271 research outputs found
Role of hexagonal boron nitride in protecting ferromagnetic nanostructures from oxidation
Ferromagnetic contacts are widely used to inject spin polarized currents into
non-magnetic materials such as semiconductors or 2-dimensional materials like
graphene. In these systems, oxidation of the ferromagnetic materials poses an
intrinsic limitation on device performance. Here we investigate the role of
ex-situ transferred chemical vapour deposited hexagonal boron nitride (hBN) as
an oxidation barrier for nanostructured cobalt and permalloy electrodes. The
chemical state of the ferromagnets was investigated using X-ray photoemission
electron microscopy owing to its high sensitivity and lateral resolution. We
have compared the oxide thickness formed on ferromagnetic nanostructures
covered by hBN to uncovered reference structures. Our results show that hBN
reduces the oxidation rate of ferromagnetic nanostructures suggesting that it
could be used as an ultra-thin protection layer in future spintronic devices.Comment: 7 pages, 6 figure
Longitudinal increase in the detection rate of Mycobacterium chimaera in heater-cooler device-derived water samples
Colonization with Mycobacterium chimaera and other nontuberculous mycobacteria (NTM) has been reported for heater-cooler devices (HCD) produced by several manufacturers. Up to now, exclusively LivaNova (London, UK) HCDs have been associated with M. chimaera infections after cardiac surgery. The vast majority of studies on HCD colonization were cross-sectional. We were interested in longitudinal dynamics of mycobacterial growth in HCD water samples and analyzed data of a prospective mycobacterial surveillance of five LivaNova 3T HCDs. Nontuberculous mycobacteria were isolated in 319 (48.0%, 21 water samples grew more than one mycobacterial species) of a total of 665 water samples. The most frequently detected species were M. chimaera (N= 247/319, 77.4%), Mycobacterium gordonae (46/319, 14.4%) and Mycobacterium paragordonae (34/319, 10.7%). Detection rates increased longitudinally for any NTM (odds ratio (OR) per year in use: 1.60, 95% CI 1.17-2.24, P<0.001) and for M. chimaera (OR per year in use: 1.67, 95% CI 1.11-2.57, P<0.01)
Mutation of Tyr137 of the universal Escherichia coli fimbrial adhesin FimH relaxes the tyrosine gate prior to mannose binding
The most prevalent diseases manifested by Escherichia coli are acute and recurrent bladder infections and chronic inflammatory bowel diseases such as Crohn's disease. E. coli clinical isolates express the FimH adhesin, which consists of a mannose-specific lectin domain connected via a pilin domain to the tip of type 1 pili. Although the isolated FimH lectin domain has affinities in the nanomolar range for all high-mannosidic glycans, differentiation between these glycans is based on their capacity to form predominantly hydrophobic interactions within the tyrosine gate at the entrance to the binding pocket. In this study, novel crystal structures of tyrosine-gate mutants of FimH, ligand-free or in complex with heptyl α - D - O -mannopyranoside or 4-biphenyl α - D - O- mannopyranoside, are combined with quantum-mechanical calculations and molecular-dynamics simulations. In the Y48A FimH crystal structure, a large increase in the dynamics of the alkyl chain of heptyl α - D - O -mannopyranoside attempts to compensate for the absence of the aromatic ring; however, the highly energetic and stringent mannose-binding pocket of wild-type FimH is largely maintained. The Y137A mutation, on the other hand, is the most detrimental to FimH affinity and specificity: (i) in the absence of ligand the FimH C-terminal residue Thr158 intrudes into the mannose-binding pocket and (ii) ethylenediaminetetraacetic acid interacts strongly with Glu50, Thr53 and Asn136, in spite of multiple dialysis and purification steps. Upon mutation, pre-ligand-binding relaxation of the backbone dihedral angles at position 137 in the tyrosine gate and their coupling to Tyr48 via the interiorly located Ile52 form the basis of the loss of affinity of the FimH adhesin in the Y137A mutant
Correlated Strength in Nuclear Spectral Function
We have carried out an (e,e'p) experiment at high momentum transfer and in
parallel kinematics to measure the strength of the nuclear spectral function
S(k,E) at high nucleon momenta k and large removal energies E. This strength is
related to the presence of short-range and tensor correlations, and was known
hitherto only indirectly and with considerable uncertainty from the lack of
strength in the independent-particle region. This experiment confirms by direct
measurement the correlated strength predicted by theory.Comment: 4 pages, 2 figures, accepted by Phys. Rev. Let
Spectral-statistics properties of the experimental and theoretical light baryon and meson spectra
Beam Asymmetry Σ for the Photoproduction of η and ή Mesons at Eγ = 8.8GeV
We report on the measurement of the beam asymmetry Σ for the reactions →γp→pη and →γp→pη′ from the GlueX experiment using an 8.2–8.8-GeV linearly polarized tagged photon beam incident on a liquid hydrogen target in Hall D at Jefferson Laboratory. These measurements are made as a function of momentum transfer −t with significantly higher statistical precision than our earlier η measurements and are the first measurements of η′ in this energy range. We compare the results to theoretical predictions based on t-channel quasiparticle exchange. We also compare the ratio of Ση to Ση′ to these models as this ratio is predicted to be sensitive to the amount of s¯s exchange in the production. We find that photoproduction of both η and η′ is dominated by natural parity exchange with little dependence on −t
Measurement of the J/ Photoproduction Cross Section Over the Full Near-Threshold Kinematic Region
We report the total and differential cross sections for J/ψ photoproduction with the large acceptance GlueX spectrometer for photon beam energies from the threshold at 8.2 GeV up to 11.44 GeV and over the full kinematic range of momentum transfer squared, t. Such coverage facilitates the extrapolation of the differential cross sections to the forward (t=0) point beyond the physical region. The forward cross section is used by many theoretical models and plays an important role in understanding J/ψ photoproduction and its relation to the J/ψ-proton interaction. These measurements of J/ψ photoproduction near threshold are also crucial inputs to theoretical models that are used to study important aspects of the gluon structure of the proton, such as the gluon generalized parton distribution of the proton, the mass radius of the proton, and the trace anomaly contribution to the proton mass. We observe possible structures in the total cross section energy dependence and find evidence for contributions beyond gluon exchange in the differential cross section close to threshold, both of which are consistent with contributions from open-charm intermediate states
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