280 research outputs found
Giant Quantum Reflection of Neon Atoms from a Ridged Silicon Surface
The specular reflectivity of slow, metastable neon atoms from a silicon
surface was found to increase markedly when the flat surface was replaced by a
grating structure with parallel narrow ridges. For a surface with ridges that
have a sufficiently narrow top, the reflectivity was found to increase more
than two orders of magnitude at the incident angle of 10 mRad from the surface.
The slope of the reflectivity vs the incident angle near zero was found to be
nearly an order of magnitude smaller than that of a flat surface. A grating
with 6.5% efficiency for the first-order diffraction was fabricated by using
the ridged surface structure.Comment: 5 pages, 4 figures. To be published in J. Phys. Soc. Jp
Reconstruction of irradiated bone segmental defects with a biomaterial associating MBCP+Âź, microstructured collagen membrane and total bone marrow grafting: An experimental study in rabbits
The bone tissue engineering models used today are still a long way from any oncologic application as immediate postimplantation irradiation would decrease their osteoinductive potential. The aim of this study was to reconstruct a segmental critical size defect in a weight-bearing bone irradiated after implantation. Six white New Zealand rabbits were immediately implanted with a biomaterial associating resorbable collagen membrane EZÂź filled and micro-macroporous biphasic calcium phosphate granules (MBCP+Âź). After a daily schedule of radiation delivery, and within 4 weeks, a total autologous bone marrow (BM) graft was injected percutaneously into the center of the implant. All the animals were sacrificed at 16 weeks. Successful osseous colonization was found to have bridged the entire length of the defects. Identical distribution of bone ingrowth and residual ceramics at the different levels of the implant suggests that the BM graft plays an osteoinductive role in the center of the defect. Periosteum-like formation was observed at the periphery, with the collagen membrane most likely playing a role. This model succeeded in bridging a large segmental defect in weight-bearing bone with immediate postimplantation fractionated radiation delivery. This has significant implications for the bone tissue engineering approach to patients with cancer-related bone defects
Modeling and Optimization of Lactic Acid Synthesis by the Alkaline Degradation of Fructose in a Batch Reactor
The present work deals with the determination of the optimal operating conditions of lactic acid synthesis by the alkaline degradation of fructose. It is a complex transformation for which detailed knowledge is not available. It is carried out in a batch
or semi-batch reactor. The ââTendency Modelingââ approach, which consists of the development of an approximate stoichiometric and kinetic model, has been used.
An experimental planning method has been utilized as the database for model development.
The application of the experimental planning methodology allows comparison between the experimental and model response. The model is then used in an optimization procedure to compute the optimal process. The optimal control problem is converted into a nonlinear programming problem solved using the sequencial quadratic programming procedure coupled with the golden search method. The strategy developed allows simultaneously optimizing the different variables, which may be constrained. The validity of the methodology is illustrated by the determination
of the optimal operating conditions of lactic acid production
Imaging Gold Nanoparticles in Living Cells Environments using Heterodyne Digital Holographic Microscopy
This paper describes an imaging microscopic technique based on heterodyne
digital holography where subwavelength-sized gold colloids can be imaged in
cell environment. Surface cellular receptors of 3T3 mouse fibroblasts are
labeled with 40 nm gold nanoparticles, and the biological specimen is imaged in
a total internal reflection configuration with holographic microscopy. Due to a
higher scattering efficiency of the gold nanoparticles versus that of cellular
structures, accurate localization of a gold marker is obtained within a 3D
mapping of the entire sample's scattered field, with a lateral precision of 5
nm and 100 nm in the x,y and in the z directions respectively, demonstrating
the ability of holographic microscopy to locate nanoparticles in living cells
environments
Mandibular Segmental Defect Regenerated With Macroporous Biphasic Calcium Phosphate, Collagen Membrane, and Bone Marrow Graft in Dogs
OBJECTIVE:
To reconstruct segmental mandibulectomy using calcium phosphate ceramics and collagen membrane with a delayed bone marrow grafting in experimental animals.
DESIGN:
Defects of segmental mandibulectomy were filled with calcium phosphate granules and wrapped with a collagen membrane in 4 dogs and left empty as a control in 2 dogs. Two months later, a bone marrow graft was injected into the center of the implants. Animals were humanely killed after a 16-week delay.
SUBJECTS:
Six adult beagles were included in this study.
INTERVENTION:
Segmental mandibulectomy.
MAIN OUTCOME MEASURE:
Bone ingrowth and material resorption in the reconstructed segment.
RESULTS:
Successful osseous colonization bridged the whole length of the defects. The good new bone formation at the center and the periosteum-like formation at the periphery suggest the osteoinductive role of the bone marrow graft and the healing scaffold role of the membrane.
CONCLUSIONS:
This model succeeded in regenerating a large segmental defect in the mandible. An investigation with a postimplantation radiation delivery schedule is required with the use of this model, which should be considered as a preclinical study for a bone tissue engineering approach in patients with cancer-related bone defects
Photothermal Heterodyne Imaging of Individual Metallic Nanoparticles: Theory versus Experiments
We present the theoretical and detailed experimental characterizations of
Photothermal Heterodyne Imaging. An analytical expression of the photothermal
heterodyne signal is derived using the theory of light scattering from a
fluctuating medium. The amplitudes of the signals detected in the backward and
forward configurations are compared and their frequency dependences are
studied. The application of the Photothermal Heterodyne detection technique to
the absorption spectroscopy of individual gold nanoparticles is discussed and
the detection of small individual silver nanoparticles is demonstrated
A {\mu}-TPC detector for the characterization of low energy neutron fields
The AMANDE facility produces monoenergetic neutron fields from 2 keV to 20
MeV for metrological purposes. To be considered as a reference facility,
fluence and energy distributions of neutron fields have to be determined by
primary measurement standards. For this purpose, a micro Time Projection
Chamber is being developed to be dedicated to measure neutron fields with
energy ranging from 8 keV up to 1 MeV. In this work we present simulations
showing that such a detector, which allows the measurement of the ionization
energy and the 3D reconstruction of the recoil nucleus, provides the
determination of neutron energy and fluence of these neutron fields
Carbon nanotubes adhesion and nanomechanical behavior from peeling force spectroscopy
Applications based on Single Walled Carbon Nanotube (SWNT) are good example
of the great need to continuously develop metrology methods in the field of
nanotechnology. Contact and interface properties are key parameters that
determine the efficiency of SWNT functionalized nanomaterials and nanodevices.
In this work we have taken advantage of a good control of the SWNT growth
processes at an atomic force microscope (AFM) tip apex and the use of a low
noise (1E-13 m/rtHz) AFM to investigate the mechanical behavior of a SWNT
touching a surface. By simultaneously recording static and dynamic properties
of SWNT, we show that the contact corresponds to a peeling geometry, and
extract quantities such as adhesion energy per unit length, curvature and
bending rigidity of the nanotube. A complete picture of the local shape of the
SWNT and its mechanical behavior is provided
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