410 research outputs found
Impact of oxygen on gallium doped germanium
Germanium (Ge) has advantageous materials properties and is considered as a mainstream material for nanoelectronic applications. Understanding dopant–defect interactions is important to form well-defined doped regions for devices. Gallium (Ga) is a key p-type dopant in Ge. In the present density functional theory study, we concentrate on the structures and electronic structures of Ga doped Ge in the presence of Ge vacancies and oxygen. We provide information on the defect structures and charge transfer between the doped Ga atom and the nearest neighbor Ge atom. The calculations show that the presence of Ga on the Ge site facilitates the formation of nearest neighbor Ge vacancies at 0.75 eV. The formation of interstitial oxygen is endoergic with the formation of −2 charge in both bulk Ge and Ga substituted Ge although the substitution of Ga has slightly less impact on the oxygen interstitial formation
Hepatic zonation of carbon and nitrogen fluxes derived from glutamine and ammonia transformations
<p>Abstract</p> <p>Background</p> <p>Glutaminase predominates in periportal hepatocytes and it has been proposed that it determines the glutamine-derived nitrogen flow through the urea cycle. Glutamine-derived urea production should, thus, be considerably faster in periportal hepatocytes. This postulate, based on indirect observations, has not yet been unequivocally demonstrated, making a direct investigation of ureogenesis from glutamine highly desirable.</p> <p>Methods</p> <p>Zonation of glutamine metabolism was investigated in the bivascularly perfused rat liver with [U-<sup>14</sup>C]glutamine infusion (0.6 mM) into the portal vein (antegrade perfusion) or into the hepatic vein (retrograde perfusion).</p> <p>Results</p> <p>Ammonia infusion into the hepatic artery in retrograde and antegrade perfusion allowed to promote glutamine metabolism in the periportal region and in the whole liver parenchyma, respectively. The results revealed that the space-normalized glutamine uptake, indicated by <sup>14</sup>CO<sub>2 </sub>production, gluconeogenesis, lactate production and the associated oxygen uptake, predominates in the periportal region. Periportal predominance was especially pronounced for gluconeogenesis. Ureogenesis, however, tended to be uniformly distributed over the whole liver parenchyma at low ammonia concentrations (up to 1.0 mM); periportal predominance was found only at ammonia concentrations above 1 mM. The proportions between the carbon and nitrogen fluxes in periportal cells are not the same along the liver acinus.</p> <p>Conclusions</p> <p>In conclusion, the results of the present work indicate that the glutaminase activity in periportal hepatocytes is not the rate-controlling step of the glutamine-derived nitrogen flow through the urea cycle. The findings corroborate recent work indicating that ureogenesis is also an important ammonia-detoxifying mechanism in cells situated downstream to the periportal region.</p
An overview of structural aspects and health beneficial effects of antioxidant oligosaccharides
Background: Non-digestible oligosaccharides are versatile sources of chemical diversity, well known
for their prebiotic actions, found naturally in plants or produced by chemical or enzymatic synthesis or by hydrolysis
of polysaccharides. Compared to polyphenols or even polysaccharides, the antioxidant potential of oligosaccharides
is still unexplored. The aim of the present work was to provide an up-to-date, broad and critical contribution
on the topic of antioxidant oligosaccharides.
Methods: The search was performed by crossing the words oligosaccharides and antioxidant. Whenever possible,
attempts at establishing correlations between chemical structure and antioxidant activity were undertaken.
Results: The most representative in vitro and in vivo studies were compiled in two tables. Chitooligosaccharides
and xylooligosaccharides and their derivatives were the most studied up to now. The antioxidant activities of
oligosaccharides depend on the degree of polymerization and the method used for depolymerization. Other factors
influencing the antioxidant strength are solubility, monosaccharide composition, the type of glycosidic linkages
of the side chains, molecular weight, reducing sugar content, the presence of phenolic groups such as ferulic
acid, and the presence of uronic acid, among others. Modification of the antioxidant capacity of oligosaccharides
has been achieved by adding diverse organic groups to their structures, thus increasing also the spectrum of potentially
useful molecules.
Conclusion: A great amount of high-quality evidence has been accumulating during the last decade in support of
a meaningful antioxidant activity of oligosaccharides and derivatives. Ingestion of antioxidant oligosaccharides
can be visualized as beneficial to human and animal health.This work was funded by the Conselho Nacional de Desenvolvimento Cientffico e Tecnológico (CNPq), Brazil; grants numbers
40898/2016-5 and 307944/2015-8).info:eu-repo/semantics/publishedVersio
Diffusion and defect reactions between donors, C, and vacancies in Ge. II. Atomistic calculations of related complexes
Electronic structure calculations are used to study the stability, concentration, and migration of vacancy-donor (phosphorus, arsenic, and antimony) complexes in germanium, in the presence of carbon. The association of carbon with mobile vacancy-donor pairs can lead to energetically favorable and relatively immobile complexes. It is predicted that the complexes formed between lattice vacancies, carbon, and antimony substitutional atoms are more stable and less mobile compared to complexes composed of vacancies, carbon, and phosphorus or arsenic atoms. Then, with the use of mass action analysis, the relative concentrations of the most important complexes are calculated, which depend also on their relative stability not just their absolute stability. Overall, the theoretical predictions are consistent with experimental results, which determined that the diffusion of vacancy-donor defects is retarded in the presence of carbon, especially in samples with a high concentration of carbon. In addition, the calculations provide information on the structure and the equilibrium concentration of the most important complexes and details of their association energies
Fluorine effect on As diffusion in Ge
The enhanced diffusion of donor atoms, via a vacancy (V)-mechanism, severely affects the realization of ultrahigh doped regions in miniaturized germanium (Ge) based devices. In this work, we report a study about the effect of fluorine (F) on the diffusion of arsenic (As) in Ge and give insights on the physical mechanisms involved. With these aims we employed experiments in Ge co-implanted with F and As and density functional theory calculations. We demonstrate that the implantation of F enriches the Ge matrix in V, causing an enhanced diffusion of As within the layer amorphized by F and As implantation and subsequently regrown by solid phase epitaxy. Next to the end-of-range damaged region F forms complexes with Ge interstitials, that act as sinks for V and induce an abrupt suppression of As diffusion. The interaction of Ge interstitials with fluorine interstitials is confirmed by theoretical calculations. Finally, we prove that a possible F-As chemical interaction does not play any significant role on dopant diffusion. These results can be applied to realize abrupt ultra-shallow n-type doped regions in future generation of Ge-based devices
Time-dependent effects of intravenous H2S during long-term, resuscitated porcine hemorrhagic shock
Image Thresholding Technique Based On Fuzzy Partition And Entropy Maximization
Thresholding is a commonly used technique in image segmentation because of its fast and easy application. For this reason threshold selection is an important issue. There are two general approaches to threshold selection. One approach is based on the histogram of the image while the other is based on the gray scale information located in the local small areas. The histogram of an image contains some statistical data of the grayscale or color ingredients. In this thesis, an adaptive logical thresholding method is proposed for the binarization of blueprint images first. The new method exploits the geometric features of blueprint images. This is implemented by utilizing a robust windows operation, which is based on the assumption that the objects have "e;C"e; shape in a small area. We make use of multiple window sizes in the windows operation. This not only reduces computation time but also separates effectively thin lines from wide lines. Our method can automatically determine the threshold of images. Experiments show that our method is effective for blueprint images and achieves good results over a wide range of images. Second, the fuzzy set theory, along with probability partition and maximum entropy theory, is explored to compute the threshold based on the histogram of the image. Fuzzy set theory has been widely used in many fields where the ambiguous phenomena exist since it was proposed by Zadeh in 1965. And many thresholding methods have also been developed by using this theory. The concept we are using here is called fuzzy partition. Fuzzy partition means that a histogram is parted into several groups by some fuzzy sets which represent the fuzzy membership of each group because our method is based on histogram of the image . Probability partition is associated with fuzzy partition. The probability distribution of each group is derived from the fuzzy partition. Entropy which originates from thermodynamic theory is introduced into communications theory as a commonly used criteria to measure the information transmitted through a channel. It is adopted by image processing as a measurement of the information contained in the processed images. Thus it is applied in our method as a criterion for selecting the optimal fuzzy sets which partition the histogram. To find the threshold, the histogram of the image is partitioned by fuzzy sets which satisfy a certain entropy restriction. The search for the best possible fuzzy sets becomes an important issue. There is no efficient method for the searching procedure. Therefore, expansion to multiple level thresholding with fuzzy partition becomes extremely time consuming or even impossible. In this thesis, the relationship between a probability partition (PP) and a fuzzy C-partition (FP) is studied. This relationship and the entropy approach are used to derive a thresholding technique to select the optimal fuzzy C-partition. The measure of the selection quality is the entropy function defined by the PP and FP. A necessary condition of the entropy function arriving at a maximum is derived. Based on this condition, an efficient search procedure for two-level thresholding is derived, which makes the search so efficient that extension to multilevel thresholding becomes possible. A novel fuzzy membership function is proposed in three-level thresholding which produces a better result because a new relationship among the fuzzy membership functions is presented. This new relationship gives more flexibility in the search for the optimal fuzzy sets, although it also increases the complication in the search for the fuzzy sets in multi-level thresholding. This complication is solved by a new method called the "e;Onion-Peeling"e; method. Because the relationship between the fuzzy membership functions is so complicated it is impossible to obtain the membership functions all at once. The search procedure is decomposed into several layers of three-level partitions except for the last layer which may be a two-level one. So the big problem is simplified to three-level partitions such that we can obtain the two outmost membership functions without worrying too much about the complicated intersections among the membership functions. The method is further revised for images with a dominant area of background or an object which affects the appearance of the histogram of the image. The histogram is the basis of our method as well as of many other methods. A "e;bad"e; shape of the histogram will result in a bad thresholded image. A quadtree scheme is adopted to decompose the image into homogeneous areas and heterogeneous areas. And a multi-resolution thresholding method based on quadtree and fuzzy partition is then devised to deal with these images. Extension of fuzzy partition methods to color images is also examined. An adaptive thresholding method for color images based on fuzzy partition is proposed which can determine the number of thresholding levels automatically. This thesis concludes that the "e;C"e; shape assumption and varying sizes of windows for windows operation contribute to a better segmentation of the blueprint images. The efficient search procedure for the optimal fuzzy sets in the fuzzy-2 partition of the histogram of the image accelerates the process so much that it enables the extension of it to multilevel thresholding. In three-level fuzzy partition the new relationship presentation among the three fuzzy membership functions makes more sense than the conventional assumption and, as a result, performs better. A novel method, the "e;Onion-Peeling"e; method, is devised for dealing with the complexity at the intersection among the multiple membership functions in the multilevel fuzzy partition. It decomposes the multilevel partition into the fuzzy-3 partitions and the fuzzy-2 partitions by transposing the partition space in the histogram. Thus it is efficient in multilevel thresholding. A multi-resolution method which applies the quadtree scheme to distinguish the heterogeneous areas from the homogeneous areas is designed for the images with large homogeneous areas which usually distorts the histogram of the image. The new histogram based on only the heterogeneous area is adopted for partition and outperforms the old one. While validity checks filter out the fragmented points which are only a small portion of the whole image. Thus it gives good thresholded images for human face images
Biological activities and chemical constituents of Araucaria angustifolia: An effort to recover a species threatened by extinction
Background: Araucaria angustifolia (Bert.) O. Kuntze (A. brasiliensis), known as Paraná pine, is the sole native gymnosperm of the Atlantic forest in Brazil and has great economic, cultural and social importance. Its seed, known as pinhão, has been consumed since prehistoric times. Besides the nutritional aspects, different parts of A. angustifolia are also used in the Brazilian folk medicine for the treatment of rheumatism, respiratory infections, fatigue, anemia, among other disorders. Timber exploration has dramatically reduced the species population, and currently, A. angustifolia is classified as vulnerable regarding the risk of extinction.
Scope and Approach: This review presents the most recently uncovered details about the chemical composition of the various parts of the plant. Emphasis is given to the main isolated and identified compounds or fractions and their corresponding bioactivities.
Key Findings and Conclusions:.Apart from the nutritional properties of the pinhão, particularly as a starch source, this review reveals that a number of biological activities have been found in different parts of A. angustifolia (leaves, bark and pinhão coat), such as protection against DNA UV-induced damage, antioxidant, antiinflammatory, antiviral and digestive enzyme inhibiting activities. Further investigations should include parts of A. angustifolia that are currently discarded, such as the bark, bracts and the pinhão coat, with potential for use in pharmaceutical and cosmetic industries. Studies on A. angustifolia must combine two important elements: the need for preservation of a typical ecosystem and the implementation of the A. angustifolia forests as a true economic alternative for local residents.The authors thank the Fundação Araucária for funding this study. R.F. Oliveira, R.C.G. Correa, L. Bertonha and V.G. Correa thank Coordenação de Aperfeiçoamento do Pessoal do Ensino Superior (CAPES) for the financial support provided for their post-graduate studies in Universidade Estadual de Maringá. R.M. Peralta and A. Bracht are research grant recipients of Conselho Nacional de Desenvolvimento CientÃfico e Tecnologia (CNPq)
Multimodal brain imaging reveals structural differences in Alzheimer's disease polygenic risk carriers: A study in healthy young adults
Background Recent genome-wide association studies have identified genetic loci that jointly make a considerable contribution to risk of developing Alzheimer’s disease (AD). Because neuropathological features of AD can be present several decades before disease onset, we investigated whether effects of polygenic risk are detectable by neuroimaging in young adults. We hypothesized that higher polygenic risk scores (PRSs) for AD would be associated with reduced volume of the hippocampus and other limbic and paralimbic areas. We further hypothesized that AD PRSs would affect the microstructure of fiber tracts connecting the hippocampus with other brain areas. Methods We analyzed the association between AD PRSs and brain imaging parameters using T1-weighted structural (n = 272) and diffusion-weighted scans (n = 197). Results We found a significant association between AD PRSs and left hippocampal volume, with higher risk associated with lower left hippocampal volume (p = .001). This effect remained when the APOE gene was excluded (p = .031), suggesting that the relationship between hippocampal volume and AD is the result of multiple genetic factors and not exclusively variability in the APOE gene. The diffusion tensor imaging analysis revealed that fractional anisotropy of the right cingulum was inversely correlated with AD PRSs (p = .009). We thus show that polygenic effects of AD risk variants on brain structure can already be detected in young adults. Conclusions This finding paves the way for further investigation of the effects of AD risk variants and may become useful for efforts to combine genotypic and phenotypic data for risk prediction and to enrich future prevention trials of AD
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