42 research outputs found
Phase II study of docetaxel in patients with metastatic pancreatic cancer: a Japanese cooperative study
Enyne- and enediyne-y-lactonefrso m the bark of Meiogyne cylindrocarpa
The chemical investigation ofthe EtOAc extract ofthe bark ofMeiogrne qilindrocarpa led to the isolation of two enyne- and five enediynel-lactones, sapranthins A-G (1 -7), of which six were new. They were identified by mass spectrometry,extensive one- and two-dimensional NMR spectroscopya nd through comparison with data reported in the Iiterature.S apranthinsB , C and E (2,3 and 5, respectively showed a weak cytotoxic activity on L1210 with lC50 values comprised between 8.1 and 18.0 µM
Troisième symposium sur les substances naturelles d'intérêt biologique de la région Pacifique-Asie = Third Pacific-Asia symposium on biologically active natural products
Synthesis and biological evaluation of novel compounds related to 1-arylnaphthalene lignans and isoquinolines
Novel compounds designed as hybrids of 1-arylnaphthalene lignans with isoquinoline alkaloids were prepared and evaluated for their cytotoxicities on human tumor cell lines, such as A549, Hela, PC-3, CNE, BEL-7404, and KB. Some of the synthetic compounds exhibited their IC 50 values on selected cell lines at 10 -6 m scale. The preliminary CoMFA molecular-modelling studies of these synthetic analogues were also performed. © 2005 Verlag Helvetica Chimica Acta AG, Zürich.link_to_subscribed_fulltex
Synthesis and cytotoxicity evaluation of some isoquinoline derivatives related to 1-arylnaphthalene lignans
Two series of novel compounds designed as hybrids of 1-arylnaphthalene lignans with dihydroisoquinolines or isoquinolines were synthesized and evaluated for their cytotoxicities on human tumor cell lines, such as A549, Hela, PC-3 and KB. Some of the synthetic compounds exhibited their IC 50 values on selected cell lines at μmol/L scale.link_to_subscribed_fulltex
Synthesis and biological evaluation of novel compounds related to 1-arylnaphthalene lignans and isoquinolines
Novel compounds designed as hybrids of 1-arylnaphthalene lignans with isoquinoline alkaloids were prepared and evaluated for their cytotoxicities on human tumor cell lines, such as A549, Hela, PC-3, CNE, BEL-7404, and KB. Some of the synthetic compounds exhibited their IC 50 values on selected cell lines at 10 -6 m scale. The preliminary CoMFA molecular-modelling studies of these synthetic analogues were also performed. © 2005 Verlag Helvetica Chimica Acta AG, Zürich.link_to_subscribed_fulltex