The Signature of Large Scale Structures on the Very High Energy Gamma-Ray Sky

If the diffuse extragalactic gamma ray emission traces the large scale structures of the universe, peculiar anisotropy patterns are expected in the gamma ray sky. In particular, because of the cutoff distance introduced by the absorption of 0.1-10 TeV photons on the infrared/optical background, prominent correlations with the local structures within a range of few hundreds Mpc should be present. We provide detailed predictions of the signal based on the PSCz map of the local universe. We also use mock N-body catalogues complemented with the halo model of structures to study some statistical features of the expected signatures. The results are largely independent from cosmological details, and depend mostly on the index of correlation (or bias) of the sources with respect to the large scale distribution of galaxies. For instance, the predicted signal in the case of a quadratic correlation (as it may happen for a dark matter annihilation contribution to the diffuse gamma flux) differs substantially from a linear correlation case, providing a complementary tool to unveil the nature of the sources of the diffuse gamma ray emission. The chances of the present and future space and ground based observatories to measure these features are discussed.Comment: 26 pages, 9 figures; matches published versio

NF-KappaB expression correlates with apoptosis and angiogenesis in clear cell renal cell carcinoma tissues

<p>Abstract</p> <p>Background</p> <p>Clear cell renal cell carcinoma (ccRCC) is the most frequently encountered tumor in the adult kidney. Many factors are known to take part in the development and progression of this tumor. Nuclear factor kappa B (NF-κB) is a family of the genes that includes five members acting in events such as inflammation and apoptosis. In this study, the role of NF-κB (p50 subunit) in ccRCC and its relation to angiogenesis and apoptosis were investigated.</p> <p>Methods</p> <p>Formalin-fixed and paraffin embedded tissue blocks from 40 patients with ccRCC were studied. Expressions of NF-κB (p50), VEGF, EGFR, bc1-2 and p53 were detected immunohistochemically. The relationship of NF-κB with these markers and clinicopathological findings were evaluated.</p> <p>Results</p> <p>The expression of NF-κB was detected in 35 (85%), VEGF in 37 (92.5%), EGFR in 38 (95%), bc1-2 in 33 (82.5%) and p53 in 13 (32.5%) of 40 ccRCC patients. Statistical analyses revealed a significant relation between NF-κB expression and VEGF (p = 0.001), EGFR (p = 0.004), bc1-2 (p = 0.010) and p53 (p = 0.037). There was no significant correlation between NF-κB and such parameters as tumor grade, stage, age and sex.</p> <p>Conclusion</p> <p>The results of this study indicated that in ccRCC cases NF-κB was associated with markers of angiogenesis and apoptosis such as VEGF, EGFR, bc1-2 and p53. In addition, the results did not only suggest a close relationship between NF-κB and VEGF, EGFR, bc1-2 and p53 in ccRCC, but also indicate that NF-κB was a potential therapeutic target in the treatment of ccRCC resistant to chemotherapy.</p

Outline of Fungi and fungus-like taxa

This article provides an outline of the classification of the kingdom Fungi (including fossil fungi. i.e. dispersed spores, mycelia, sporophores, mycorrhizas). We treat 19 phyla of fungi. These are Aphelidiomycota, Ascomycota, Basidiobolomycota, Basidiomycota, Blastocladiomycota, Calcarisporiellomycota, Caulochytriomycota, Chytridiomycota, Entomophthoromycota, Entorrhizomycota, Glomeromycota, Kickxellomycota, Monoblepharomycota, Mortierellomycota, Mucoromycota, Neocallimastigomycota, Olpidiomycota, Rozellomycota and Zoopagomycota. The placement of all fungal genera is provided at the class-, order- and family-level. The described number of species per genus is also given. Notes are provided of taxa for which recent changes or disagreements have been presented. Fungus-like taxa that were traditionally treated as fungi are also incorporated in this outline (i.e. Eumycetozoa, Dictyosteliomycetes, Ceratiomyxomycetes and Myxomycetes). Four new taxa are introduced: Amblyosporida ord. nov. Neopereziida ord. nov. and Ovavesiculida ord. nov. in Rozellomycota, and Protosporangiaceae fam. nov. in Dictyosteliomycetes. Two different classifications (in outline section and in discussion) are provided for Glomeromycota and Leotiomycetes based on recent studies. The phylogenetic reconstruction of a four-gene dataset (18S and 28S rRNA, RPB1, RPB2) of 433 taxa is presented, including all currently described orders of fungi

Nurses' perceptions of aids and obstacles to the provision of optimal end of life care in ICU

Contains fulltext : 172380.pdf (publisher's version ) (Open Access

Computational study for natural convection effects on temperature during batch and continuous industrial scale radio frequency tempering/thawing processes

Radio frequency (RF) processing have been used for tempering and thawing. There have been significant experimental and mathematical model based studies for this process especially in the last two decades. The modeling studies applied the convective boundary condition with effective heat transfer coefficient and constant medium temperature in through field flat plate RF systems. The objective of this study was first to develop a mathematical model for conjugate heat transfer (natural convection) in a staggered through field electrode RF system and to use this model for natural convection effects in industrial scale processes. For this purpose, the developed comprehensive mathematical model was experimentally validated using the data from frozen tuna samples. The air temperature variation was also used for validation. Then, the developed model was used in industrial scale process simulations with the presence of natural convection. The industrially preferred flat plate systems were used in this part to determine the temperature and electric field evolutions. The results demonstrated the significant effect of the natural convection on sample surface temperature distribution and temperature change of air within the cavity. The evolved natural convection resulted in the variation of the heat transfer coefficient along the sample surfaces with significant changes in temperature. Based on these results, it might be concluded that the effect of air temperature change within the cavity during an RF processes should also be controlled and considered for industrial system design and process optimization