An information-theoretic framework for semantic-multimedia retrieval

This article is set in the context of searching text and image repositories by keyword. We develop a unified probabilistic framework for text, image, and combined text and image retrieval that is based on the detection of keywords (concepts) using automated image annotation technology. Our framework is deeply rooted in information theory and lends itself to use with other media types. We estimate a statistical model in a multimodal feature space for each possible query keyword. The key element of our framework is to identify feature space transformations that make them comparable in complexity and density. We select the optimal multimodal feature space with a minimum description length criterion from a set of candidate feature spaces that are computed with the average-mutual-information criterion for the text part and hierarchical expectation maximization for the visual part of the data. We evaluate our approach in three retrieval experiments (only text retrieval, only image retrieval, and text combined with image retrieval), verify the framework’s low computational complexity, and compare with existing state-of-the-art ad-hoc models

Prostaglandin E2 stimulates the expansion of regulatory hematopoietic stem and progenitor cells in type 1 diabetes

Hematopoietic stem and progenitor cells (HSPCs) are multipotent stem cells that have been harnessed as a curative therapy for patients with hematological malignancies. Notably, the discovery that HSPCs are endowed with immunoregulatory properties suggests that HSPC-based therapeutic approaches may be used to treat autoimmune diseases. Indeed, infusion with HSPCs has shown promising results in the treatment of type 1 diabetes (T1D) and remains the only "experimental therapy" that has achieved a satisfactory rate of remission (nearly 60%) in T1D. Patients with newly diagnosed T1D have been successfully reverted to normoglycemia by administration of autologous HSPCs in association with a non-myeloablative immunosuppressive regimen. However, this approach is hampered by a high incidence of adverse effects linked to immunosuppression. Herein, we report that while the use of autologous HSPCs is capable of improving C-peptide production in patients with T1D, ex vivo modulation of HSPCs with prostaglandins (PGs) increases their immunoregulatory properties by upregulating expression of the immune checkpoint-signaling molecule PD-L1. Surprisingly, CXCR4 was upregulated as well, which could enhance HSPC trafficking toward the inflamed pancreatic zone. When tested in murine and human in vitro autoimmune assays, PG-modulated HSPCs were shown to abrogate the autoreactive T cell response. The use of PG-modulated HSPCs may thus provide an attractive and novel treatment of autoimmune diabetes

Cross-lingual C*ST*RD: English access to Hindi information

We present C*ST*RD, a cross-language information delivery system that supports cross-language information retrieval, information space visualization and navigation, machine translation, and text summarization of single documents and clusters of documents. C*ST*RD was assembled and trained within 1 month, in the context of DARPA’s Surprise Language Exercise, that selected as source a heretofore unstudied language, Hindi. Given the brief time, we could not create deep Hindi capabilities for all the modules, but instead experimented with combining shallow Hindi capabilities, or even English-only modules, into one integrated system. Various possible configurations, with different tradeoffs in processing speed and ease of use, enable the rapid deployment of C*ST*RD to new languages under various conditions

Towards a belief-revision-based adaptive and context-sensitive information retrieval system.

In an adaptive information retrieval (IR) setting, the information seekers' beliefs about which terms are relevant, or non-relevant, will naturally fluctuate. This article investigates how the theory of belief revision can be used to model adaptive IR. More specifically, belief revision logic provides a rich representation scheme to formalize retrieval contexts so as to disambiguate vague user queries. In addition, belief revision theory underpins the development of an effective mechanism to revise user profiles in accordance with information seekers' changing information needs. It is argued that information retrieval contexts can be extracted by means of the information flow text mining method so as to realize a highly autonomous adaptive IR system. The extra bonus of a belief-based IR model is that its retrieval behavior is more predictable and explanatory. Our initial experiments show that the belief-based adaptive IR system is as effective as a classical adaptive IR system. To our best knowledge, this is the first successful implementation and evaluation of a logic-based adaptive IR model which can efficiently process large IR collections

Information retrieval and text mining technologies for chemistry

Efficient access to chemical information contained in scientific literature, patents, technical reports, or the web is a pressing need shared by researchers and patent attorneys from different chemical disciplines. Retrieval of important chemical information in most cases starts with finding relevant documents for a particular chemical compound or family. Targeted retrieval of chemical documents is closely connected to the automatic recognition of chemical entities in the text, which commonly involves the extraction of the entire list of chemicals mentioned in a document, including any associated information. In this Review, we provide a comprehensive and in-depth description of fundamental concepts, technical implementations, and current technologies for meeting these information demands. A strong focus is placed on community challenges addressing systems performance, more particularly CHEMDNER and CHEMDNER patents tasks of BioCreative IV and V, respectively. Considering the growing interest in the construction of automatically annotated chemical knowledge bases that integrate chemical information and biological data, cheminformatics approaches for mapping the extracted chemical names into chemical structures and their subsequent annotation together with text mining applications for linking chemistry with biological information are also presented. Finally, future trends and current challenges are highlighted as a roadmap proposal for research in this emerging field.A.V. and M.K. acknowledge funding from the European Community’s Horizon 2020 Program (project reference: 654021 - OpenMinted). M.K. additionally acknowledges the Encomienda MINETAD-CNIO as part of the Plan for the Advancement of Language Technology. O.R. and J.O. thank the Foundation for Applied Medical Research (FIMA), University of Navarra (Pamplona, Spain). This work was partially funded by Consellería de Cultura, Educación e Ordenación Universitaria (Xunta de Galicia), and FEDER (European Union), and the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI-01-0145-FEDER-006684). We thank Iñigo Garciá -Yoldi for useful feedback and discussions during the preparation of the manuscript.info:eu-repo/semantics/publishedVersio