112 research outputs found
The Majorana neutrino masses, neutrinoless double beta decay and nuclear matrix elements
The effective Majorana neutrino mass is evaluated by using the latest results
of neutrino oscillation experiments. The problems of the neutrino mass
spectrum,absolute mass scale of neutrinos and the effect of CP phases are
addressed. A connection to the next generation of the neutrinoless double beta
decay (0nbb-decay) experiments is discussed. The calculations are performed for
76Ge, 100Mo, 136Xe and 130Te by using the advantage of recently evaluated
nuclear matrix elements with significantly reduced theoretical uncertainty. An
importance of observation of the 0nbb-decay of several nuclei is stressed.Comment: 29 pages, 5 figures, EXO (10 t) experiment considere
Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline (vol 9, 101, 2017)
Pathophysiology, epidemiology and therapy of agein
Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations
Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations. Towards addressing this deficiency, we expand PRS development for CRC by incorporating Asian ancestry data (21,731 cases; 47,444 controls) into European ancestry training datasets (78,473 cases; 107,143 controls). The AUC estimates (95% CI) of PRS are 0.63(0.62-0.64), 0.59(0.57-0.61), 0.62(0.60-0.63), and 0.65(0.63-0.66) in independent datasets including 1681-3651 cases and 8696-115,105 controls of Asian, Black/African American, Latinx/Hispanic, and non-Hispanic White, respectively. They are significantly better than the European-centric PRS in all four major US racial and ethnic groups (p-values < 0.05). Further inclusion of non-European ancestry populations, especially Black/African American and Latinx/Hispanic, is needed to improve the risk prediction and enhance equity in applying PRS in clinical practice
- …