A vision of re-distributed manufacturing for the UK’s consumer goods industry

The linear production of consumer goods is characterised by mass manufacture, multinational enterprises and globally dispersed supply chains. Redistributed manufacture (RDM) is an emerging topic, which seeks to enable a transition of the current linear model of production and consumption, by taking advantage of new technologies. This paper aims to explore the challenges, opportunities and further research questions to set a vision of Redistributed manufacturing for the UK’s consumer goods industry. To set this vision, a literature survey was conducted followed by a qualitative enquiry where PESTLE1 aspects of RDM were analysed. This analysis was interpreted through a roadmap. As a result of this roadmap, four RDM characteristics (i.e. customisation, use of digital technologies, local production and the development of new business models) were identified. These characteristics helped to set the future vision of RDM in the UK’s consumer goods sector

The Groundwater Drought Initiative (GDI): analysing and understanding groundwater drought across Europe

In Europe, it is estimated that around 65 % of drinking water is extracted from groundwater. Worryingly, groundwater drought events (defined as below normal groundwater levels) pose a threat to water security. Groundwater droughts are caused by seasonal to multi-seasonal or even multi-annual episodes of meteorological drought during which the drought propagates through the river catchment into the groundwater system by mechanisms of pooling, lagging, and lengthening of the drought signals. Recent European drought events in 2010–2012, 2015 and 2017–2018 exhibited spatial coherence across large areas, thus demonstrating the need for transboundary monitoring and analysis of groundwater level fluctuations. However, such monitoring and analysis of groundwater drought at a pan-European scale is currently lacking, and so represents a gap in drought research as well as in water management capability. To address this gap, the European Groundwater Drought Initiative (GDI), a pan-European collaboration, is undertaking a large-scale data synthesis of European groundwater level data. This is being facilitated by the establishment of a new network to co-ordinate groundwater drought research across Europe. This research will deliver the first assessment of spatio-temporal changes in groundwater drought status from ∼1960 to present, and a series of case studies on groundwater drought impacts in selected temperate and semi-arid environments across Europe. Here, we describe the methods used to undertake the continental-scale status assessment, which are more widely applicable to transboundary or large-scale groundwater level analyses also in regions beyond Europe, thereby enhancing groundwater management decisions and securing water supply

Bayesian models of eye movement selection with retinotopic maps

Abstract Among the various possible criteria guiding eye movement selection, we investigate the role of position uncertainty in the peripheral visual field. In particular, we suggest that, in everyday life situations of object tracking, eye movement selection probably includes a principle of reduction of uncertainty. To evaluate this hypothesis, we confront the movement predictions of computational models with human results from a psychophysical task. This task is a freely moving eye version of the Multiple Object Tracking task, where the eye movements may be used to compensate for low peripheral resolution. We design several Bayesian models of eye movement selection with increasing complexity, whose layered structures are inspired by the neurobiology of the brain areas implied this process. Finally, we compare the relative performances of these models with regard to the prediction of the recorded human movements, and show th

Solving the Sports League Scheduling Problem with Tabu Search

In this paper we present a tabu approach for a version of the Sports League Scheduling Problem. The approach adopted is based on a formulation of the problem as a Constraint Satisfaction Problem (CSP). Tests were carried out on problem instances of up to 40 teams representing 780 integer variables with 780 values per variable. Experimental results show that this approach outperforms some existing methods and is one of the most promising methods for solving problems of this type

Bayesian Action–Perception Computational Model: Interaction of Production and Recognition of Cursive Letters

In this paper, we study the collaboration of perception and action representations involved in cursive letter recognition and production. We propose a mathematical formulation for the whole perception–action loop, based on probabilistic modeling and Bayesian inference, which we call the Bayesian Action–Perception (BAP) model. Being a model of both perception and action processes, the purpose of this model is to study the interaction of these processes. More precisely, the model includes a feedback loop from motor production, which implements an internal simulation of movement. Motor knowledge can therefore be involved during perception tasks. In this paper, we formally define the BAP model and show how it solves the following six varied cognitive tasks using Bayesian inference: i) letter recognition (purely sensory), ii) writer recognition, iii) letter production (with different effectors), iv) copying of trajectories, v) copying of letters, and vi) letter recognition (with internal simulation of movements). We present computer simulations of each of these cognitive tasks, and discuss experimental predictions and theoretical developments

LUNEX5: A French FEL Test Facility Light Source Proposal

http://accelconf.web.cern.ch/AccelConf/IPAC2012/papers/tuppp005.pdfInternational audienceLUNEX5 is a new Free Electron Laser (FEL) source project aimed at delivering short and coherent X-ray pulses to probe ultrafast phenomena at the femto-second scale, to investigate extremely low density samples as well as to image individual nm scale objects

Discriminating instance generation for automated constraint model selection

One approach to automated constraint modelling is to generate, and then select from, a set of candidate models. This method is used by the automated modelling system Conjure. To select a preferred model or set of models for a problem class from the candidates Conjure produces, we use a set of training instances drawn from the target class. It is important that the training instances are discriminating. If all models solve a given instance in a trivial amount of time, or if no models solve it in the time available, then the instance is not useful for model selection. This paper addresses the task of generating small sets of discriminating training instances automatically. The instance space is determined by the parameters of the associated problem class. We develop a number of methods of finding parameter configurations that give discriminating training instances, some of them leveraging existing parameter-tuning techniques. Our experimental results confirm the success of our approach in reducing a large set of input models to a small set that we can expect to perform well for the given problem class

Simple conceptual graphs revisited: hypergraphs and conjunctive types for efficient projection algorithms

baget2003aInternational audienceSimple Conceptual Graphs (SGs) form the cornerstone for the "Conceptual Graphs" family of languages. In this model, the subsumptio operation is called projection; it is a labelled graphs homomorphism (a NP-hard problem). Designing efficient algorithms to compute projections between two SGs is thus of uttermost importance for the community building languages on top of this basic model. This paper presents some such algorithms, inspired by those developped for Constraint Satisfaction Problems. In order to benefit from the optimization work done in this community, we have chosen to present an alternate version of SGs, differences being the definition of these graphs as hypergraphs and the use of conjunctive types

Bead arrays for antibody and complement profiling reveal joint contribution of antibody isotypes to C3 deposition

The development of antigen arrays has provided researchers with great tools to identify reactivities against self or foreign antigens from body fluids. Yet, these approaches mostly do not address antibody isotypes and their effector functions even though these are key points for a more detailed understanding of disease processes. Here, we present a bead array-based assay for a multiplexed determination of antigen-specific antibody levels in parallel with their properties for complement activation. We measured the deposition of C3 fragments from serum samples to reflect the degree of complement activation via all three complement activation pathways. We utilized the assay on a bead array containing native and citrullinated peptide antigens to investigate the levels of IgG, IgM and IgA autoantibodies along with their complement activating properties in serum samples of 41 rheumatoid arthritis patients and 40 controls. Our analysis revealed significantly higher IgG reactivity against the citrullinated fibrinogen β and filaggrin peptides as well as an IgA reactivity that was exclusive for citrullinated fibrinogen β peptide and C3 deposition in rheumatoid arthritis patients. In addition, we characterized the humoral immune response against the viral EBNA-1 antigen to demonstrate the applicability of this assay beyond autoimmune conditions. We observed that particular buffer compositions were demanded for separate measurement of antibody reactivity and complement activation, as detection of antigen-antibody complexes appeared to be masked due to C3 deposition. We also found that rheumatoid factors of IgM isotype altered C3 deposition and introduced false-positive reactivities against EBNA-1 antigen. In conclusion, the presented bead-based assay setup can be utilized to profile antibody reactivities and immune-complex induced complement activation in a high-throughput manner and could facilitate the understanding and diagnosis of several diseases where complement activation plays role in the pathomechanism

Physician supply forecast: better than peering in a crystal ball?

<p>Abstract</p> <p>Background</p> <p>Anticipating physician supply to tackle future health challenges is a crucial but complex task for policy planners. A number of forecasting tools are available, but the methods, advantages and shortcomings of such tools are not straightforward and not always well appraised. Therefore this paper had two objectives: to present a typology of existing forecasting approaches and to analyse the methodology-related issues.</p> <p>Methods</p> <p>A literature review was carried out in electronic databases Medline-Ovid, Embase and ERIC. Concrete examples of planning experiences in various countries were analysed.</p> <p>Results</p> <p>Four main forecasting approaches were identified. The supply projection approach defines the necessary inflow to maintain or to reach in the future an arbitrary predefined level of service offer. The demand-based approach estimates the quantity of health care services used by the population in the future to project physician requirements. The needs-based approach involves defining and predicting health care deficits so that they can be addressed by an adequate workforce. Benchmarking health systems with similar populations and health profiles is the last approach. These different methods can be combined to perform a gap analysis. The methodological challenges of such projections are numerous: most often static models are used and their uncertainty is not assessed; valid and comprehensive data to feed into the models are often lacking; and a rapidly evolving environment affects the likelihood of projection scenarios. As a result, the internal and external validity of the projections included in our review appeared limited.</p> <p>Conclusion</p> <p>There is no single accepted approach to forecasting physician requirements. The value of projections lies in their utility in identifying the current and emerging trends to which policy-makers need to respond. A genuine gap analysis, an effective monitoring of key parameters and comprehensive workforce planning are key elements to improving the usefulness of physician supply projections.</p