8,793 research outputs found
The multi-disciplinary design study: A life cycle cost algorithm
The approach and results of a Life Cycle Cost (LCC) analysis of the Space Station Solar Dynamic Power Subsystem (SDPS) including gimbal pointing and power output performance are documented. The Multi-Discipline Design Tool (MDDT) computer program developed during the 1986 study has been modified to include the design, performance, and cost algorithms for the SDPS as described. As with the Space Station structural and control subsystems, the LCC of the SDPS can be computed within the MDDT program as a function of the engineering design variables. Two simple examples of MDDT's capability to evaluate cost sensitivity and design based on LCC are included. MDDT was designed to accept NASA's IMAT computer program data as input so that IMAT's detailed structural and controls design capability can be assessed with expected system LCC as computed by MDDT. No changes to IMAT were required. Detailed knowledge of IMAT is not required to perform the LCC analyses as the interface with IMAT is noninteractive
Nonlinear wave interaction and spin models in the MHD regime
Here we consider the influence on the electron spin in the MHD regime.
Recently developed models which include spin-velocity correlations are taken as
a starting point. A theoretical argument is presented, suggesting that in the
MHD regime a single fluid electron model with spin correlations is equivalent
to a model with spin-up and spin-down electrons constituting different fluids,
but where the spin-velocity correlations are omitted. Three wave interaction of
2 shear Alfven waves and a compressional Alfven wave is then taken as a model
problem to evaluate the asserted equivalence. The theoretical argument turns
out to be supported, as the predictions of the two models agree completely.
Furthermore, the three wave coupling coefficients obey the Manley-Rowe
relations, which give further support to the soundness of the models and the
validity of the assumptions made in the derivation. Finally we point out that
the proposed two-fluid model can be incorporated in standard Particle-In-Cell
schemes with only minor modifications.Comment: 8 page
High Energy Neutrinos and Photons from Curvature Pions in Magnetars
We discuss the relevance of the curvature radiation of pions in strongly
magnetized pulsars or magnetars, and their implications for the production of
TeV energy neutrinos detectable by cubic kilometer scale detectors, as well as
high energy photons.Comment: 19 pages, 4 figures, to appear in JCA
Bounds on Cross-sections and Lifetimes for Dark Matter Annihilation and Decay into Charged Leptons from Gamma-ray Observations of Dwarf Galaxies
We provide conservative bounds on the dark matter cross-section and lifetime
from final state radiation produced by annihilation or decay into charged
leptons, either directly or via an intermediate particle . Our analysis
utilizes the experimental gamma-ray flux upper limits from four Milky Way dwarf
satellites: HESS observations of Sagittarius and VERITAS observations of Draco,
Ursa Minor, and Willman 1. Using 90% confidence level lower limits on the
integrals over the dark matter distributions, we find that these constraints
are largely unable to rule out dark matter annihilations or decays as an
explanation of the PAMELA and ATIC/PPB-BETS excesses. However, if there is an
additional Sommerfeld enhancement in dwarfs, which have a velocity dispersion
~10 to 20 times lower than that of the local Galactic halo, then the
cross-sections for dark matter annihilating through 's required to
explain the excesses are very close to the cross-section upper bounds from
Willman 1. Dark matter annihilation directly into 's is also marginally
ruled out by Willman 1 as an explanation of the excesses, and the required
cross-section is only a factor of a few below the upper bound from Draco.
Finally, we make predictions for the gamma-ray flux expected from the dwarf
galaxy Segue 1 for the Fermi Gamma-ray Space Telescope. We find that for a
sizeable fraction of the parameter space in which dark matter annihilation into
charged leptons explains the PAMELA excess, Fermi has good prospects for
detecting a gamma-ray signal from Segue 1 after one year of observation.Comment: 11 pages, 4 figures. References added. Final published versio
Strategies to improve retention in randomised trials: a Cochrane systematic review and meta-analysis
Objective: To quantify the effect of strategies to improve retention in randomised trials.<p></p>
Design: Systematic review and meta-analysis.<p></p>
Data sources Sources searched: MEDLINE, EMBASE, PsycINFO, DARE, CENTRAL, CINAHL, C2-SPECTR, ERIC, PreMEDLINE, Cochrane Methodology Register, Current Controlled Trials metaRegister, WHO trials platform, Society for Clinical Trials (SCT) conference proceedings and a survey of all UK clinical trial research units.<p></p>
Review: methods Included trials were randomised evaluations of strategies to improve retention embedded within host randomised trials. The primary outcome was retention of trial participants. Data from trials were pooled using the fixed-effect model. Subgroup analyses were used to explore the heterogeneity and to determine whether there were any differences in effect by the type of strategy.<p></p>
Results: 38 retention trials were identified. Six broad types of strategies were evaluated. Strategies that increased postal questionnaire responses were: adding, that is, giving a monetary incentive (RR 1.18; 95% CI 1.09 to 1.28) and higher valued incentives (RR 1.12; 95% CI 1.04 to 1.22). Offering a monetary incentive, that is, an incentive given on receipt of a completed questionnaire, also increased electronic questionnaire response (RR 1.25; 95% CI 1.14 to 1.38). The evidence for shorter questionnaires (RR 1.04; 95% CI 1.00 to 1.08) and questionnaires relevant to the disease/condition (RR 1.07; 95% CI 1.01 to 1.14) is less clear. On the basis of the results of single trials, the following strategies appeared effective at increasing questionnaire response: recorded delivery of questionnaires (RR 2.08; 95% CI 1.11 to 3.87); a ‘package’ of postal communication strategies (RR 1.43; 95% CI 1.22 to 1.67) and an open trial design (RR 1.37; 95% CI 1.16 to 1.63). There is no good evidence that the following strategies impact on trial response/retention: adding a non-monetary incentive (RR=1.00; 95% CI 0.98 to 1.02); offering a non-monetary incentive (RR=0.99; 95% CI 0.95 to 1.03); ‘enhanced’ letters (RR=1.01; 95% CI 0.97 to 1.05); monetary incentives compared with offering prize draw entry (RR=1.04; 95% CI 0.91 to 1.19); priority postal delivery (RR=1.02; 95% CI 0.95 to 1.09); behavioural motivational strategies (RR=1.08; 95% CI 0.93 to 1.24); additional reminders to participants (RR=1.03; 95% CI 0.99 to 1.06) and questionnaire question order (RR=1.00, 0.97 to 1.02). Also based on single trials, these strategies do not appear effective: a telephone survey compared with a monetary incentive plus questionnaire (RR=1.08; 95% CI 0.94 to 1.24); offering a charity donation (RR=1.02, 95% CI 0.78 to 1.32); sending sites reminders (RR=0.96; 95% CI 0.83 to 1.11); sending questionnaires early (RR=1.10; 95% CI 0.96 to 1.26); longer and clearer questionnaires (RR=1.01, 0.95 to 1.07) and participant case management by trial assistants (RR=1.00; 95% CI 0.97 to 1.04).<p></p>
Conclusions: Most of the trials evaluated questionnaire response rather than ways to improve participants return to site for follow-up. Monetary incentives and offers of monetary incentives increase postal and electronic questionnaire response. Some strategies need further evaluation. Application of these results would depend on trial context and follow-up procedures.<p></p>
Use of strategies to improve retention in primary care randomised trials: a qualitative study with in-depth interviews
Objective To explore the strategies used to improve retention in primary care randomised trials.<p></p>
Design Qualitative in-depth interviews and thematic analysis.<p></p>
Participants 29 UK primary care chief and principal investigators, trial managers and research nurses.<p></p>
Methods In-depth face-to-face interviews.<p></p>
Results Primary care researchers use incentive and communication strategies to improve retention in trials, but were unsure of their effect. Small monetary incentives were used to increase response to postal questionnaires. Non-monetary incentives were used although there was scepticism about the impact of these on retention. Nurses routinely used telephone communication to encourage participants to return for trial follow-up. Trial managers used first class post, shorter questionnaires and improved questionnaire designs with the aim of improving questionnaire response. Interviewees thought an open trial design could lead to biased results and were negative about using behavioural strategies to improve retention. There was consensus among the interviewees that effective communication and rapport with participants, participant altruism, respect for participant's time, flexibility of trial personnel and appointment schedules and trial information improve retention. Interviewees noted particular challenges with retention in mental health trials and those involving teenagers.<p></p>
Conclusions The findings of this qualitative study have allowed us to reflect on research practice around retention and highlight a gap between such practice and current evidence. Interviewees describe acting from experience without evidence from the literature, which supports the use of small monetary incentives to improve the questionnaire response. No such evidence exists for non-monetary incentives or first class post, use of which may need reconsideration. An exploration of barriers and facilitators to retention in other research contexts may be justified.<p></p>
Discovery of Gamma-ray Pulsations from the Transitional Redback PSR J1227-4853
The 1.69 ms spin period of PSR J1227-4853 was recently discovered in radio
observations of the low-mass X-ray binary XSS J12270-4859 following the
announcement of a possible transition to a rotation-powered millisecond pulsar
state, inferred from decreases in optical, X-ray, and gamma-ray flux from the
source. We report the detection of significant (5) gamma-ray pulsations
after the transition, at the known spin period, using ~1 year of data from the
Large Area Telescope on board the Fermi Gamma-ray Space Telescope. The
gamma-ray light curve of PSR J1227-4853 can be fit by one broad peak, which
occurs at nearly the same phase as the main peak in the 1.4 GHz radio profile.
The partial alignment of light-curve peaks in different wavebands suggests that
at least some of the radio emission may originate at high altitude in the
pulsar magnetosphere, in extended regions co-located with the gamma-ray
emission site. We folded the LAT data at the orbital period, both pre- and
post-transition, but find no evidence for significant modulation of the
gamma-ray flux. Analysis of the gamma-ray flux over the mission suggests an
approximate transition time of 2012 November 30. Continued study of the pulsed
emission and monitoring of PSR J1227-4853, and other known redback systems, for
subsequent flux changes will increase our knowledge of the pulsar emission
mechanism and transitioning systems.Comment: 5 figures, 1 table, accepted for publication in ApJ, updated to
reflect accepted version and add additional coautho
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