Locomotor patterns in cerebellar ataxia

Several studies demonstrated how cerebellar ataxia (CA) affects gait, resulting in deficits in multi-joint coordination and stability. Nevertheless, how lesions of cerebellum influence the locomotor muscle pattern generation is still unclear. To better understand the effects of CA on locomotor output, here we investigated the idiosyncratic features of the spatiotemporal structure of leg muscle activity and impairments in the biomechanics of CA gait. To this end, we recorded the electromyographic (EMG) activity of 12 unilateral lower limb muscles and analyzed kinematic and kinetic parameters of 19 ataxic patients and 20 age-matched healthy subjects during overground walking. Neuromuscular control of gait in CA was characterized by a considerable widening of EMG bursts and significant temporal shifts in the center of activity due to overall enhanced muscle activation between late swing and mid-stance. Patients also demonstrated significant changes in the intersegmental coordination, an abnormal transient in the vertical ground reaction force and instability of limb loading at heel strike. The observed abnormalities in EMG patterns and foot loading correlated with the severity of pathology (clinical ataxia scale, ICARS) and the changes in the biomechanical output. The findings provide new insights into the physiological role of cerebellum in optimizing the duration of muscle activity bursts and the control of appropriate foot loading during locomotion

Gait Patterns in Patients with Hereditary Spastic Paraparesis

Spastic gait is a key feature in patients with hereditary spastic paraparesis, but the gait characterization and the relationship between the gait impairment and clinical characteristics have not been investigated

The sensor-based biomechanical risk assessment at the base of the need for revising of standards for human ergonomics

Due to the epochal changes introduced by “Industry 4.0”, it is getting harder to apply the varying approaches for biomechanical risk assessment of manual handling tasks used to prevent work-related musculoskeletal disorders (WMDs) considered within the International Standards for ergonomics. In fact, the innovative human–robot collaboration (HRC) systems are widening the number of work motor tasks that cannot be assessed. On the other hand, new sensor-based tools for biomechanical risk assessment could be used for both quantitative “direct instrumental evaluations” and “rating of standard methods”, allowing certain improvements over traditional methods. In this light, this Letter aims at detecting the need for revising the standards for human ergonomics and biomechanical risk assessment by analyzing the WMDs prevalence and incidence; additionally, the strengths and weaknesses of traditional methods listed within the International Standards for manual handling activities and the next challenges needed for their revision are considered. As a representative example, the discussion is referred to the lifting of heavy loads where the revision should include the use of sensor-based tools for biomechanical risk assessment during lifting performed with the use of exoskeletons, by more than one person (team lifting) and when the traditional methods cannot be applied. The wearability of sensing and feedback sensors in addition to human augmentation technologies allows for increasing workers’ awareness about possible risks and enhance the effectiveness and safety during the execution of in many manual handling activities

Effects of robotic upper limb treatment after stroke on cognitive patterns: A systematic review

BACKGROUND: Robotic therapy (RT) has been internationally recognized for the motor rehabilitation of the upper limb. Although it seems that RT can stimulate and promote neuroplasticity, the effectiveness of robotics in restoring cognitive deficits has been considered only in a few recent studies. OBJECTIVE: To verify whether, in the current state of the literature, cognitive measures are used as inclusion or exclusion criteria and/or outcomes measures in robotic upper limb rehabilitation in stroke patients. METHODS: The systematic review was conducted according to PRISMA guidelines. Studies eligible were identified through PubMed/MEDLINE and Web of Science from inception to March 2021. RESULTS: Eighty-one studies were considered in this systematic review. Seventy-three studies have at least a cognitive inclusion or exclusion criteria, while only seven studies assessed cognitive outcomes. CONCLUSION: Despite the high presence of cognitive instruments used for inclusion/exclusion criteria their heterogeneity did not allow the identification of a guideline for the evaluation of patients in different stroke stages. Therefore, although the heterogeneity and the low percentage of studies that included cognitive outcomes, seemed that the latter were positively influenced by RT in post-stroke rehabilitation. Future larger RCTs are needed to outline which cognitive scales are most suitable and their cut-off, as well as what cognitive outcome measures to use in the various stages of post-stroke rehabilitation

Knowledge extraction based on discourse representation theory and linguistic frames

We have implemented a novel approach for robust ontology design from natural language texts by combining Discourse Representation Theory (DRT), linguistic frame semantics, and ontology design patterns. We show that DRT-based frame detection is feasible by conducting a comparative evaluation of our approach and existing tools. Furthermore, we define a mapping between DRT and RDF/OWL for the production of quality linked data and ontologies, and present FRED, an online tool for converting text into internally well-connected and linked-data-ready ontologies in web-service-acceptable time. \uc2\ua9 2012 Springer-Verlag

Critical issues and imminent challenges in the use of sEMG in return-to-work rehabilitation of patients affected by neurological disorders in the epoch of human–robot collaborative technologies

Patients affected by neurological pathologies with motor disorders when they are of working age have to cope with problems related to employability, difficulties in working, and premature work interruption. It has been demonstrated that suitable job accommodation plans play a beneficial role in the overall quality of life of pathological subjects. A well-designed return-to-work program should consider several recent innovations in the clinical and ergonomic fields. One of the instrument-based methods used to monitor the effectiveness of ergonomic interventions is surface electromyography (sEMG), a multi-channel, non-invasive, wireless, wearable tool, which allows in-depth analysis of motor coordination mechanisms. Although the scientific literature in this field is extensive, its use remains significantly underexploited and the state-of-the-art technology lags expectations. This is mainly attributable to technical and methodological (electrode-skin impedance, noise, electrode location, size, configuration and distance, presence of crosstalk signals, comfort issues, selection of appropriate sensor setup, sEMG amplitude normalization, definition of correct sEMG-related outcomes and normative data) and cultural limitations. The technical and methodological problems are being resolved or minimized also thanks to the possibility of using reference books and tutorials. Cultural limitations are identified in the traditional use of qualitative approaches at the expense of quantitative measurement-based monitoring methods to design and assess ergonomic interventions and train operators. To bridge the gap between the return-to-work rehabilitation and other disciplines, several teaching courses, accompanied by further electrodes and instrumentations development, should be designed at all Bachelor, Master and PhD of Science levels to enhance the best skills available among physiotherapists, occupational health and safety technicians and ergonomists

Otolithic control of anticompensatory fast phases (AFPs) in cats

Anticompensatory fast phases (AFPs) to vestibular step stimulation in the vertical and horizontal planes and spontaneous saccades were recorded in cats in the upright position and 90\ub0 side-down positions. With increasing stimulus velocity, the AFPs of the horizontal vestibulo-ocular reflex (HVOR) increased in cumulative amplitude. AFPs of the vertical VOR (VVOR) were smaller compared to HVOR and showed only a slight increase in cumulative amplitude with increasing stimulus velocity. In contrast, AFP amplitude calculated for VVOR evoked in side-down position increased with increasing velocity as observed for HVOR. AFP direction was aligned with the horizon regardless of both the stimulus plane and animal position. Also the direction of spontaneous saccades tended to be aligned with the horizon. The distribution area of the final points of AFPs was elliptic with the major axis oriented in the horizontal plane. Its projection onto the retina corresponded to the high receptor density area. The ellipse orientation did not change with respect to space up to 30\ub0 of head inclination. Beyond this limit the major axis of the ellipse tended to be progressively less aligned with the horizon. The same trend was observed for spontaneous saccades

Constrained Wiki: The WikiWay to Validating Content

The “WikiWay” is the open editing philosophy of wikis meant to foster open collaboration and continuous improvement of their content. Just like other online communities, wikis often introduce and enforce conventions, constraints, and rules for their content, but do so in a considerably softer way, expecting authors to deliver content that satisfies the conventions and the constraints, or, failing that, having volunteers of the community, the WikiGnomes, fix others' content accordingly. Constrained wikis is our generic framework for wikis to implement validators of community-specific constraints and conventions that preserve the WikiWay and their open collaboration features. To this end, specific requirements need to be observed by validators and a specific software architecture can be used for their implementation, that is, as independent functions (implemented as internal modules or external services) used in a nonintrusive way. Two separate proof-of-concept validators have been implemented for MediaWiki and MoinMoin, respectively, providing an annotated view functions, that is, presenting content authors with violation warnings, rather than preventing them from saving a noncompliant text