2 research outputs found
Evaluation of Novel Synthetic Methods for the Preparation of the Sodium Channel Inhibitor, GW273225X
The evaluation of efficient synthetic
methods for the preparation
of (<i>R</i>)-2,4-diamino-5-(2,3-dichlorophenyl)-6-fluoromethylpyrimidine,
GW273225X (<b>1</b>), is described. The initial synthesis using
ethylfluoroacetate was evaluated against three alternative routes
using either nucleophilic fluorination, electrophilic fluorination,
or sodium fluoroacetate