2,463 research outputs found
NASA Light-Emitting Diodes for the Prevention of Oral Mucositis in Pediatric Bone Marrow Transplant Patients
Objective: The purpose of this study was to determine the effects of prophylactic near-infrared light therapy from light-emitting diodes (LEDs) in pediatric bone marrow transplant (BMT) recipients.
Background Data: Oral mucositis (OM) is a frequent side effect of chemotherapy that leads to increased morbidity. Near-infrared light has been shown to produce biostimulatory effects in tissues, and previous results using nearinfrared lasers have shown improvement in OM indices. However, LEDs may hold greater potential for clinical applications.
Materials and Methods: We recruited 32 consecutive pediatric patients undergoing myeloablative therapy in preparation for BMT. Patients were examined by two of three pediatric dentists trained in assessing the Schubert oral mucositis index (OMI) for left and right buccal and lateral tongue mucosal surfaces, while the patients were asked to rate their current left and right mouth pain, left and right xerostomia, and throat pain. LED therapy consisted of daily treatment at a fluence of 4 J/cm2 using a 670-nm LED array held to the left extraoral epithelium starting on the day of transplant, with a concurrent sham treatment on the right. Patients were assessed before BMT and every 2â3 days through posttransplant day 14. Outcomes included the percentage of patients with ulcerative oral mucositis (UOM) compared to historical epidemiological controls, the comparison of left and right buccal pain to throat pain, and the comparison between sides of the buccal and lateral tongue OMI and buccal pain.
Results: The incidence of UOM was 53%, compared to an expected rate of 70â90%. There was also a 48% and 39% reduction of treated left and right buccal pain, respectively, compared to untreated throat pain at about posttransplant day 7 (p \u3c 0.05). There were no significant differences between sides in OMI or pain.
Conclusion: Although more studies are needed, LED therapy appears useful in the prevention of OM in pediatric BMT patients
A Ypt/Rab Effector Complex Containing the Sec1 Homolog Vps33p is Required for Homotypic Vacuole Fusion
Yeast vacuoles undergo priming, docking, and homotypic fusion, although little has been known of the connections between these reactions. Vacuole-associated Vam2p and Vam6p (Vam2/6p) are components of a 65S complex containing SNARE proteins. Upon priming by Sec18p/NSF and ATP, Vam2/6p is released as a 38S subcomplex that binds Ypt7p to initiate docking. We now report that the 38S complex consists of both Vam2/6p and the class C Vps proteins [Reider, S. E. and Emr, S. D. (1997) Mol. Biol. Cell 8, 2307-2327]. This complex includes Vps33p, a member of the Sec1 family of proteins that bind t-SNAREs. We term this 38S complex HOPS, for homotypic fusion and vacuole protein sorting. This unexpected finding explains how Vam2/6p associates with SNAREs and provides a mechanistic link of the class C Vps proteins to Ypt/Rab action. HOPS initially associates with vacuole SNAREs in cis and, after release by priming, hops to Ypt7p, activating this Ypt/Rab switch to initiate docking
Contemplative Science: An Insider's Prospectus
This chapter describes the potential farâreaching consequences of contemplative higher education for the fields of science and medicine
Photoionization Broadening of the 1S-2S Transition in a Beam of Atomic Hydrogen
We consider the excitation dynamics of the two-photon \sts transition in a
beam of atomic hydrogen by 243 nm laser radiation. Specifically, we study the
impact of ionization damping on the transition line shape, caused by the
possibility of ionization of the 2S level by the same laser field. Using a
Monte-Carlo simulation, we calculate the line shape of the \sts transition for
the experimental geometry used in the two latest absolute frequency
measurements (M. Niering {\it et al.}, PRL 84, 5496 (2000) and M. Fischer {\it
et al.}, PRL 92, 230802 (2004)). The calculated line shift and line width are
in excellent agreement with the experimentally observed values. From this
comparison we can verify the values of the dynamic Stark shift coefficient for
the \sts transition for the first time on a level of 15%. We show that the
ionization modifies the velocity distribution of the metastable atoms, the line
shape of the \sts transition, and has an influence on the derivation of its
absolute frequency.Comment: 10 pages, 5 figure
Effect of NASA Light-emitting Diode Irradiation on Wound Healing
Objective: The purpose of this study was to assess the effects of hyperbaric oxygen (HBO) and near-infrared light therapy on wound healing.
Background Data: Light-emitting diodes (LED), originally developed for NASA plant growth experiments in space show promise for delivering light deep into tissues of the body to promote wound healing and human tissue growth. In this paper, we review and present our new data of LED treatment on cells grown in culture, on ischemic and diabetic wounds in rat models, and on acute and chronic wounds in humans.
Materials and Methods: In vitro and in vivo (animal and human) studies utilized a variety of LED wavelength, power intensity, and energy density parameters to begin to identify conditions for each biological tissue that are optimal for biostimulation.
Results: LED produced in vitro increases of cell growth of 140â200% in mouse-derived fibroblasts, rat-derived osteoblasts, and rat-derived skeletal muscle cells, and increases in growth of 155â171% of normal human epithelial cells. Wound size decreased up to 36% in conjunction with HBO in ischemic rat models. LED produced improvement of greater than 40% in musculoskeletal training injuries in Navy SEAL team members, and decreased wound healing time in crew members aboard a U.S. Naval submarine. LED produced a 47% reduction in pain of children suffering from oral mucositis.
Conclusion: We believe that the use of NASA LED for light therapy alone, and in conjunction with hyperbaric oxygen, will greatly enhance the natural wound healing process, and more quickly return the patient to a preinjury/ illness level of activity. This work is supported and managed through the NASA Marshall Space Flight CenterâSBIR Program
Precision spectroscopy with two correlated atoms
We discuss techniques that allow for long coherence times in laser
spectroscopy experiments with two trapped ions. We show that for this purpose
not only entangled ions prepared in decoherence-free subspaces can be used but
also a pair of ions that are not entangled but subject to the same kind of
phase noise. We apply this technique to a measurement of the electric
quadrupole moment of the 3d D5/2 state of 40Ca+ and to a measurement of the
linewidth of an ultrastable laser exciting a pair of 40Ca+ ions
Fundamental Physical Constants: Looking from Different Angles
We consider fundamental physical constants which are among a few of the most
important pieces of information we have learned about Nature after its
intensive centuries-long studies. We discuss their multifunctional role in
modern physics including problems related to the art of measurement, natural
and practical units, origin of the constants, their possible calculability and
variability etc
Optical Clocks in Space
The performance of optical clocks has strongly progressed in recent years,
and accuracies and instabilities of 1 part in 10^18 are expected in the near
future. The operation of optical clocks in space provides new scientific and
technological opportunities. In particular, an earth-orbiting satellite
containing an ensemble of optical clocks would allow a precision measurement of
the gravitational redshift, navigation with improved precision, mapping of the
earth's gravitational potential by relativistic geodesy, and comparisons
between ground clocks.Comment: Proc. III International Conference on Particle and Fundamental
Physics in Space (SpacePart06), Beijing 19 - 21 April 2006, to appear in
Nucl. Phys.
'Designer atoms' for quantum metrology
Entanglement is recognized as a key resource for quantum computation and
quantum cryptography. For quantum metrology, the use of entangled states has
been discussed and demonstrated as a means of improving the signal-to-noise
ratio. In addition, entangled states have been used in experiments for
efficient quantum state detection and for the measurement of scattering
lengths. In quantum information processing, manipulation of individual quantum
bits allows for the tailored design of specific states that are insensitive to
the detrimental influences of an environment. Such 'decoherence-free subspaces'
protect quantum information and yield significantly enhanced coherence times.
Here we use a decoherence-free subspace with specifically designed entangled
states to demonstrate precision spectroscopy of a pair of trapped Ca+ ions; we
obtain the electric quadrupole moment, which is of use for frequency standard
applications. We find that entangled states are not only useful for enhancing
the signal-to-noise ratio in frequency measurements - a suitably designed pair
of atoms also allows clock measurements in the presence of strong technical
noise. Our technique makes explicit use of non-locality as an entanglement
property and provides an approach for 'designed' quantum metrology
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