2,471 research outputs found
Measurement of the B semileptonic branching fraction into excited charm mesons
The territorial dialogue reveals to be, indeed, a process of stake in common of objectives which the group in charge of the territorial organization should share or in any cases which he should make his. Whereas a joint territorial policy can be the actual result of this reflection and opens the actors in a territorial coordination. This coordination is a process rationalizing of vision of the world which applies to the territory. This process collects the actors and transforms them into a collective actor: the practice of the territorial watch participates of this territorial policy joint and introduced in upstream. The territorial dialogue is so preliminary, possibly , in a joint territorial policy. It has for goal to come to an agreement on a territorial vision, and on an explicit gratitude(recognition) of the legitimacy of the actors having power to act on this vision. The recognition and so, the nearness, obtains by a link of the vision which hold the actors
Review of the Laguerre-Gauss mode technology research program at Birmingham
Gravitational wave detectors from the advanced generation onwards are
expected to be limited in sensitivity by thermal noise of the optics, making
the reduction of this noise a key factor in the success of such detectors. A
proposed method for reducing the impact of this noise is to use higher-order
Laguerre-Gauss (LG) modes for the readout beam, as opposed to the currently
used fundamental mode. We present here a synopsis of the research program
undertaken by the University of Birmingham into the suitability of LG mode
technology for future gravitational wave detectors. This will cover our
previous and current work on this topic, from initial simulations and table-top
LG mode experiments up to implementation in a prototype scale suspended cavity
and high-power laser bench
Acculturation and self-reported health among Hispanics using a socio-behavioral model: the North Texas Healthy Heart Study
<p>Abstract</p> <p>Background</p> <p>Acculturation is a continuous, firsthand contact with other cultures functioning at both group and individual levels and is reflected in our culturally diverse society, calling for a greater understanding of the environmental and cultural impact on health. Self-reported health (SRH), a robust and well validated predictor of future mortality for all racial/ethnic groups, has been differentially reported by Hispanics compared to whites, especially based on their acculturation status. This study investigated the relationship between acculturation and SRH among Hispanics. An adapted Andersen framework was used to develop logistic regression models to assess for an association between acculturation and general health status.</p> <p>Methods</p> <p>Hispanic participants (n = 135), as part of the North Texas Healthy Heart Study, were administered standardized questionnaires on acculturation, psychosocial measures which included sense of control, stress, depression and social support and a single item SRH measure. In addition, physiological measurements and demographic characteristics including age, gender, body mass index, medical history, and socioeconomic status were also obtained.</p> <p>Results</p> <p>Bivariate analyses found Mexican-oriented participants 3.16 times more likely to report fair/poor SRH compared to Anglo-oriented Hispanics. Acculturation was also associated with SRH in multiple regression models controlling for enabling, need, and predisposing factors together (OR: 3.53, 95% CI: 1.04, 11.97).</p> <p>Conclusions</p> <p>Acculturation status was associated with SRH after accounting for other underlying factors. Medical and public health professionals should promote the use of acculturation measures in order to better understand its role in Hispanic behaviors, health outcomes and health care use. Such research findings will contribute to the design of culturally sensitive prevention and treatment strategies for diverse and immigrant populations.</p
In-situ characterization of the thermal state of resonant optical interferometers via tracking of their higher-order mode resonances
Thermal lensing in resonant optical interferometers such as those used for
gravitational wave detection is a concern due to the negative impact on control
signals and instrument sensitivity. In this paper we describe a method for
monitoring the thermal state of such interferometers by probing the
higher-order spatial mode resonances of the cavities within them. We
demonstrate the use of this technique to measure changes in the Advanced LIGO
input mode cleaner cavity geometry as a function of input power, and
subsequently infer the optical absorption at the mirror surfaces at the level
of 1 ppm per mirror. We also demonstrate the generation of a useful error
signal for thermal state of the Advanced LIGO power recycling cavity by
continuously tracking the first order spatial mode resonance frequency. Such an
error signal could be used as an input to thermal compensation systems to
maintain the interferometer cavity geometries in the presence of transients in
circulating light power levels, thereby maintaining optimal sensitivity and
maximizing the duty-cycle of the detectors
Principles of practice parameters for the treatment of sleep disordered breathing in the elderly and frail elderly: the consensus of the International Geriatric Sleep Medicine Task Force
Sleep disordered breathing (SDB) is a leading cause of morbidity worldwide. Its prevalence increases with age. Due to the demographic changes in industrial societies, pulmonologists and sleep physicians are confronted with a rapidly growing number of elderly SDB patients. For many physicians, it remains unclear how current guidelines for SDB management apply to elderly and frail elderly patients. The goal of this consensus statement is to provide guidance based on published evidence for SDB treatment in this specific patient group.
Clinicians and researchers with expertise in geriatric sleep medicine representing several countries were invited to participate in a task force. A literature search of PubMed from the past 12 years and a systematic review of evidence of studies deemed relevant was performed.
Recommendations for treatment management of elderly and frail elderly SDB patients based on published evidence were formulated via discussion and consensus.
In the last 12 years, there have been surprisingly few studies examining treatment of SDB in older adults and even fewer in frail older adults. Studies that have been conducted on the management of SDB in the older patient population were rarely stratified for age. Studies in SDB treatment that did include age stratification mainly focused on middle-aged and younger patient groups. Based on the evidence that is available, this consensus statement highlights the treatment forms that can be recommended for elderly SDB patients and encourages treatment of SDB in this large patient group
Small optic suspensions for Advanced LIGO input optics and other precision optical experiments
We report on the design and performance of small optic suspensions developed
to suppress seismic motion of out-of-cavity optics in the Input Optics
subsystem of the Advanced LIGO interferometric gravitational wave detector.
These compact single stage suspensions provide isolation in all six degrees of
freedom of the optic, local sensing and actuation in three of them, and passive
damping for the other three
Betulin Is a Potent Anti-Tumor Agent that Is Enhanced by Cholesterol
Betulinic Acid (BetA) and its derivatives have been extensively studied in the past for their anti-tumor effects, but relatively little is known about its precursor Betulin (BE). We found that BE induces apoptosis utilizing a similar mechanism as BetA and is prevented by cyclosporin A (CsA). BE induces cell death more rapidly as compared to BetA, but to achieve similar amounts of cell death a considerably higher concentration of BE is needed. Interestingly, we observed that cholesterol sensitized cells to BE-induced apoptosis, while there was no effect of cholesterol when combined with BetA. Despite the significantly enhanced cytotoxicity, the mode of cell death was not changed as CsA completely abrogated cell death. These results indicate that BE has potent anti-tumor activity especially in combination with cholesterol
Bistability in Apoptosis by Receptor Clustering
Apoptosis is a highly regulated cell death mechanism involved in many
physiological processes. A key component of extrinsically activated apoptosis
is the death receptor Fas, which, on binding to its cognate ligand FasL,
oligomerize to form the death-inducing signaling complex. Motivated by recent
experimental data, we propose a mathematical model of death ligand-receptor
dynamics where FasL acts as a clustering agent for Fas, which form locally
stable signaling platforms through proximity-induced receptor interactions.
Significantly, the model exhibits hysteresis, providing an upstream mechanism
for bistability and robustness. At low receptor concentrations, the bistability
is contingent on the trimerism of FasL. Moreover, irreversible bistability,
representing a committed cell death decision, emerges at high concentrations,
which may be achieved through receptor pre-association or localization onto
membrane lipid rafts. Thus, our model provides a novel theory for these
observed biological phenomena within the unified context of bistability.
Importantly, as Fas interactions initiate the extrinsic apoptotic pathway, our
model also suggests a mechanism by which cells may function as bistable
life/death switches independently of any such dynamics in their downstream
components. Our results highlight the role of death receptors in deciding cell
fate and add to the signal processing capabilities attributed to receptor
clustering.Comment: Accepted by PLoS Comput Bio
Sensitivity Studies for Third-Generation Gravitational Wave Observatories
Advanced gravitational wave detectors, currently under construction, are
expected to directly observe gravitational wave signals of astrophysical
origin. The Einstein Telescope, a third-generation gravitational wave detector,
has been proposed in order to fully open up the emerging field of gravitational
wave astronomy. In this article we describe sensitivity models for the Einstein
Telescope and investigate potential limits imposed by fundamental noise
sources. A special focus is set on evaluating the frequency band below 10Hz
where a complex mixture of seismic, gravity gradient, suspension thermal and
radiation pressure noise dominates. We develop the most accurate sensitivity
model, referred to as ET-D, for a third-generation detector so far, including
the most relevant fundamental noise contributions.Comment: 13 pages, 7 picture
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