The asymmetry of European integration: or why the EU cannot be a "Social Market Economy"

"Judge-made law has played a crucial role in the process of European integration. In the vertical dimension, it has greatly reduced the range of autonomous policy choices in the member states, and it has helped to expand the reach of European competences. At the same time, however, 'Integration through Law' does have a liberalizing and deregulatory impact on the socioeconomic regimes of EU member states. This effect is generally compatible with the status quo in liberal market economies, but it tends to undermine the institutions and policy legacies of Continental and Scandinavian social market economies. Given the high consensus requirements of European legislation, this structural asymmetry cannot be corrected through political action at the European level." (author's abstract

Systems Analysis Techniques for Business People: How Should These Techniques Differ from Techniques for IS Professionals

Much of the systems analysis and design literature and much of current practice seems to assume that the work will be organized and carried out by professional IS analysts. In the age of decentralization, flat organizations, and outsourcing, business professionals must take on more systems analysis responsibilities, either directly or through their subordinates and contractors

ANALISIS INVESTASI ALAT BERAT PROYEK JALAN PT. GADING MURNI PERKASA

Pekerjaan dalam bidang konstruksi membutuhkan Alat Berat untuk mempercepat pembangunan jalan, gedung, jembatan dan pekerjaan konstruksi lainnya. Kebutuhan alat berat guna mendukung pelaksanaan pembangunan di berbagai sektor waktu ke waktu semakin meningkat, oleh karena itu diperlukan alat berat untuk membantu memenuhi kebutuhan  tersebut. Alat berat yang di tinjau adalah Alat yang di gunakan dalam Proyek pekerjaan jalan Metode: Jenis penelitian ini adalah studi literatur yang menggunakan 5 metode kriteria investasi yaitu, Net Present Value (NPV), Internal Rate of Return (IRR), Break Even Point (BEP), Annual Equivalent (AE), dan Benevit Cost Ratio (BCR).Hasil: Perhitungan Net Present Value (NPV) menghasilkan keuntungan sebesar Rp.  575.153.388. Angka ini bernilai lebih dari 1 maka proyek ini layak untuk dijalankan. Perhitungan Internal Rate of Return (IRR) menghasilkan angka 10,37% dan angka ini lebih besar dari nilai MARR yaitu 9.8%, maka proyek ini memenuhi kriteria IRR dan layak untuk dijalankan. Perhitungan Break Even Point (BEP) menunjukkan Break Even terjadi pada tahun 2010 bulan 7 pada saat total pendapatan sebesar Rp. . .Perhitungan Annual Equivalent (AE) menghasilkan angka 51399604.44 angka ini lebih dari 1 maka investasi ini layak dijalankan. Perhitungan Benefit Cost Ratio (BCR) menghasilkan BCR sebesar , angka ini lebih dari 1 maka proyek investasi ini layak untuk dilaksanakan dan dapat memberikan keuntungan. Kata Kunci : Investasi, Alat Berat yang digunakan dalam Proyek jala

Clearing algorithms and network centrality

I show that the solution of a standard clearing model commonly used in contagion analyses for financial systems can be expressed as a specific form of a generalized Katz centrality measure under conditions that correspond to a system-wide shock. This result provides a formal explanation for earlier empirical results which showed that Katz-type centrality measures are closely related to contagiousness. It also allows assessing the assumptions that one is making when using such centrality measures as systemic risk indicators. I conclude that these assumptions should be considered too strong and that, from a theoretical perspective, clearing models should be given preference over centrality measures in systemic risk analyses

A Higher-Order Generalized Singular Value Decomposition for Comparison of Global mRNA Expression from Multiple Organisms

The number of high-dimensional datasets recording multiple aspects of a single phenomenon is increasing in many areas of science, accompanied by a need for mathematical frameworks that can compare multiple large-scale matrices with different row dimensions. The only such framework to date, the generalized singular value decomposition (GSVD), is limited to two matrices. We mathematically define a higher-order GSVD (HO GSVD) for N≥2 matrices , each with full column rank. Each matrix is exactly factored as Di = UiΣiVT, where V, identical in all factorizations, is obtained from the eigensystem SV = VΛ of the arithmetic mean S of all pairwise quotients of the matrices , i≠j. We prove that this decomposition extends to higher orders almost all of the mathematical properties of the GSVD. The matrix S is nondefective with V and Λ real. Its eigenvalues satisfy λk≥1. Equality holds if and only if the corresponding eigenvector vk is a right basis vector of equal significance in all matrices Di and Dj, that is σi,k/σj,k = 1 for all i and j, and the corresponding left basis vector ui,k is orthogonal to all other vectors in Ui for all i. The eigenvalues λk = 1, therefore, define the “common HO GSVD subspace.” We illustrate the HO GSVD with a comparison of genome-scale cell-cycle mRNA expression from S. pombe, S. cerevisiae and human. Unlike existing algorithms, a mapping among the genes of these disparate organisms is not required. We find that the approximately common HO GSVD subspace represents the cell-cycle mRNA expression oscillations, which are similar among the datasets. Simultaneous reconstruction in the common subspace, therefore, removes the experimental artifacts, which are dissimilar, from the datasets. In the simultaneous sequence-independent classification of the genes of the three organisms in this common subspace, genes of highly conserved sequences but significantly different cell-cycle peak times are correctly classified

Electromyographic and Joint Kinematic Patterns in Runner\u27s Dystonia.

Runner’s dystonia (RD) is a task-specific focal dystonia of the lower limbs that occurs when running. In this retrospective case series, we present surface electromyography (EMG) and joint kinematic data from thirteen patients with RD who underwent instrumented gait analysis (IGA) at the Functional and Biomechanics Laboratory at the National Institutes of Health. Four cases of RD are described in greater detail to demonstrate the potential utility of EMG with kinematic studies to identify dystonic muscle groups in RD. In these cases, the methodology for muscle selection for botulinum toxin therapy and the therapeutic response is discussed. Lateral heel whip, a proposed novel presentation of lower-limb dystonia, is also described

Renewable beta-elemene based cyclic carbonates for the preparation of oligo(hydroxyurethane)s

Conversion of β-elemene into new β-elemene dicarbonates through epoxidation and halide salt-catalyzed CO2 cycloaddition reactions is reported. Step-growth polyaddition of this dicarbonate to five different, commercial diamines was investigated under neat conditions at 150 °C yielding non-isocyanate-based low molecular weight oligo(hydroxyurethane)s with 1.3≤Mn≤6.3 kDa and 1.3≤Ð≤2.1, and with glass transition temperatures ranging from −59 to 84 °C. The preparation of one selected polyhydroxyurethane material, obtained in the presence of Jeffamine® D-2010 was scaled-up to 43 g. The latter, when combined in a formulation using Irgacure® 2100 and Laromer® LR 9000 allowed the preparation of coatings that were analyzed with several techniques showing the potential of these biobased oligourethanes towards the preparation of commercially relevant materials

Risk factors for acquisition of hepatitis C virus infection: a case series and potential implications for disease surveillance

BACKGROUND: Transmission of hepatitis C vims (HCV) is strongly associated with use of contaminated blood products and injection drugs. Other "non-parental" modes of transmission including sexual activity have been increasingly recognized. We examined risk factors for acquiring HCV in patients who were referred to two tertiary care centers and enrolled in an antiviral therapy protocol. METHODS: Interviews of 148 patients were conducted apart from their physician evaluation using a structured questionnaire covering demographics and risk factors for HCV acquisition. RESULTS: Risk factors (blood products, injection/intranasal drugs, razor blades/ toothbrushes, body/ear piercing, occupational exposure, sexual activity) were identified in 141 (95.3%) of participants; 23 (15.5%) had one (most frequently blood or drug exposure), 41 (27.7%) had two, and 84 (53.4%) had more than two risk factors. No patient reported sexual activity as a sole risk factor. Body piercing accounted for a high number of exposures in women. Men were more likely to have exposure to street drugs but less exposure to blood products than women. Blood product exposure was less common in younger than older HCV patients. CONCLUSION: One and often multiple risk factors could be identified in nearly all HCV-infected patients seen in a referral practice. None named sexual transmission as the sole risk factor. The development of a more complete profile of factors contributing to transmission of HCV infection may assist in clinical and preventive efforts. The recognition of the potential presence of multiple risk factors may have important implications in the approach to HCV surveillance, and particularly the use of hierarchical algorithms in the study of risk factors

Status quo: Levels of Campylobacter spp. and hygiene indicators in German slaughterhouses for broiler and turkey

Poultry is a common reservoir for Campylobacter and a main source for human campylobacteriosis. With broiler being the predominant poultry for food production, most food safety related research is conducted for this species, for turkey, few studies are available. Although animals are typically colonized at the farm level, the slaughtering process is considered an important factor in re- and cross-contamination. We examined the development of Campylobacter, E. coli and total colony counts (TCC) after several processing steps in three broiler and one turkey slaughterhouses. Whole carcass rinsing and neck skin sampling was applied for broilers resulting in 486 samples in total, while 126 neck skin samples were collected for turkeys. A decrease in the loads of the different bacterial groups along the broiler slaughtering process was observed. Campylobacter mean counts dropped from 4.5 ± 1.7 log10 CFU/ml after killing to 1.6 ± 0.4 log10 CFU/ml after chilling. However, an increase in Campylobacter counts was evident after evisceration before the values again decreased by the final processing step. Although the Campylobacter prevalence in the turkey samples showed a similar development, the bacterial loads were much lower with 1.7 ± 0.3 log10 CFU/g after killing and 1.7 ± 0.4 log10 CFU/g after chilling compared to those of broilers. The loads of E. coli and total colony count of turkey were higher after killing, were reduced by scalding and remained stable until after chilling. This study highlights trends during the slaughtering process in reducing the levels of Campylobacter, E. coli, and total colony counts for broiler and turkey carcasses, from the initial step to after chilling. These results contribute to our understanding of microbial dynamics during meat processing