The Development of Regulatory Standards for Gene Therapy in the European Union

This note examines the EU\u27s efforts to regulate gene therapy, considering the Union\u27s resolve to establish scientifically, economically, and morally sound parameters acceptable to its varied constituency. This includes discussion of legal and ethical considerations, biotechnology goals in the EU, and EU-wide uniform regulations

Parton-shower effects on Higgs boson production via vector-boson fusion in association with three jets

We present an implementation of Higgs boson production via vector-boson fusion in association with three jets at hadron colliders in the POWHEG-BOX, a framework for the matching of NLO-QCD calculations with parton-shower programs. Our work provides the means to precisely describe the properties of extra jet activity in vector-boson fusion reactions that are used for the suppression of QCD backgrounds by central jet veto techniques. For a representative setup at the CERN LHC we verify that uncertainties related to parton-shower effects are mild for distributions related to the third jet, in contrast to what has been observed in calculations based on vector-boson fusion induced Higgs production in association with two jets.Comment: 12 pages, 8 figure

Absorption of High Energy Gamma-Rays by Low Energy Intergalactic Photons

Following our previously proposed technique, we have used the recent gamma-ray observations of Mrk 421 to place theoretically significant constraints on and possible estimates of the intergalactic infrared radiation field (IIRF) which are consistent with normal galactic IR production by stars and dust and rule out exotic mechanisms proposed to produce a larger IIRF. Using models for the low energy intergalactic photon spectrum from microwave to UV energies, we calculate the opacity of inter- galactic space to gamma-rays as a function of energy and redshift. These calculations indicate that the GeV gamma-ray burst recently observed by the EGRET experiment on CGRO originates at a redshift less than approximately 1.5.Comment: 12 pg., uuencoded, Z-compressed ps file (includes figures), To be published in Space Sci. Re

Security analysis of the micro transport protocol with a misbehaving receiver

BitTorrent is the most widely used Peer-to-Peer (P2P) protocol and it comprises the largest share of traffic in Europe. To make BitTorrent more Internet Service Provider (ISP) friendly, BitTorrent Inc. invented the Micro Transport Protocol (uTP). It is based on UDP with a novel congestion control called Low Extra Delay Background Transport (LEDBAT). This protocol assumes that the receiver always gives correct feedback, since otherwise this deteriorates throughput or yields to corrupted data. We show through experimental investigation that a misbehaving uTP receiver, which is not interested in data integrity, can increase the bandwidth of the sender by up to five times. This can cause a congestion collapse and steal large share of a victim’s bandwidth. We present three attacks, which increase the bandwidth usage significantly. We have tested these attacks in a real world environment and show its severity both in terms of number of packets and total traffic generated. We also present a countermeasure for protecting against the attacks and evaluate the performance of that defence strategy

Periodic Modulations in an X-ray Flare from Sagittarius A*

We present the highly significant detection of a quasi-periodic flux modulation with a period of 22.2 min seen in the X-ray data of the Sgr A* flare of 2004 August 31. This flaring event, which lasted a total of about three hours, was detected simultaneously by EPIC on XMM-Newton and the NICMOS near-infrared camera on the HST. Given the inherent difficulty in, and the lack of readily available methods for quantifying the probability of a periodic signal detected over only several cycles in a data set where red noise can be important, we developed a general method for quantifying the likelihood that such a modulation is indeed intrinsic to the source and does not arise from background fluctuations. We here describe this Monte Carlo based method, and discuss the results obtained by its application to a other XMM-Newton data sets. Under the simplest hypothesis that we witnessed a transient event that evolved, peaked and decayed near the marginally stable orbit of the supermassive black hole, this result implies that for a mass of 3.5 x 10^{6} Msun, the central object must have an angular momentum corresponding to a spin parameter of a=0.22.Comment: 4 pages, 6 figures, submitted to ApJ

Epiplastral and geographic variation in Echmatemys, a geoemydid turtle from the Eocene of North America: A multi-tiered analysis of epiplastral shape complexity

Numerous geoemydid turtle fossils from the extinct genus Echmatemys have been recovered from the middle Eocene Uinta Formation, Uinta Basin, Utah over the past several decades. Here, we tested whether co-occurring Uintan species Echmatemys callopyge and E. uintensis can be reliably differentiated based on epiplastral morphology, and whether their geospatial distributions overlapped significantly. The geographic spatial and stratigraphic distributions of Uinta Basin E. callopyge and E. uintensis specimens were compared using ArcGIS and analysis of variance (ANOVA). The analysis revealed overlapping geographic distributions of these two species, and no significant differences in stratigraphic dispersal. This finding of extensive geospatial overlap between the two Uintan Echmatemys species highlights the need for accurate taxonomic identification, such as the gular scale morphology validated here. In addition, we sought to address a methodological question regarding the relative efficacy of data complexity in this context. Using epiplastra from three additional Eocene species of Echmatemys, we employed hierarchical analyses of increasing data complexity, from standard linear dimensions to 2D geometric morphometrics to 3D laser scans, to determine the degree to which data complexity contributes to taxonomic assessments within this genus. Uintan species E. callopyge and E. uintensis were found to differ significantly in epiplastral shape as captured by all three categories of data. These findings verify that these two co-occurring species can be differentiated consistently using the shape of the gular scale, and that the use of geometric morphometrics can improve identification of fragmentary specimens. Among the non-Uintan species, dorsal and ventral 2D landmark data reliably differentiated among species, but the linear dimensions were less useful

The incidence of mid-infrared excesses in G and K giants

Using photometric data from the 2MASS and GLIMPSE catalogues, I investigate the incidence of mid-infrared excesses (~10 microns) of G and K stars of luminosity class III. In order to obtain a large sample size, stars are selected using a near-IR colour-magnitude diagram. Sources which are candidates for showing mid-IR excess are carefully examined and modelled to determined whether they are likely to be G/K giants. It is found that mid-IR excesses are present at a level of (1.8 +/- 0.4) x 10^-3. While the origin of these excesses remains uncertain, it is plausible that they arise from debris discs around these stars. I note that the measured incidence is consistent with a scenario in which dust lifetimes in debris discs are determined by Poynting-Robertson drag rather than by collisions.Comment: Accepted for publication in MNRAS. 13 pages, 5 figures, 2 tables (1 landscape table