Letter from Haynes Poll Room Owner F. H. Huggins to Attorney General Langer Regarding What Malt Beverages May Be Sold, 1917

Letter dated July 16, 1917 from F. H. Huggins, proprieter of Haynes Pool Room and Barber Shop in Haynes, ND to Attorney General William Langer asking what kind of malt isn\u27t to be sold in North Dak [sic], adding that he always tries to be a law-abiding citizen.https://commons.und.edu/langer-papers/1271/thumbnail.jp

Solid state television camera system Patent

Solid state television camera system consisting of monolithic semiconductor mosaic sensor and molecular digital readout system

Speech Communication

Contains three reports on research facilities and systems.U. S. Air Force Cambridge Research Laboratories, Office of Aerospace Research, under Contract F19628-69-C-0044National Institutes of Health (Grant 2 ROl NB-04332-06

Polarization of superfluid turbulence

We show that normal fluid eddies in turbulent helium II polarize the tangle of quantized vortex lines present in the flow, thus inducing superfluid vorticity patterns similar to the driving normal fluid eddies. We also show that the polarization is effective over the entire inertial range. The results help explain the surprising analogies between classical and superfluid turbulence which have been observed recently.Comment: 3 figure

The flip-graph of the 4-dimensional cube is connected

Flip-graph connectedness is established here for the vertex set of the 4-dimensional cube. It is found as a consequence that this vertex set has 92 487 256 triangulations, partitioned into 247 451 symmetry classes.Comment: 20 pages, 3 figures, revised proofs and notation

A principled approach to the measurement of situation awareness in commercial aviation

The issue of how to support situation awareness among crews of modern commercial aircraft is becoming especially important with the introduction of automation in the form of sophisticated flight management computers and expert systems designed to assist the crew. In this paper, cognitive theories are discussed that have relevance for the definition and measurement of situation awareness. These theories suggest that comprehension of the flow of events is an active process that is limited by the modularity of attention and memory constraints, but can be enhanced by expert knowledge and strategies. Three implications of this perspective for assessing and improving situation awareness are considered: (1) Scenario variations are proposed that tax awareness by placing demands on attention; (2) Experimental tasks and probes are described for assessing the cognitive processes that underlie situation awareness; and (3) The use of computer-based human performance models to augment the measures of situation awareness derived from performance data is explored. Finally, two potential example applications of the proposed assessment techniques are described, one concerning spatial awareness using wide field of view displays and the other emphasizing fault management in aircraft systems

Site Selective Antibody-Oligonucleotide Conjugation via Microbial Transglutaminase.

Nucleic Acid Therapeutics (NATs), including siRNAs and AntiSense Oligonucleotides (ASOs), have great potential to drug the undruggable genome. Targeting siRNAs and ASOs to specific cell types of interest has driven dramatic improvement in efficacy and reduction in toxicity. Indeed, conjugation of tris-GalNAc to siRNAs and ASOs has shown clinical efficacy in targeting diseases driven by liver hepatocytes. However, targeting non-hepatic diseases with oligonucleotide therapeutics has remained problematic for several reasons, including targeting specific cell types and endosomal escape. Monoclonal antibody (mAb) targeting of siRNAs and ASOs has the potential to deliver these drugs to a variety of specific cell and tissue types. However, most conjugation strategies rely on random chemical conjugation through lysine or cysteine residues resulting in conjugate heterogeneity and a distribution of Drug:Antibody Ratios (DAR). To produce homogeneous DAR-2 conjugates with two siRNAs per mAb, we developed a novel two-step conjugation procedure involving microbial transglutaminase (MTGase) tagging of the antibody C-terminus with an azide-functionalized linker peptide that can be subsequently conjugated to dibenzylcyclooctyne (DBCO) bearing oligonucleotides through azide-alkyne cycloaddition. Antibody-siRNA (and ASO) conjugates (ARCs) produced using this strategy are soluble, chemically defined targeted oligonucleotide therapeutics that have the potential to greatly increase the number of targetable cell types

Beyond Patient Reported Pain: Perfusion Magnetic Resonance Imaging Demonstrates Reproducible Cerebral Representation of Ongoing Post-Surgical Pain

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

VLA Observations of H I in the Helix Nebula (NGC 7293)

We report the detection of 21-cm line emission from H I in the planetary nebula NGC 7293 (the Helix). The observations, made with the Very Large Array, show the presence of a ring of atomic hydrogen that is associated with the outer portion of the ionized nebula. This ring is most probably gas ejected in the AGB phase that has been subsequently photodissociated by radiation from the central star. The H I emission spreads over about 50 km/s in radial velocity. The mass in H I is approximately 0.07 solar masses, about three times larger than the mass in molecular hydrogen and comparable with the mass in ionized hydrogen.Comment: 19 pages, 9 figure