Multidecadal warming of Antarctic waters

Decadal trends in the properties of seawater adjacent to Antarctica are poorly known, and the mechanisms responsible for such changes are uncertain. Antarctic ice sheet mass loss is largely driven by ice shelf basal melt, which is influenced by ocean-ice interactions and has been correlated with Antarctic Continental Shelf Bottom Water (ASBW) temperature. We document the spatial distribution of long-term large-scale trends in temperature, salinity, and core depth over the Antarctic continental shelf and slope. Warming at the seabed in the Bellingshausen and Amundsen seas is linked to increased heat content and to a shoaling of the mid-depth temperature maximum over the continental slope, allowing warmer, saltier water greater access to the shelf in recent years. Regions of ASBW warming are those exhibiting increased ice shelf melt

SKA HI end2end simulation

The current status of the HI simulation efforts is presented, in which a self consistent simulation path is described and basic equations to calculate array sensitivities are given. There is a summary of the SKA Design Study (SKADS) sky simulation and a method for implementing it into the array simulator is presented. A short overview of HI sensitivity requirements is discussed and expected results for a simulated HI survey are presented.Comment: 7 pages, 6 figues, need skads2009.cls file to late

Health sector decentralization and Indonesia ' s nutrition programs : opportunities and challenges

This policy concept paper is intended to assist the center in navigating the tension between opportunities and challenges as activities are adapted to the decentralized national nutrition policy, and to help guide districts and provinces in the conduct o f locally appropriate nutrition programs. The paper synthesizes the findings of an extensive study undertaken by the World Bank with a summary of the results, while the conclusions are discussed in detail in the four annexes. It begins with a review of the accomplishments and remaining nutrition challenges for Indonesia. It then turns to look at the regional diversity in Indonesia ' s nutrition challenges and asks which type of nutrition programs are most cost-effective. The paper concludes with an assessment of the existing institutional arrangement for nutrition service delivery, and discusses steps Indonesia can take to further improve population nutrition and health. The annexes provide extensive data and analysis to shed light on the opportunities and challenges in the new institutional environment.Health Monitoring & Evaluation,Nutrition,Early Child and Children ' s Health,Population Policies,Rural Development Knowledge & Information Systems

Culture expansion in low-glucose conditions preserves chondrocyte differentiation and enhances their subsequent capacity to form cartilage tissue in three-dimensional culture.

Culture conditions that preserve a stable chondrocyte phenotype are desirable in cell-based cartilage repair to maximize efficacy and clinical outcome. This study investigates whether low-glucose conditions will preserve the chondrocyte phenotype during culture expansion. Articular chondrocytes were culture-expanded in media supplemented with either low (1 mM) or high (10 mM) glucose. The metabolic phenotype, reactive oxygen species generation, and mRNA expression of markers of differentiation or catabolism were assessed by reverse-transcription quantitative polymerase chain reaction after four population doublings (PDs) and subsequent tissue formation capacity determined using pellet cultures. Continuous monolayer culture was used to determine the population doubling limit. After expansion in monolayer for four PDs, chondrocytes expanded in low-glucose conditions exhibited higher expression of the differentiation markers SOX9 and COL2A1 and reduced expression of the catabolic metalloproteinase matrix metallopeptidase 13. When chondrocytes expanded in low glucose were cultured in micropellets, they consistently generated more cartilaginous extracellular matrix than those expanded in high glucose, as evaluated by wet weight, sulfated glycosaminoglycan content, and hydroxyproline assay for collagen content. The same pattern was observed whether high or low glucose was used during the pellet culture. During expansion, chondrocytes in high-glucose generated 50% more reactive oxygen species than low-glucose conditions, despite a lower dependence on oxidative phosphorylation for energy. Furthermore low-glucose cells exhibited >30% increased population doubling limit. These data suggests that low-glucose expansion conditions better preserve the expression of differentiation markers by chondrocytes and enhance their subsequent capacity to form cartilage in vitro. Therefore, low glucose levels should be considered for the expansion of chondrocytes intended for tissue engineering applications.This study was funded by the Medical Research Council/Engineering and Physical Sciences Research Council (EPSRC) discipline bridging initiative grant PPA026, EPSRC Platform Grant EP/E046975/1; Human Frontier Science Program Grant RGP0025/2009-C and Arthritis Research U.K. grants 19654 and 19344

The Population of the Galactic Center Filaments: Position Angle Distribution Reveal a Degree-scale Collimated Outflow from Sgr A* along the Galactic Plane

We have examined the distribution of the position angle (PA) of the Galactic center filaments with lengths $L > 66''$ and $< 66''$ as well as their length distribution as a function of PA. We find bimodal PA distributions of the filaments, long and short populations of radio filaments. Our PA study shows the evidence for a distinct population of short filaments with PA close to the Galactic plane. Mainly thermal short radio filaments ($<66''$) have PAs concentrated close to the Galactic plane within $60^\circ < \rm PA <120^\circ$. Remarkably, the short filament PAs are radial with respect to the Galactic center at $l <0^\circ$, and extend in the direction toward Sgr A*. On a smaller scale, the prominent Sgr E HII complex G358.7-0.0 provides a vivid example of the nearly radial distribution of short filaments. The bimodal PA distribution suggests different origin for two distinct filament populations. We argue that alignment of the short filament population results from the ram pressure of a degree-scale outflow from Sgr A* that exceeds the internal filament pressure, and aligns them along the Galactic plane. The ram pressure is estimated to be 2$\times10^6\,$ cm$^{-3}\,$ K at a distance of 300pc, requiring biconical mass outflow rate $10^{-4}$ \msol\, yr$^{-1}$ with an opening angle of $\sim40^\circ$. This outflow aligns not only the magnetized filaments along the Galactic plane but also accelerates thermal material associated with embedded or partially embedded clouds. This places an estimate of $\sim$6 Myr as the age of the outflow.Comment: 19 pages, 8 figures, ApJL (June 2nd, 2023

Parallel pair-wise interaction for multi-agent immune systems modelling

Agent Based Modelling (ABM), is an approach for modelling dynamic systems and studying complex and emergent behaviour. ABM approach is a very common technique in biological domain due to high demand for a large scale analysis tool to collect and interpret information to solve biological problems. However, simulating large scale cellular level models (i.e. large number of agents/entities) require a high degree of computational power which is achievable through parallel computing methods such as Graphics Processing Units (GPUs). The use of parallel approaches in ABMs is growing rapidly specifically when modelling in continuous space system (particle based). Parallel implementation of particle based simulation within continuum space where agents contain quantities of chemicals/substances is very challenging. Pair-wise interactions are different abstraction to continuous space (particle) models which is commonly used for immune system modelling. This paper describes an approach to parallelising the key component of biological and immune system models (pair-wise interactions) within an ABM model. Our performance results demonstrate the applicability of this method to a broader class of biological systems with the same type of cell interactions and that it can be used as the basis for developing complete immune system models on parallel hardware

Developing a quality assurance metric: a panoptic view

This article is a post-print of the published article that may be accessed at the link below. Copyright @ 2006 Sage Publications.There are a variety of techniques that lecturers can use to get feedback on their teaching - for example, module feedback and coursework results. However, a question arises about how reliable and valid are the content that goes into these quality assurance metrics. The aim of this article is to present a new approach for collecting and analysing qualitative feedback from students that could be used as the first stage in developing more reliable quality assurance metrics. The approach, known as the multi-dimensional crystal view, is based on the belief that individuals have different views on the benefits that the embedded process in a system can have on the behaviour of the system. The results of this study indicate that in the context of evaluation and feedback methods, the multi-dimensional approach appears to provide the opportunity for developing more effective student feedback mechanisms