Antigen-driven clonal proliferation of B cells within the target tissue of an autoimmune disease: the salivary glands of patients with Sjögren's syndrome

Structures resembling germinal centers are seen in the salivary glands of patients with Sjögren's syndrome, but it is not known whether the microenvironment of these cell clusters is sufficient for the induction of a germinal center response. Therefore, we cloned and sequenced rearranged Ig V genes expressed by B cells isolated from sections of labial salivary gland biopsies from two Sjögren's syndrome patients. Rearranged V genes from B cells within one cell cluster were polyclonal and most had few somatic mutations. Two adjacent clusters from another patient each contained one dominant B cell clone expressing hypermutated V genes. None of the rearranged V genes was found in both clusters, suggesting that cells are unable to migrate out into the surrounding tissue and seed new clusters. The ratios of replacement to silent mutations in the framework and complementarity determining regions suggest antigen selection of high-affinity mutants. These results show that an antigen-driven, germinal center-type B cell response is taking place within the salivary glands of Sjögren's syndrome patients. In view of the recent demonstration of a germinal center response within the rheumatoid synovial membrane and the existence of similar structures in the target tissues of other autoimmune. diseases, we propose that germinal center- type responses can be induced in the nonlymphoid target tissues of a variety of autoimmune diseases

Early correlates of error-related brain activity predict subjective timing of error awareness

Humans are remarkably reliable in detecting errors in their behavior. Whereas error awareness has been assumed to emerge not until 200–400 ms after an error, the so-called early error sensations refer to the subjective feeling of having detected an error even before the erroneous response was executed. Here, we collected electroencephalogram (EEG) to track how early error sensations are reflected in neural correlates of performance monitoring. Participants first had to perform a task, and then had to indicate whether an error has occurred and whether this error was detected before or after response execution. EEG results showed that early error sensations were associated with an earlier peak of the error-related negativity (Ne/ERN), a component of error-related brain activity that occurs briefly after the error response. This demonstrates that early error-related activity influences metacognitive judgments on the time course of error awareness, and thus contributes to error awareness

Are errors detected before they occur? Early error sensations revealed by metacognitive judgments on the timing of error awareness

Errors in choice tasks are not only detected fast and reliably, participants often report that they knew that an error occurred already before a response was produced. These early error sensations stand in contrast with evidence suggesting that the earliest neural correlates of error awareness emerge around 300 ms after erroneous responses. The present study aimed to investigate whether anecdotal evidence for early error sensations can be corroborated in a controlled study in which participants provide metacognitive judgments on the subjective timing of error awareness. In Experiment 1, participants had to report whether they became aware of their errors before or after the response. In Experiment 2, we measured confidence in these metacognitive judgments. Our data show that participants report early error sensations with high confidence in the majority of error trials across paradigms and experiments. These results provide first evidence for early error sensations, informing theories of error awareness

Error-related cardiac deceleration: Functional interplay between error-related brain activity and autonomic nervous system in performance monitoring

Coordinated interactions between the central and autonomic nervous systems are crucial for survival due to the inherent propensity for human behavior to make errors. In our ever-changing environment, when individuals make mistakes, these errors can have life-threatening consequences. In response to errors, specific reactions occur in both brain activity and heart rate to detect and correct errors. Specifically, there are two brain-related indicators of error detection and awareness known as error-related negativity and error positivity. Conversely, error-related cardiac deceleration denotes a momentary slowing of heart rate following an error, signaling an autonomic response. However, what is the connection between the brain and the heart during error processing? In this review, we discuss the functional and neuroanatomical connections between the brain and heart markers of error processing, exploring the experimental conditions in which they covary. Given the current limitations of available data, future research will continue to investigate the neurobiological factors governing the brain-heart interaction, aiming to utilize them as combined markers for assessing cognitive control in healthy and pathological conditions

Finite top quark mass effects in NNLO Higgs boson production at LHC

We present next-to-next-to-leading order corrections to the inclusive production of the Higgs bosons at the CERN Large Hadron Collider (LHC) including finite top quark mass effects. Expanding our analytic results for the partonic cross section around the soft limit we find agreement with a very recent publication by Harlander and Ozeren \cite{Harlander:2009mq}.Comment: 15 page

Physics Behind Precision

This document provides a writeup of contributions to the FCC-ee mini-workshop on "Physics behind precision" held at CERN, on 2-3 February 2016.Comment: https://indico.cern.ch/event/469561

Precise predictions for Higgs production in models with color-octet scalars

We describe an effective-theory computation of the next-to-next-to-leading order (NNLO) QCD corrections to the gluon-fusion production of a Higgs boson in models with massive color-octet scalars in the (8,1)_0 representation. Numerical results are presented for both the Tevatron and the LHC. The estimated theoretical uncertainty is greatly reduced by the inclusion of the NNLO corrections. Color-octet scalars can increase the Standard Model rate by more than a factor of two in allowed regions of parameter space.Comment: 6 pages, 5 figures, to appear in the proceedings of the "10th DESY Workshop on Elementary Particle Theory: Loops and Legs in Quantum Field Theory", Woerlitz, Germany, April 25-30, 201

Three-loop \beta-functions for top-Yukawa and the Higgs self-interaction in the Standard Model

We analytically compute the dominant contributions to the \beta-functions for the top-Yukawa coupling, the strong coupling and the Higgs self-coupling as well as the anomalous dimensions of the scalar, gluon and quark fields in the unbroken phase of the Standard Model at three-loop level. These are mainly the QCD and top-Yukawa corrections. The contributions from the Higgs self-interaction which are negligible for the running of the top-Yukawa and the strong coupling but important for the running of the Higgs self-coupling are also evaluated.Comment: 22 pages, 7 figures. Few extra citations are added; the plots are improved. Results in computer readable form can be retrieved from http://www-ttp.particle.uni-karlsruhe.de/Progdata/ttp12/ttp12-012

Bˉ→Xsγ\bar{B}\to X_s \gamma in the Two Higgs Doublet Model up to Next-to-Next-to-Leading Order in QCD

We compute three-loop matching corrections to the Wilson coefficients $C_7$ and $C_8$ in the Two Higgs Doublet Model by applying expansions for small, intermediate and large charged Higgs boson masses. The results are used to evaluate the branching ratio of $\bar{B}\to X_s \gamma$ to next-to-next-to leading order accuracy, and to determine an updated lower limit on the charged Higgs boson mass. We find \mhplus \ge 380 GeV at 95% confidence level when the recently completed BABAR data analysis is taken into account. Our results for the charged Higgs contribution to the branching ratio exhibit considerably weaker sensitivity to the matching scale $\mu_0$, as compared to previous calculations.Comment: 20 pages, 15 figures; v2: minor modifications, matches published version in JHE

Cosmological implications of the Higgs mass measurement

We assume the validity of the Standard Model up to an arbitrary high-energy scale and discuss what information on the early stages of the Universe can be extracted from a measurement of the Higgs mass. For Mh < 130 GeV, the Higgs potential can develop an instability at large field values. From the absence of excessive thermal Higgs field fluctuations we derive a bound on the reheat temperature after inflation as a function of the Higgs and top masses. Then we discuss the interplay between the quantum Higgs fluctuations generated during the primordial stage of inflation and the cosmological perturbations, in the context of landscape scenarios in which the inflationary parameters scan. We show that, within the large-field models of inflation, it is highly improbable to obtain the observed cosmological perturbations in a Universe with a light Higgs. Moreover, independently of the inflationary model, the detection of primordial tensor perturbations through the B-mode of CMB polarization and the discovery of a light Higgs can simultaneously occur only with exponentially small probability, unless there is new physics beyond the Standard Model.Comment: 28 LaTeX pages, 6 figure