scaling function $f(\psi ')$ in the region $\psi ' < -1$, where the RFG result is $f(\psi ') = 0$. It is found that the behavior of $f(\psi ')$ for $\psi ' < -1$ depends on the particular form of the general power-law asymptotics of the momentum distribution $n(k)\sim 1/ k^{4+m}$ at large $k$. The best agreement with the empirical scaling function is found for $m\simeq 4.5$ in agreement with the asymptotics of $n(k)$ in the coherent density fluctuation model where $m = 4$. Thus, superscaling gives information about the asymptotics of $n(k)$ and the NN forces.Comment: 6 pages, 5 figures, accepted for publication in Physical Review

Superscaling and Charge-Changing Neutrino Scattering from Nuclei in the Δ\boldsymbol \Delta-Region beyond the Relativistic Fermi Gas Model

The superscaling analysis using the scaling function obtained within the coherent density fluctuation model is extended to calculate charge-changing neutrino and antineutrino scattering on $^{12}$C at energies from 1 to 2 GeV not only in the quasielastic but also in the delta excitation region. The results are compared with those obtained using the scaling functions from the relativistic Fermi gas model and from the superscaling analysis of inclusive scattering of electrons from nuclei.Comment: 9 pages, 8 figures, accepted for publication in Physical Review

Cation binding to 15-TBA quadruplex DNA is a multiple-pathway cation-dependent process

A combination of explicit solvent molecular dynamics simulation (30 simulations reaching 4 µs in total), hybrid quantum mechanics/molecular mechanics approach and isothermal titration calorimetry was used to investigate the atomistic picture of ion binding to 15-mer thrombin-binding quadruplex DNA (G-DNA) aptamer. Binding of ions to G-DNA is complex multiple pathway process, which is strongly affected by the type of the cation. The individual ion-binding events are substantially modulated by the connecting loops of the aptamer, which play several roles. They stabilize the molecule during time periods when the bound ions are not present, they modulate the route of the ion into the stem and they also stabilize the internal ions by closing the gates through which the ions enter the quadruplex. Using our extensive simulations, we for the first time observed full spontaneous exchange of internal cation between quadruplex molecule and bulk solvent at atomistic resolution. The simulation suggests that expulsion of the internally bound ion is correlated with initial binding of the incoming ion. The incoming ion then readily replaces the bound ion while minimizing any destabilization of the solute molecule during the exchange

Consensus recommendation for mouse models of ocular hypertension to study aqueous humor outflow and its mechanisms

Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings